Current Opinion in Structural Biology 
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Editorial overview: Restructuring drug design and development
Curr Opin Struct Biol. 2023 Nov 7;83:102727. doi: 10.1016/j.sbi.2023.102727. Online ahead of print.NO ABSTRACTPMID:37944397 | DOI:10.1016/j.sbi.2023.102727 (Source: Current Opinion in Structural Biology)
Source: Current Opinion in Structural Biology - November 9, 2023 Category: Biology Authors: Andrew R Leach Alison E Ondrus Source Type: research
B < sub > 12 < /sub > -dependent radical SAM enzymes: Ever expanding structural and mechanistic diversity
Curr Opin Struct Biol. 2023 Nov 4;83:102725. doi: 10.1016/j.sbi.2023.102725. Online ahead of print.ABSTRACTIn the last decade, B12-dependent radical SAM enzymes have emerged as central biocatalysts in the biosynthesis of a myriad of natural products. Notably, these enzymes have been shown to catalyze carbon-carbon bond formation on unactivated carbon atoms leading to unusual methylations. Recently, structural studies have revealed unprecedented insights into the complex chemistry catalyzed by these enzymes. In this review, we cover recent advances in our understanding of B12-dependent radical SAM enzymes from a mechanistic...
Source: Current Opinion in Structural Biology - November 6, 2023 Category: Biology Authors: Alhosna Benjdia Olivier Berteau Source Type: research
Topology regulatory elements: From shaping genome architecture to gene regulation
Curr Opin Struct Biol. 2023 Nov 4;83:102723. doi: 10.1016/j.sbi.2023.102723. Online ahead of print.ABSTRACTThe importance of 3D genome topology in the control of gene expression is becoming increasingly apparent, while regulatory mechanisms remain incompletely understood. Several recent studies have identified architectural elements that influence developmental gene expression by shaping locus topology. We refer to these elements as topological regulatory elements (TopoREs) to reflect their dual roles in genome organisation and gene expression. Importantly, these elements do not harbour autonomous transcriptional activatio...
Source: Current Opinion in Structural Biology - November 6, 2023 Category: Biology Authors: Liang-Fu Chen Hannah Katherine Long Source Type: research
B < sub > 12 < /sub > -dependent radical SAM enzymes: Ever expanding structural and mechanistic diversity
Curr Opin Struct Biol. 2023 Nov 4;83:102725. doi: 10.1016/j.sbi.2023.102725. Online ahead of print.ABSTRACTIn the last decade, B12-dependent radical SAM enzymes have emerged as central biocatalysts in the biosynthesis of a myriad of natural products. Notably, these enzymes have been shown to catalyze carbon-carbon bond formation on unactivated carbon atoms leading to unusual methylations. Recently, structural studies have revealed unprecedented insights into the complex chemistry catalyzed by these enzymes. In this review, we cover recent advances in our understanding of B12-dependent radical SAM enzymes from a mechanistic...
Source: Current Opinion in Structural Biology - November 6, 2023 Category: Biology Authors: Alhosna Benjdia Olivier Berteau Source Type: research
Topology regulatory elements: From shaping genome architecture to gene regulation
Curr Opin Struct Biol. 2023 Nov 4;83:102723. doi: 10.1016/j.sbi.2023.102723. Online ahead of print.ABSTRACTThe importance of 3D genome topology in the control of gene expression is becoming increasingly apparent, while regulatory mechanisms remain incompletely understood. Several recent studies have identified architectural elements that influence developmental gene expression by shaping locus topology. We refer to these elements as topological regulatory elements (TopoREs) to reflect their dual roles in genome organisation and gene expression. Importantly, these elements do not harbour autonomous transcriptional activatio...
