Advancements in Perovskite-Based Cathode Materials for Solid Oxide Fuel Cells: A Comprehensive Review
Chem Rec. 2023 Nov 7:e202300247. doi: 10.1002/tcr.202300247. Online ahead of print.ABSTRACTThe high-temperature solid oxide fuel cells (SOFCs) are the most efficient and green conversion technology for electricity generation from hydrogen-based fuel as compared to conventional thermal power plants. Many efforts have been made to reduce the high operating temperature (>800 °C) to intermediate/low operating temperature (400 °C<T<800 °C) in SOFCs in order to extend their life span, thermal compatibility, cost-effectiveness, and ease of fabrication. However, the major challenges in developing cathode materials for ...
Source: Chemical Record - November 7, 2023 Category: Chemistry Authors: Ayesha Samreen Muhammad Sudais Ali Muhammad Huzaifa Nasir Ali Bilal Hassan Fazl Ullah Shahid Ali Nor Anisa Arifin Source Type: research
Navigating α-Synuclein Aggregation Inhibition: Methods, Mechanisms, and Molecular Targets
Chem Rec. 2023 Nov 2:e202300282. doi: 10.1002/tcr.202300282. Online ahead of print.ABSTRACTParkinson's disease is a yet incurable, age-related neurodegenerative disorder characterized by the aggregation of small neuronal protein α-synuclein into amyloid fibrils. Inhibition of this process is a prospective strategy for developing a disease-modifying treatment. We overview here small molecule, peptide, and protein inhibitors of α-synuclein fibrillization reported to date. Special attention was paid to the specificity of inhibitors and critical analysis of their action mechanisms. Namely, the importance of oxidation of poly...
Source: Chemical Record - November 2, 2023 Category: Chemistry Authors: Maksym Galkin Anastasiia Priss Yevhenii Kyriukha Volodymyr Shvadchak Source Type: research
Navigating α-Synuclein Aggregation Inhibition: Methods, Mechanisms, and Molecular Targets
Chem Rec. 2023 Nov 2:e202300282. doi: 10.1002/tcr.202300282. Online ahead of print.ABSTRACTParkinson's disease is a yet incurable, age-related neurodegenerative disorder characterized by the aggregation of small neuronal protein α-synuclein into amyloid fibrils. Inhibition of this process is a prospective strategy for developing a disease-modifying treatment. We overview here small molecule, peptide, and protein inhibitors of α-synuclein fibrillization reported to date. Special attention was paid to the specificity of inhibitors and critical analysis of their action mechanisms. Namely, the importance of oxidation of poly...
Source: Chemical Record - November 2, 2023 Category: Chemistry Authors: Maksym Galkin Anastasiia Priss Yevhenii Kyriukha Volodymyr Shvadchak Source Type: research
Navigating α-Synuclein Aggregation Inhibition: Methods, Mechanisms, and Molecular Targets
Chem Rec. 2023 Nov 2:e202300282. doi: 10.1002/tcr.202300282. Online ahead of print.ABSTRACTParkinson's disease is a yet incurable, age-related neurodegenerative disorder characterized by the aggregation of small neuronal protein α-synuclein into amyloid fibrils. Inhibition of this process is a prospective strategy for developing a disease-modifying treatment. We overview here small molecule, peptide, and protein inhibitors of α-synuclein fibrillization reported to date. Special attention was paid to the specificity of inhibitors and critical analysis of their action mechanisms. Namely, the importance of oxidation of poly...
Source: Chemical Record - November 2, 2023 Category: Chemistry Authors: Maksym Galkin Anastasiia Priss Yevhenii Kyriukha Volodymyr Shvadchak Source Type: research
Navigating α-Synuclein Aggregation Inhibition: Methods, Mechanisms, and Molecular Targets
Chem Rec. 2023 Nov 2:e202300282. doi: 10.1002/tcr.202300282. Online ahead of print.ABSTRACTParkinson's disease is a yet incurable, age-related neurodegenerative disorder characterized by the aggregation of small neuronal protein α-synuclein into amyloid fibrils. Inhibition of this process is a prospective strategy for developing a disease-modifying treatment. We overview here small molecule, peptide, and protein inhibitors of α-synuclein fibrillization reported to date. Special attention was paid to the specificity of inhibitors and critical analysis of their action mechanisms. Namely, the importance of oxidation of poly...
