Erratum: Prevalence of positive atopy patch test in an unselected pediatric population
No description available (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - July 7, 2015 Category: Allergy & Immunology Authors: Nicola FuianoGiuliana DiddiMaurizio DelvecchioCristoforo Incorvaia Source Type: research
Choosing wisely: practical considerations on treatment efficacy and safety of asthma in the elderly
The prevalence of asthma in the most advanced ages is similar to that of younger ages. However, the concept that older individuals may suffer from allergic asthma has been largely denied in the past, and a common belief attributes to asthma the definition of “rare” disease. Indeed, asthma in the elderly is often underdiagnosed or diagnosed as COPD, thus leading to undertreatment of improper treatment. This is also due to the heterogeneity of clinical and functional presentations of geriatric asthma, including the partial loss of reversibility and the lower occurrence of the allergic component in this age range. The old...
Source: Clinical and Molecular Allergy - June 22, 2015 Category: Allergy & Immunology Authors: Nicola ScichiloneMaria VenturaMatteo BoniniFulvio BraidoCaterina BuccaMarco CaminatiStefano Del GiaccoEnrico HefflerCarlo LombardiAndrea MatucciManlio MilaneseRoberto PaganelliGiovanni PassalacquaVincenzo PatellaErminia RidoloGiovanni RollaOliviero RossiD Source Type: research
Identification of risk factors of severe hypersensitivity reactions in general anaesthesia
Conclusions:
We confirmed the relevance of several clinical features as risk factors for anaphylactic reactions induced by anaesthetic agents: older age, asthma, hypertension and antihypertensive drugs. We observed increased levels of serum basal tryptase in severe reactions: this finding may signify that this biomarker is useful for the identification of patients at risk. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - June 22, 2015 Category: Allergy & Immunology Authors: Corrado MironeDonatella PreziosiAmbra MascheriGianluigi MicarelliLaura FarioliLuca BalossiJoseph ScibiliaJan SchroederLaura LosappioMaria AversanoChrysi StafylarakiMichele NichelattiElide Pastorello Source Type: research
T helper cell mediated-tolerance towards fetal allograft in successful pregnancy
Trophoblast HLA-C antigens from paternal origins, which liken the trophoblast to a semiallograft, could be presented by the maternal APCs to the specific maternal CD4+ T helper cells, which could release various cytokines in response to these alloantigens. On the basis of the cytokines produced, these cells can be classified in Th1, Th2 and Th17 cells. Th1 and Th17 cells, known to be responsible for acute allograft rejection, could be involved in miscarriage and Th2 cells together with regulatory CD4+ T cells, known to be involved in allograft tolerance, could be responsible, at least in part, for the success of pregnancy....
Source: Clinical and Molecular Allergy - June 10, 2015 Category: Allergy & Immunology Authors: Marie-Pierre PiccinniLetizia LombardelliFederica LogiodiceOrnela KullolliSergio RomagnaniPhilippe Le Bouteiller Source Type: research
Serum tryptase detected during acute coronary syndrome is significantly related to the development of major adverse cardiovascular events after 2 years
Background:
One of the greatest challenges in cardiovascular medicine is to define the best tools for performing an accurate risk stratification for the recurrence of ischemic events in acute coronary syndrome (ACS) patients.
Methods:
We followed 65 ACS patients enrolled in a previous pilot study for 2 years after being discharged, focusing on the occurrence of major adverse cardiovascular events (MACE).The relationship between serum tryptase levels on admission, SYNergy between percutaneous coronary intervention with the TAXUS drug-eluting stent and the cardiac surgery score (SX-score), cardiovascular complexity and MACE...
Source: Clinical and Molecular Allergy - June 2, 2015 Category: Allergy & Immunology Authors: Elide PastorelloLaura FarioliLaura LosappioNuccia MoriciMatteo Di BiaseMichele NichelattiJan SchroederLuca BalossiSilvio Klugmann Source Type: research
Pidotimod: the state of art
Despite the use of antibiotics and vaccines, the frequency of respiratory tract infections is still high and these infections interest a wide range of patients, from children to aged people, including in particular these extreme categories because of the deficiency of their immune system, due to immaturity in the former case and to “immunosenescence” in the latter. For that reason immunostimulant drugs are getting more important to prevent and to attenuate infections. Pidotimod (3-L-pyroglutamyl-L-thiazolidine-4carboxylic acid) is a synthetic dipeptide with immunomodulatory properties. We reviewed studies conducted on ...
