Controls, comparator arms, and designs for critical care comparative effectiveness research: It's complicated
CONCLUSION: Flawed critical care comparative effectiveness research trial designs can lead to unsound trial conclusions, compromise informed consent, and increase risks to research subjects, undermining the major goal of comparative effectiveness research: to inform current practice. Well-constructed control and comparator arms comprise indispensable elements of critical care comparative effectiveness research trials, key to improving the trials' safety and to generating trial results likely to improve patient outcomes in clinical practice.PMID:37615179 | DOI:10.1177/17407745231195094 (Source: Clinical Trials)
Source: Clinical Trials - August 24, 2023 Category: Research Authors: Verity J Ford Harvey G Klein Robert L Danner Willard N Applefeld Jeffrey Wang Irene Cortes-Puch Peter Q Eichacker Charles Natanson Source Type: research
Controls, comparator arms, and designs for critical care comparative effectiveness research: It's complicated
CONCLUSION: Flawed critical care comparative effectiveness research trial designs can lead to unsound trial conclusions, compromise informed consent, and increase risks to research subjects, undermining the major goal of comparative effectiveness research: to inform current practice. Well-constructed control and comparator arms comprise indispensable elements of critical care comparative effectiveness research trials, key to improving the trials' safety and to generating trial results likely to improve patient outcomes in clinical practice.PMID:37615179 | DOI:10.1177/17407745231195094 (Source: Clinical Trials)
Source: Clinical Trials - August 24, 2023 Category: Research Authors: Verity J Ford Harvey G Klein Robert L Danner Willard N Applefeld Jeffrey Wang Irene Cortes-Puch Peter Q Eichacker Charles Natanson Source Type: research
Controls, comparator arms, and designs for critical care comparative effectiveness research: It's complicated
CONCLUSION: Flawed critical care comparative effectiveness research trial designs can lead to unsound trial conclusions, compromise informed consent, and increase risks to research subjects, undermining the major goal of comparative effectiveness research: to inform current practice. Well-constructed control and comparator arms comprise indispensable elements of critical care comparative effectiveness research trials, key to improving the trials' safety and to generating trial results likely to improve patient outcomes in clinical practice.PMID:37615179 | DOI:10.1177/17407745231195094 (Source: Clinical Trials)
Source: Clinical Trials - August 24, 2023 Category: Research Authors: Verity J Ford Harvey G Klein Robert L Danner Willard N Applefeld Jeffrey Wang Irene Cortes-Puch Peter Q Eichacker Charles Natanson Source Type: research
Controls, comparator arms, and designs for critical care comparative effectiveness research: It's complicated
CONCLUSION: Flawed critical care comparative effectiveness research trial designs can lead to unsound trial conclusions, compromise informed consent, and increase risks to research subjects, undermining the major goal of comparative effectiveness research: to inform current practice. Well-constructed control and comparator arms comprise indispensable elements of critical care comparative effectiveness research trials, key to improving the trials' safety and to generating trial results likely to improve patient outcomes in clinical practice.PMID:37615179 | DOI:10.1177/17407745231195094 (Source: Clinical Trials)
Source: Clinical Trials - August 24, 2023 Category: Research Authors: Verity J Ford Harvey G Klein Robert L Danner Willard N Applefeld Jeffrey Wang Irene Cortes-Puch Peter Q Eichacker Charles Natanson Source Type: research
Controls, comparator arms, and designs for critical care comparative effectiveness research: It's complicated
CONCLUSION: Flawed critical care comparative effectiveness research trial designs can lead to unsound trial conclusions, compromise informed consent, and increase risks to research subjects, undermining the major goal of comparative effectiveness research: to inform current practice. Well-constructed control and comparator arms comprise indispensable elements of critical care comparative effectiveness research trials, key to improving the trials' safety and to generating trial results likely to improve patient outcomes in clinical practice.PMID:37615179 | DOI:10.1177/17407745231195094 (Source: Clinical Trials)