Source: Chemical Record - November 2, 2023 Category: Chemistry Authors: Maksym Galkin Anastasiia Priss Yevhenii Kyriukha Volodymyr Shvadchak Source Type: research
Recyclization of 5-Amino- oxazoles as a Route to new Functionalized Heterocycles (Developments of V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine)
Chem Rec. 2023 Oct 26:e202300264. doi: 10.1002/tcr.202300264. Online ahead of print.ABSTRACTThe recyclizations of 5-amino- and 5-hydrazine-1,3-oxazoles mainly with electron-withdrawing group in 4th position are considered. The chemical behavior of these heterocycles is due to the presence of two hidden amide fragments; therefore, the recyclization processes include a stage of nucleophile attack on 2nd or 5th position of the oxazole cycle. When the nitrile group is present in 4th position, it is often involved in the recyclization forming α-aminoazoles. 5-Amino/hydrazine-1,3-oxazoles undergo recyclization both in nucleophi...
Source: Chemical Record - October 26, 2023 Category: Chemistry Authors: Oleh V Shablykin Volodymyr S Brovarets Olga V Shablykina Source Type: research
Recyclization of 5-Amino- oxazoles as a Route to new Functionalized Heterocycles (Developments of V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine)
Chem Rec. 2023 Oct 26:e202300264. doi: 10.1002/tcr.202300264. Online ahead of print.ABSTRACTThe recyclizations of 5-amino- and 5-hydrazine-1,3-oxazoles mainly with electron-withdrawing group in 4th position are considered. The chemical behavior of these heterocycles is due to the presence of two hidden amide fragments; therefore, the recyclization processes include a stage of nucleophile attack on 2nd or 5th position of the oxazole cycle. When the nitrile group is present in 4th position, it is often involved in the recyclization forming α-aminoazoles. 5-Amino/hydrazine-1,3-oxazoles undergo recyclization both in nucleophi...
Source: Chemical Record - October 26, 2023 Category: Chemistry Authors: Oleh V Shablykin Volodymyr S Brovarets Olga V Shablykina Source Type: research
Recyclization of 5-Amino- oxazoles as a Route to new Functionalized Heterocycles (Developments of V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine)
Chem Rec. 2023 Oct 26:e202300264. doi: 10.1002/tcr.202300264. Online ahead of print.ABSTRACTThe recyclizations of 5-amino- and 5-hydrazine-1,3-oxazoles mainly with electron-withdrawing group in 4th position are considered. The chemical behavior of these heterocycles is due to the presence of two hidden amide fragments; therefore, the recyclization processes include a stage of nucleophile attack on 2nd or 5th position of the oxazole cycle. When the nitrile group is present in 4th position, it is often involved in the recyclization forming α-aminoazoles. 5-Amino/hydrazine-1,3-oxazoles undergo recyclization both in nucleophi...
Source: Chemical Record - October 26, 2023 Category: Chemistry Authors: Oleh V Shablykin Volodymyr S Brovarets Olga V Shablykina Source Type: research
Recyclization of 5-Amino- oxazoles as a Route to new Functionalized Heterocycles (Developments of V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine)
Chem Rec. 2023 Oct 26:e202300264. doi: 10.1002/tcr.202300264. Online ahead of print.ABSTRACTThe recyclizations of 5-amino- and 5-hydrazine-1,3-oxazoles mainly with electron-withdrawing group in 4th position are considered. The chemical behavior of these heterocycles is due to the presence of two hidden amide fragments; therefore, the recyclization processes include a stage of nucleophile attack on 2nd or 5th position of the oxazole cycle. When the nitrile group is present in 4th position, it is often involved in the recyclization forming α-aminoazoles. 5-Amino/hydrazine-1,3-oxazoles undergo recyclization both in nucleophi...
Source: Chemical Record - October 26, 2023 Category: Chemistry Authors: Oleh V Shablykin Volodymyr S Brovarets Olga V Shablykina Source Type: research
Recyclization of 5-Amino- oxazoles as a Route to new Functionalized Heterocycles (Developments of V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine)
Chem Rec. 2023 Oct 26:e202300264. doi: 10.1002/tcr.202300264. Online ahead of print.ABSTRACTThe recyclizations of 5-amino- and 5-hydrazine-1,3-oxazoles mainly with electron-withdrawing group in 4th position are considered. The chemical behavior of these heterocycles is due to the presence of two hidden amide fragments; therefore, the recyclization processes include a stage of nucleophile attack on 2nd or 5th position of the oxazole cycle. When the nitrile group is present in 4th position, it is often involved in the recyclization forming α-aminoazoles. 5-Amino/hydrazine-1,3-oxazoles undergo recyclization both in nucleophi...
