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The complex relationship of Wnt-signaling pathways and cilia
This article addresses these new insights and different links and relationships between cilia and Wnt signaling.PMID:38043953 | DOI:10.1016/bs.ctdb.2023.09.002 (Source: Current Topics in Developmental Biology)
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Linh T Vuong Marek Mlodzik Source Type: research

Crosstalk between the mTOR pathway and primary cilia in human diseases
Curr Top Dev Biol. 2023;155:1-37. doi: 10.1016/bs.ctdb.2023.09.004. Epub 2023 Nov 4.ABSTRACTAutophagy is a fundamental catabolic process whereby excessive or damaged cytoplasmic components are degraded through lysosomes to maintain cellular homeostasis. Studies of mTOR signaling have revealed that mTOR controls biomass generation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Primary cilia, the assembly of which depends on kinesin molecular motors, serve as sensory organelles and signaling platforms. Given these pathways' central role in maintaining cellular and physiologica...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Philipp P Prosseda Svenja Dannewitz Prosseda Matthew Tran Paloma B Liton Yang Sun Source Type: research

Patient stem cell-derived in vitro disease models for developing novel therapies of retinal ciliopathies
Curr Top Dev Biol. 2023;155:127-163. doi: 10.1016/bs.ctdb.2023.09.003. Epub 2023 Nov 4.ABSTRACTPrimary cilia are specialized organelles on the surface of almost all cells in vertebrate tissues and are primarily involved in the detection of extracellular stimuli. In retinal photoreceptors, cilia are uniquely modified to form outer segments containing components required for the detection of light in stacks of membrane discs. Not surprisingly, vision impairment is a frequent phenotype associated with ciliopathies, a heterogeneous class of conditions caused by mutations in proteins required for formation, maintenance and/or f...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kamil Kruczek Anand Swaroop Source Type: research

Control of protein and lipid composition of photoreceptor outer segments-Implications for retinal disease
Curr Top Dev Biol. 2023;155:165-225. doi: 10.1016/bs.ctdb.2023.09.001. Epub 2023 Oct 5.ABSTRACTVision is arguably our most important sense, and its loss brings substantial limitations to daily life for affected individuals. Light is perceived in retinal photoreceptors (PRs), which are highly specialized neurons subdivided into several compartments with distinct functions. The outer segments (OSs) of photoreceptors represent highly specialized primary ciliary compartments hosting the phototransduction cascade, which transforms incoming light into a neuronal signal. Retinal disease can result from various pathomechanisms ori...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Markus Masek Ruxandra Bachmann-Gagescu Source Type: research

Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research