Current Treatment Options in Neurology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Treatment of SUNCT/SUNA, Paroxysmal Hemicrania, and Hemicrania Continua: An Update Including Single-Arm Meta-analyses
AbstractPurpose of ReviewThis review presents a critical appraisal of the treatment strategies for short-lasting unilateral neuralgiform headache attacks (SUNHA), paroxysmal hemicrania (PH), and hemicrania continua (HC). We assess the available, though sparse, evidence on both medical and surgical treatments. In addition, we present estimated pooled analyses of the most common treatments and emphasize recent promising findings.Recent FindingsThe majority of literature available on the treatment of these rare trigeminal autonomic cephalalgias are small open-label observational studies and case reports. Pooled analyses revea...
Source: Current Treatment Options in Neurology - November 11, 2020 Category: Neurology Source Type: research

Pharmacotherapy for Small Fiber Neuropathy
AbstractPurpose of reviewSmall fiber neuropathy (SFN) is a condition that affects small nerve fibers leading to a variety of symptoms, including pain, discomfort, tingling, and sensory loss. The development of new drugs is commonly complicated by variable medication pharmacokinetics and patients ’ response to treatment due to comorbidities. In this review, we discuss currently used drugs, including the evidence about their efficacy. We also mention the medications with a questionable response in SFN treatment and those that are potential emerging therapies.Recent findingsSFN treatment is aimed towards addressing the caus...
Source: Current Treatment Options in Neurology - November 9, 2020 Category: Neurology Source Type: research

Vascular Events, Vascular Disease and Vascular Risk Factors —Strongly Intertwined with COVID-19
AbstractPurpose of reviewTo elucidate the intertwining of vascular events, vascular disease and vascular risk factors and COVID-19.Recent findingsStrokes are a leading cause of disability and death worldwide. Vascular risk factors are important drivers of strokes. There are unmodifiable vascular risk factors such as age and ethnicity and modifiable vascular risk factors. According to the INTERSTROKE study, the 10 most frequent modifiable vascular risk factors are arterial hypertension, physical inactivity, overweight, dyslipidaemia, smoking, unhealthy diet, cardiac pathologies, diabetes mellitus, stress/depression and over...
Source: Current Treatment Options in Neurology - October 8, 2020 Category: Neurology Source Type: research

COVID-19 Era Stroke Service: Virtually Normal
ConclusionsZoom conferences are a promising technology for stroke services. Further studies are needed to further elucidate their benefits and drawbacks. (Source: Current Treatment Options in Neurology)
Source: Current Treatment Options in Neurology - October 8, 2020 Category: Neurology Source Type: research

Secondary Causes of Myositis
AbstractPurpose of reviewThe purpose of this paper is to comprehensively evaluate secondary causes of inflammatory myopathies (myositis) and to review treatment options.Recent findingsThis review highlights recent advancements in our understanding of known causes of myositis, including newer drugs that may cause myositis such as checkpoint inhibitors and viruses such as influenza, HIV, and SARS-CoV2. We also discuss treatment for malignancy-associated myositis and overlap myositis, thought to be a separate entity from other rheumatologic diseases.SummaryInfections, drugs, rheumatologic diseases, and malignancies are import...
Source: Current Treatment Options in Neurology - October 5, 2020 Category: Neurology Source Type: research

Unraveling the Possible Routes of SARS-COV-2 Invasion into the Central Nervous System
We present data regarding the family of Coronaviruses (CoVs) and the central nervous system (CNS), and describe parallels between SARS-CoV-2 and other members of the family, which have been investigated in more depth and combine these findings with the recent advancements regarding SARS-CoV-2.SummarySARS-CoV-2 like other CoVs is neuroinvasive, neurotropic and neurovirulent. Two main pathways of CNS penetration seem to be the strongest candidates, the hematogenous and the neuronal. Τhe olfactory route in particular appears to play a significant role in neuroinvasion of coronaviruses and SARS-CoV-2, as well. However, existi...
Source: Current Treatment Options in Neurology - September 24, 2020 Category: Neurology Source Type: research

A Literature Systematic Review with Meta-Analysis of Symptoms Prevalence in Covid-19: the Relevance of Olfactory Symptoms in Infection Not Requiring Hospitalization
AbstractPurpose of reviewTo investigate the association between the olfactory dysfunction and the more typical symptoms (fever, cough, dyspnoea) within the Sars-CoV-2 infection (COVID-19) in hospitalized and non-hospitalized patients.Recent findingsPubMed, Scopus and Web of Science databases were reviewed from May 5, 2020, to June 1, 2020. Inclusion criteria included English, French, German, Spanish or Italian language studies containing original data related to COVID19, anosmia, fever, cough, and dyspnoea, in both hospital and non-hospital settings. Two investigators independently reviewed all manuscripts and performed qu...
Source: Current Treatment Options in Neurology - August 27, 2020 Category: Neurology Source Type: research