Source: Clinical Trials - August 24, 2023 Category: Research Authors: Verity J Ford Harvey G Klein Robert L Danner Willard N Applefeld Jeffrey Wang Irene Cortes-Puch Peter Q Eichacker Charles Natanson Source Type: research
Controls, comparator arms, and designs for critical care comparative effectiveness research: It's complicated
CONCLUSION: Flawed critical care comparative effectiveness research trial designs can lead to unsound trial conclusions, compromise informed consent, and increase risks to research subjects, undermining the major goal of comparative effectiveness research: to inform current practice. Well-constructed control and comparator arms comprise indispensable elements of critical care comparative effectiveness research trials, key to improving the trials' safety and to generating trial results likely to improve patient outcomes in clinical practice.PMID:37615179 | DOI:10.1177/17407745231195094 (Source: Clinical Trials)
Source: Clinical Trials - August 24, 2023 Category: Research Authors: Verity J Ford Harvey G Klein Robert L Danner Willard N Applefeld Jeffrey Wang Irene Cortes-Puch Peter Q Eichacker Charles Natanson Source Type: research
Controls, comparator arms, and designs for critical care comparative effectiveness research: It's complicated
CONCLUSION: Flawed critical care comparative effectiveness research trial designs can lead to unsound trial conclusions, compromise informed consent, and increase risks to research subjects, undermining the major goal of comparative effectiveness research: to inform current practice. Well-constructed control and comparator arms comprise indispensable elements of critical care comparative effectiveness research trials, key to improving the trials' safety and to generating trial results likely to improve patient outcomes in clinical practice.PMID:37615179 | DOI:10.1177/17407745231195094 (Source: Clinical Trials)
Source: Clinical Trials - August 24, 2023 Category: Research Authors: Verity J Ford Harvey G Klein Robert L Danner Willard N Applefeld Jeffrey Wang Irene Cortes-Puch Peter Q Eichacker Charles Natanson Source Type: research
Controls, comparator arms, and designs for critical care comparative effectiveness research: It's complicated
CONCLUSION: Flawed critical care comparative effectiveness research trial designs can lead to unsound trial conclusions, compromise informed consent, and increase risks to research subjects, undermining the major goal of comparative effectiveness research: to inform current practice. Well-constructed control and comparator arms comprise indispensable elements of critical care comparative effectiveness research trials, key to improving the trials' safety and to generating trial results likely to improve patient outcomes in clinical practice.PMID:37615179 | DOI:10.1177/17407745231195094 (Source: Clinical Trials)
Source: Clinical Trials - August 24, 2023 Category: Research Authors: Verity J Ford Harvey G Klein Robert L Danner Willard N Applefeld Jeffrey Wang Irene Cortes-Puch Peter Q Eichacker Charles Natanson Source Type: research
Controls, comparator arms, and designs for critical care comparative effectiveness research: It's complicated
CONCLUSION: Flawed critical care comparative effectiveness research trial designs can lead to unsound trial conclusions, compromise informed consent, and increase risks to research subjects, undermining the major goal of comparative effectiveness research: to inform current practice. Well-constructed control and comparator arms comprise indispensable elements of critical care comparative effectiveness research trials, key to improving the trials' safety and to generating trial results likely to improve patient outcomes in clinical practice.PMID:37615179 | DOI:10.1177/17407745231195094 (Source: Clinical Trials)
Source: Clinical Trials - August 24, 2023 Category: Research Authors: Verity J Ford Harvey G Klein Robert L Danner Willard N Applefeld Jeffrey Wang Irene Cortes-Puch Peter Q Eichacker Charles Natanson Source Type: research
Controls, comparator arms, and designs for critical care comparative effectiveness research: It's complicated