Source: Chemical Record - October 26, 2023 Category: Chemistry Authors: Oleh V Shablykin Volodymyr S Brovarets Olga V Shablykina Source Type: research
Recyclization of 5-Amino- oxazoles as a Route to new Functionalized Heterocycles (Developments of V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine)
Chem Rec. 2023 Oct 26:e202300264. doi: 10.1002/tcr.202300264. Online ahead of print.ABSTRACTThe recyclizations of 5-amino- and 5-hydrazine-1,3-oxazoles mainly with electron-withdrawing group in 4th position are considered. The chemical behavior of these heterocycles is due to the presence of two hidden amide fragments; therefore, the recyclization processes include a stage of nucleophile attack on 2nd or 5th position of the oxazole cycle. When the nitrile group is present in 4th position, it is often involved in the recyclization forming α-aminoazoles. 5-Amino/hydrazine-1,3-oxazoles undergo recyclization both in nucleophi...
Source: Chemical Record - October 26, 2023 Category: Chemistry Authors: Oleh V Shablykin Volodymyr S Brovarets Olga V Shablykina Source Type: research
Recyclization of 5-Amino- oxazoles as a Route to new Functionalized Heterocycles (Developments of V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine)
Chem Rec. 2023 Oct 26:e202300264. doi: 10.1002/tcr.202300264. Online ahead of print.ABSTRACTThe recyclizations of 5-amino- and 5-hydrazine-1,3-oxazoles mainly with electron-withdrawing group in 4th position are considered. The chemical behavior of these heterocycles is due to the presence of two hidden amide fragments; therefore, the recyclization processes include a stage of nucleophile attack on 2nd or 5th position of the oxazole cycle. When the nitrile group is present in 4th position, it is often involved in the recyclization forming α-aminoazoles. 5-Amino/hydrazine-1,3-oxazoles undergo recyclization both in nucleophi...
Source: Chemical Record - October 26, 2023 Category: Chemistry Authors: Oleh V Shablykin Volodymyr S Brovarets Olga V Shablykina Source Type: research
Aza-Heterocyclic Building Blocks with In-Ring CF < sub > 2 < /sub > -Fragment
Chem Rec. 2023 Oct 24:e202300283. doi: 10.1002/tcr.202300283. Online ahead of print.ABSTRACTModern organic chemistry is a titan supporting and reinforcing pharmaceutical, agricultural, food and material science products. Over the past decades, the organic compounds market has been evolving to meet all the research demands. In this regard, medicinal chemistry is especially dependent on available chemical space as subtle tuning of the molecule structure is required to create a drug with relevant physicochemical properties and a remarkable activity profile. The recent rapid evolution of synthetic methodology to deploy fluorin...
Source: Chemical Record - October 24, 2023 Category: Chemistry Authors: S V Ryabukhin D V Bondarenko S A Trofymchuk D A Lega D M Volochnyuk Source Type: research
Excitonic Properties of Organic Dye Aggregates: Contribution of Ukrainian Science
Chem Rec. 2023 Oct 24:e202300290. doi: 10.1002/tcr.202300290. Online ahead of print.ABSTRACTUnexpected discovery that molecules of organic dyes when they form regular structures can change dramatically their light absorption and fluorescence properties were attracting the minds of researchers for more than eight decades. The progress in investigation of this unique phenomenon described in terms of H- and J-aggregation has led to many practical applications. Here the author expresses his personal view on the dramatic story of switching this research area from empirical knowledge to that standing on strong background of mole...
Source: Chemical Record - October 24, 2023 Category: Chemistry Authors: Alexander P Demchenko Source Type: research
Recent Theoretical and Experimental Advancements of Aluminum-Sulfur Batteries
Chem Rec. 2023 Oct 24:e202300268. doi: 10.1002/tcr.202300268. Online ahead of print.ABSTRACTAluminum-sulfur batteries (AlSBs) exhibit significant potential as energy storage systems due to their notable attributes, including a high energy density, cost-effectiveness, and abundant availability of aluminum and sulfur. In order to commercialize AlSBs, an understanding of their working principles is necessary. In this review, we examine the current advancements in cathodes, both in theory and practice, as well as the progress made in aqueous and nonaqueous electrolytes. We also explore the modifications made to separators and ...
Source: Chemical Record - October 24, 2023 Category: Chemistry Authors: Muhammad Faheem Arshad Hussain Muhammad Ali Md Abdul Aziz Source Type: research