Source: Current Opinion in Structural Biology - November 6, 2023 Category: Biology Authors: Liang-Fu Chen Hannah Katherine Long Source Type: research
B < sub > 12 < /sub > -dependent radical SAM enzymes: Ever expanding structural and mechanistic diversity
Curr Opin Struct Biol. 2023 Nov 4;83:102725. doi: 10.1016/j.sbi.2023.102725. Online ahead of print.ABSTRACTIn the last decade, B12-dependent radical SAM enzymes have emerged as central biocatalysts in the biosynthesis of a myriad of natural products. Notably, these enzymes have been shown to catalyze carbon-carbon bond formation on unactivated carbon atoms leading to unusual methylations. Recently, structural studies have revealed unprecedented insights into the complex chemistry catalyzed by these enzymes. In this review, we cover recent advances in our understanding of B12-dependent radical SAM enzymes from a mechanistic...
Source: Current Opinion in Structural Biology - November 6, 2023 Category: Biology Authors: Alhosna Benjdia Olivier Berteau Source Type: research
Topology regulatory elements: From shaping genome architecture to gene regulation
Curr Opin Struct Biol. 2023 Nov 4;83:102723. doi: 10.1016/j.sbi.2023.102723. Online ahead of print.ABSTRACTThe importance of 3D genome topology in the control of gene expression is becoming increasingly apparent, while regulatory mechanisms remain incompletely understood. Several recent studies have identified architectural elements that influence developmental gene expression by shaping locus topology. We refer to these elements as topological regulatory elements (TopoREs) to reflect their dual roles in genome organisation and gene expression. Importantly, these elements do not harbour autonomous transcriptional activatio...
Source: Current Opinion in Structural Biology - November 6, 2023 Category: Biology Authors: Liang-Fu Chen Hannah Katherine Long Source Type: research
B < sub > 12 < /sub > -dependent radical SAM enzymes: Ever expanding structural and mechanistic diversity
Curr Opin Struct Biol. 2023 Nov 4;83:102725. doi: 10.1016/j.sbi.2023.102725. Online ahead of print.ABSTRACTIn the last decade, B12-dependent radical SAM enzymes have emerged as central biocatalysts in the biosynthesis of a myriad of natural products. Notably, these enzymes have been shown to catalyze carbon-carbon bond formation on unactivated carbon atoms leading to unusual methylations. Recently, structural studies have revealed unprecedented insights into the complex chemistry catalyzed by these enzymes. In this review, we cover recent advances in our understanding of B12-dependent radical SAM enzymes from a mechanistic...
Source: Current Opinion in Structural Biology - November 6, 2023 Category: Biology Authors: Alhosna Benjdia Olivier Berteau Source Type: research
Topology regulatory elements: From shaping genome architecture to gene regulation
Curr Opin Struct Biol. 2023 Nov 4;83:102723. doi: 10.1016/j.sbi.2023.102723. Online ahead of print.ABSTRACTThe importance of 3D genome topology in the control of gene expression is becoming increasingly apparent, while regulatory mechanisms remain incompletely understood. Several recent studies have identified architectural elements that influence developmental gene expression by shaping locus topology. We refer to these elements as topological regulatory elements (TopoREs) to reflect their dual roles in genome organisation and gene expression. Importantly, these elements do not harbour autonomous transcriptional activatio...
Source: Current Opinion in Structural Biology - November 6, 2023 Category: Biology Authors: Liang-Fu Chen Hannah Katherine Long Source Type: research
Structure-function relationships in protein homorepeats
Curr Opin Struct Biol. 2023 Nov 2;83:102726. doi: 10.1016/j.sbi.2023.102726. Online ahead of print.ABSTRACTHomorepeats (or polyX), protein segments containing repetitions of the same amino acid, are abundant in proteomes from all kingdoms of life and are involved in crucial biological functions as well as several neurodegenerative and developmental diseases. Mainly inserted in disordered segments of proteins, the structure/function relationships of homorepeats remain largely unexplored. In this review, we summarize present knowledge for the most abundant homorepeats, highlighting the role of the inherent structure and the ...