CONCLUSION: Flawed critical care comparative effectiveness research trial designs can lead to unsound trial conclusions, compromise informed consent, and increase risks to research subjects, undermining the major goal of comparative effectiveness research: to inform current practice. Well-constructed control and comparator arms comprise indispensable elements of critical care comparative effectiveness research trials, key to improving the trials' safety and to generating trial results likely to improve patient outcomes in clinical practice.PMID:37615179 | DOI:10.1177/17407745231195094 (Source: Clinical Trials)
Source: Clinical Trials - August 24, 2023 Category: Research Authors: Verity J Ford Harvey G Klein Robert L Danner Willard N Applefeld Jeffrey Wang Irene Cortes-Puch Peter Q Eichacker Charles Natanson Source Type: research
Assessing the use of observational methods and real-world data to emulate ongoing randomized controlled trials
CONCLUSION: Despite challenges, observational methods and real-world data can be leveraged in certain important situations for a more timely evaluation of drug effectiveness and safety in more diverse and representative patient populations.PMID:37589143 | DOI:10.1177/17407745231193137 (Source: Clinical Trials)
Source: Clinical Trials - August 17, 2023 Category: Research Authors: Joshua D Wallach Yihong Deng Eric C Polley Sanket S Dhruva Jeph Herrin Kenneth Quinto Charu Gandotra William Crown Peter Noseworthy Xiaoxi Yao Molly Moore Jeffery Timothy D Lyon Joseph S Ross Rozalina G McCoy Source Type: research
Assessing the use of observational methods and real-world data to emulate ongoing randomized controlled trials
CONCLUSION: Despite challenges, observational methods and real-world data can be leveraged in certain important situations for a more timely evaluation of drug effectiveness and safety in more diverse and representative patient populations.PMID:37589143 | DOI:10.1177/17407745231193137 (Source: Clinical Trials)
Source: Clinical Trials - August 17, 2023 Category: Research Authors: Joshua D Wallach Yihong Deng Eric C Polley Sanket S Dhruva Jeph Herrin Kenneth Quinto Charu Gandotra William Crown Peter Noseworthy Xiaoxi Yao Molly Moore Jeffery Timothy D Lyon Joseph S Ross Rozalina G McCoy Source Type: research
Assessing the use of observational methods and real-world data to emulate ongoing randomized controlled trials
CONCLUSION: Despite challenges, observational methods and real-world data can be leveraged in certain important situations for a more timely evaluation of drug effectiveness and safety in more diverse and representative patient populations.PMID:37589143 | DOI:10.1177/17407745231193137 (Source: Clinical Trials)
Source: Clinical Trials - August 17, 2023 Category: Research Authors: Joshua D Wallach Yihong Deng Eric C Polley Sanket S Dhruva Jeph Herrin Kenneth Quinto Charu Gandotra William Crown Peter Noseworthy Xiaoxi Yao Molly Moore Jeffery Timothy D Lyon Joseph S Ross Rozalina G McCoy Source Type: research
Assessing the use of observational methods and real-world data to emulate ongoing randomized controlled trials
CONCLUSION: Despite challenges, observational methods and real-world data can be leveraged in certain important situations for a more timely evaluation of drug effectiveness and safety in more diverse and representative patient populations.PMID:37589143 | DOI:10.1177/17407745231193137 (Source: Clinical Trials)
Source: Clinical Trials - August 17, 2023 Category: Research Authors: Joshua D Wallach Yihong Deng Eric C Polley Sanket S Dhruva Jeph Herrin Kenneth Quinto Charu Gandotra William Crown Peter Noseworthy Xiaoxi Yao Molly Moore Jeffery Timothy D Lyon Joseph S Ross Rozalina G McCoy Source Type: research
Assessing the use of observational methods and real-world data to emulate ongoing randomized controlled trials
CONCLUSION: Despite challenges, observational methods and real-world data can be leveraged in certain important situations for a more timely evaluation of drug effectiveness and safety in more diverse and representative patient populations.PMID:37589143 | DOI:10.1177/17407745231193137 (Source: Clinical Trials)
Source: Clinical Trials - August 17, 2023 Category: Research Authors: Joshua D Wallach Yihong Deng Eric C Polley Sanket S Dhruva Jeph Herrin Kenneth Quinto Charu Gandotra William Crown Peter Noseworthy Xiaoxi Yao Molly Moore Jeffery Timothy D Lyon Joseph S Ross Rozalina G McCoy Source Type: research