Treatment Updates in Postural Tachycardia Syndrome
AbstractPurpose of reviewPostural tachycardia syndrome is a common condition characterized by the presence of orthostatic intolerance in conjunction with excessive postural tachycardia. This review will focus on treatment updates in postural tachycardia syndrome and will include a discussion of rehabilitative, vasopressor, heart rate modulation, volume expansion, and immunomodulatory treatment strategies.Recent findingsA recent study added to existing literature the benefits of exercise retraining in postural tachycardia syndrome (POTS) patients who were able to successfully complete a 3-month exercise regimen. Another rec...
Source: Current Treatment Options in Neurology - August 24, 2020 Category: Neurology Source Type: research

Treatment Updates for Neuromuscular Channelopathies
This article aims to review the current and upcoming treatment options of primary muscle channelopathies including the non-dystrophic myotonias and periodic paralyses.Recent findingsThe efficacy of mexiletine in the treatment of myotonia is now supported by two randomised placebo-controlled trials, one of which utilised a novel aggregated n-of-1 design. This has resulted in licencing of the drug via orphan drug status. There is also good evidence that mexiletine is well tolerated and safe in this patient group without the need for intensive monitoring. A range of alternative antimyotonic treatment options include lamotrigi...
Source: Current Treatment Options in Neurology - August 21, 2020 Category: Neurology Source Type: research

Neurologic Manifestations of Systemic Disease: Seizure
AbstractPurpose of reviewThe goal of this paper is to review the pathophysiology and briefly discuss the management of acute symptomatic seizures secondary to various systemic conditions.Recent findingsSeizures are a common first neurological manifestation of systemic conditions and can assist in early recognition and diagnosis of these conditions. This paper reviews acute symptomatic seizures secondary to vascular disease, malignancy, underlying autoimmune etiologies, infection, toxic metabolic conditions, and nutritional causes.SummaryAcute symptomatic seizures and systemic conditions have a bidirectional relationship �...
Source: Current Treatment Options in Neurology - August 10, 2020 Category: Neurology Source Type: research

COVID-19 and Sleep in Medical Staff: Reflections, Clinical Evidences, and Perspectives
AbstractPurpose of the reviewThere is evidence that, before the coronavirus pandemic 2019 (COVID-19), healthcare workers did not experience good sleep quality with relevant consequences on health. By contrast, little is known about the sleep quality of medical staff during the COVID-19 pandemic. In this review, we aimed to contribute with a review of the literature, sharing our clinical experience supported by actigraphic evaluation and by proposing future strategies.Recent findingsSleep disorders, in particular insomnia, have been commonly reported in frontline medical workers, in hospitals during the COVID-19 pandemic an...
Source: Current Treatment Options in Neurology - August 5, 2020 Category: Neurology Source Type: research

Neurologic Manifestations of Systemic Disease: Sleep Disorders
AbstractPurpose of reviewSleep is intimately involved in overall health and wellbeing. We provide a comprehensive report on the interplay between systemic diseases and sleep to optimize the outcomes of systemic disorders.Recent findingsSpanning the categories of endocrinologic disorders, metabolic/toxic disturbances, renal, cardiovascular, pulmonary, gastrointestinal, infectious diseases, autoimmune disorders, malignancy, and critical illness, the review highlights the prevalent coexisting pathology of sleep across the spectrum of systemic disorders. Although it is rare that treating a sleep symptom can cure disease, atten...
Source: Current Treatment Options in Neurology - August 5, 2020 Category: Neurology Source Type: research

Management of Primary Lateral Sclerosis
AbstractPurpose of reviewPrimary lateral sclerosis is a progressive neurodegenerative process that primarily affects upper motor neuron and presents with progressive stiffness and spasticity in all muscle groups. Given its rarity, diagnosis can be difficult and there has been limited research into what the best treatment is. This review will work to summarize the current available knowledge on the management of primary lateral sclerosis (PLS) including medications, nonpharmacologic interventions, diet, and exercise.Recent findingsThere have been no controlled studies of therapies in PLS. Management decisions are based on e...
Source: Current Treatment Options in Neurology - August 5, 2020 Category: Neurology Source Type: research

Take Care
(Source: Current Treatment Options in Neurology)
Source: Current Treatment Options in Neurology - August 5, 2020 Category: Neurology Source Type: research

Secondary Cerebrovascular Prevention in Light of the COVID-19 Pandemic
Conclusion:We recommend:(1) As in normal times, during the COVID-19 pandemic wave, patients need to seek urgent medical attention in case of any acute cerebrovascular event. This will assure they receive needed rapid cerebrovascular secondary prevention in addition to acute intravenous and endovascular reperfusion strategies.(2) As in normal times, during the COVID-19 pandemic wave, it is of utmost importance that patients adhere to their individual recommendations for secondary prevention.(3) Optimal secondary but also primary cerebrovascular prevention might reduce the burden of COVID-19 now and during potential subseque...
Source: Current Treatment Options in Neurology - August 4, 2020 Category: Neurology Source Type: research