Source: Current Opinion in Structural Biology - November 4, 2023 Category: Biology Authors: Carlos A Elena-Real Pablo Mier Nathalie Sibille Miguel A Andrade-Navarro Pau Bernad ó Source Type: research
Structure-function relationships in protein homorepeats
Curr Opin Struct Biol. 2023 Nov 2;83:102726. doi: 10.1016/j.sbi.2023.102726. Online ahead of print.ABSTRACTHomorepeats (or polyX), protein segments containing repetitions of the same amino acid, are abundant in proteomes from all kingdoms of life and are involved in crucial biological functions as well as several neurodegenerative and developmental diseases. Mainly inserted in disordered segments of proteins, the structure/function relationships of homorepeats remain largely unexplored. In this review, we summarize present knowledge for the most abundant homorepeats, highlighting the role of the inherent structure and the ...
Source: Current Opinion in Structural Biology - November 4, 2023 Category: Biology Authors: Carlos A Elena-Real Pablo Mier Nathalie Sibille Miguel A Andrade-Navarro Pau Bernad ó Source Type: research
All over or overall - Do we understand allostery?
Curr Opin Struct Biol. 2023 Oct 26;83:102724. doi: 10.1016/j.sbi.2023.102724. Online ahead of print.ABSTRACTAllostery is probably the most important concept in the regulation of cellular processes. Models to explain allostery are plenty. Each sheds light on different aspects but their entirety conveys an ambiguous feeling of comprehension and disappointment. Here, I discuss the most popular allostery models, their roots, similarities, and limitations. All of them are thermodynamic models. Naturally this bears a certain degree of redundancy, which forms the center of this review. After sixty years, many questions remain una...
Source: Current Opinion in Structural Biology - October 28, 2023 Category: Biology Authors: Hagen Hofmann Source Type: research
All over or overall - Do we understand allostery?
Curr Opin Struct Biol. 2023 Oct 26;83:102724. doi: 10.1016/j.sbi.2023.102724. Online ahead of print.ABSTRACTAllostery is probably the most important concept in the regulation of cellular processes. Models to explain allostery are plenty. Each sheds light on different aspects but their entirety conveys an ambiguous feeling of comprehension and disappointment. Here, I discuss the most popular allostery models, their roots, similarities, and limitations. All of them are thermodynamic models. Naturally this bears a certain degree of redundancy, which forms the center of this review. After sixty years, many questions remain una...
Source: Current Opinion in Structural Biology - October 28, 2023 Category: Biology Authors: Hagen Hofmann Source Type: research
All over or overall - Do we understand allostery?
Curr Opin Struct Biol. 2023 Oct 26;83:102724. doi: 10.1016/j.sbi.2023.102724. Online ahead of print.ABSTRACTAllostery is probably the most important concept in the regulation of cellular processes. Models to explain allostery are plenty. Each sheds light on different aspects but their entirety conveys an ambiguous feeling of comprehension and disappointment. Here, I discuss the most popular allostery models, their roots, similarities, and limitations. All of them are thermodynamic models. Naturally this bears a certain degree of redundancy, which forms the center of this review. After sixty years, many questions remain una...
Source: Current Opinion in Structural Biology - October 28, 2023 Category: Biology Authors: Hagen Hofmann Source Type: research
All over or overall - Do we understand allostery?
Curr Opin Struct Biol. 2023 Oct 26;83:102724. doi: 10.1016/j.sbi.2023.102724. Online ahead of print.ABSTRACTAllostery is probably the most important concept in the regulation of cellular processes. Models to explain allostery are plenty. Each sheds light on different aspects but their entirety conveys an ambiguous feeling of comprehension and disappointment. Here, I discuss the most popular allostery models, their roots, similarities, and limitations. All of them are thermodynamic models. Naturally this bears a certain degree of redundancy, which forms the center of this review. After sixty years, many questions remain una...
Source: Current Opinion in Structural Biology - October 28, 2023 Category: Biology Authors: Hagen Hofmann Source Type: research