Source: Clinical and Molecular Allergy - May 21, 2015 Category: Allergy & Immunology Authors: Beatrice FerrarioSilvia GarutiFulvio BraidoGiorgio Canonica Source Type: research
European medicines agency guideline for biological medicinal products: a further step for a safe use of biosimilars
No description available (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - May 15, 2015 Category: Allergy & Immunology Authors: Carlo AgostiniGiorgio CanonicaEnrico Maggi Source Type: research
Prevalence of positive atopy patch test in an unselected pediatric population
Conclusions:
This survey on an unselected population of children detected a prevalence of positive results to atopy patch test not so distant from the positive results to skin prick test, and in 8.8 % of subjects the atopy patch test was the only positive test. This would suggest to add the atopy patch test in future epidemiological studies on allergy, in order to avoid to overlook the not negligible portion of patients with T-cell-mediated allergy. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - May 7, 2015 Category: Allergy & Immunology Authors: Nicola FuianoGiuliana DiddiMaurizio DelvecchioCristoforo C Source Type: research
The perception of Obstructive Sleep Apnoea/Hypopnoea Syndrome (OSAHS) among Italian general practitioners
Conclusions:
In conclusion, this survey about the perception of OSAHS among GPs in Italy highlighted a satisfactory overall knowledge of OSAHS and only few weak points. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - April 15, 2015 Category: Allergy & Immunology Authors: Carlo LombardiEleonora MusiccoGermano BettoncelliManlio MilaneseGianenrico SennaFulvio BraidoGiorgio Canonica Source Type: research
Welcome to a new era for Clinical and Molecular Allergy
No description available (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - April 15, 2015 Category: Allergy & Immunology Authors: Enrico Maggi Source Type: research
Remission of severe aphthous stomatitis of celiac disease with etanercept
We present a patient with celiac disease complicated by severe aphthous stomatitis resulting in impairing swallowing, chewing and speaking. This led to weight loss, psychosocial problems as well as inability to perform her work. A variety of topical and systemic medications used resulted in either no improvement or only partial alleviation of the patient's symptoms. After informed consent, etanercept was initiated and resulted in complete remission of aphthous stomatitis, decrease in arthralgia and fatigue and considerable improvement in her quality of life. The use of newer biological agents for selected and severe manife...
Source: Clinical and Molecular Allergy - December 24, 2013 Category: Allergy & Immunology Authors: Adey HasanHiren PatelGeorge YoungbergJohn LitchfieldGuha Krishnaswamy Source Type: research
The silent sinus syndrome: protean manifestations of a rare upper respiratory disorder revisited
Silent Sinus Syndrome (SSS) is known to be a rare clinical condition, characterized by spontaneous and progressive enophthalmos and hypoglobus associated with atelectasis of the maxillary sinus and alteration of the orbital floor. Most of the patients with this syndrome present with ophthalmological complaints without any nasal sinus symptoms, and it typically has a painless course and slow development, ergo the term "silent." Here we present a case report of a patient with occasional coughing spells as the presenting symptom of Silent Sinus Syndrome, which has not been previously described in the literature. The CT scan f...
Source: Clinical and Molecular Allergy - December 9, 2013 Category: Allergy & Immunology Authors: Denisse GuillenPaulette PinargoteJuan Guarderas Source Type: research
The retinoic acid receptor-¿ modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression
Conclusions:
We report that the reciprocal regulation of Th2 cytokine expression and proliferation by RARα modulators are largely limited to modulation of IL-5 gene expression and to proliferation of the highly differentiated IL-5+ Th2 subpopulation. These results suggest that RARα antagonism is a potential means to therapeutically target allergic inflammation.Trial registrationClinicaltrials.gov identifier: NCT01212016 (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - December 6, 2013 Category: Allergy & Immunology Authors: Daniel WansleyYuzhi YinCalman Prussin Source Type: research
The retinoic acid receptor-alpha modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression
Conclusions:
We report that the reciprocal regulation of Th2 cytokine expression and proliferation by RARalpha modulators are largely limited to modulation of IL-5 gene expression and to proliferation of the highly differentiated IL-5+ Th2 subpopulation. These results suggest that RARalpha antagonism is a potential means to therapeutically target allergic inflammation.Trial registration: Clinicaltrials.gov identifier: NCT01212016 (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - December 6, 2013 Category: Allergy & Immunology Authors: Daniel WansleyYuzhi YinCalman Prussin Source Type: research
Association between a low IgE response to Phl p 5 and absence of asthma in patients with grass pollen allergy
Conclusions:
This preliminary finding suggests that low values of sIgE to Phl p 5 are correlated with the absence of asthma in patients with grass-pollen induced allergy. The data, provided they are confirmed by further studies, could be useful when selecting patients who are candidates for allergen immunotherapy, since a higher risk of asthma could be used as a selection criterion for using this approach. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - December 5, 2013 Category: Allergy & Immunology Authors: Eleonora SaviSilvia PeveriCristoforo IncorvaiaIlaria Dell¿AlbaniFrancesco MarcucciGiuseppe Di CaraFranco Frati Source Type: research
