Lamin A K97E leads to NF- κB-mediated dysfunction of inflammatory responses in dilated cardiomyopathy
CONCLUSIONS: We report here for the first time that there is a significant downregulation of the NF-κB pathway, which has been implicated in cardio-protection elsewhere.SIGNIFICANCE: This provides a new pathophysiological explanation that correlates an LMNA mutation and dilated cardiomyopathy.PMID:38404031 | DOI:10.1111/boc.202300094 (Source: Biology of the Cell)
Source: Biology of the Cell - February 26, 2024 Category: Cytology Authors: Duhita Sengupta Kaushik Sengupta Source Type: research
Diosgenyl glucosamine conjugates increase pro-apoptotic and selective activities in cancer cell lines
CONCLUSIONS: Altogether, these results demonstrate that diosgenin glucosamine compounds exert an antiproliferative effect on cancer cell lines and induce apoptotic effects more efficiently than diosgenin alone without affecting non-tumour cells.SIGNIFICANCE: This study evidences the pro-apoptotic and selective activities of diosgenyl glucosamine compounds in cancer cell lines.PMID:38408271 | DOI:10.1111/boc.202300052 (Source: Biology of the Cell)
Source: Biology of the Cell - February 26, 2024 Category: Cytology Authors: Mart ínez Mata Sergio Iván Escobar S ánchez María Luisa L ópez Muñoz Hugo Hilario Mart ínez Jazmín Ciciolil Sandoval Ram írez Jesús Aparicio S ánchez Uriel Yair S ánchez Sánchez Luis Source Type: research
Lamin A K97E leads to NF- κB-mediated dysfunction of inflammatory responses in dilated cardiomyopathy
CONCLUSIONS: We report here for the first time that there is a significant downregulation of the NF-κB pathway, which has been implicated in cardio-protection elsewhere.SIGNIFICANCE: This provides a new pathophysiological explanation that correlates an LMNA mutation and dilated cardiomyopathy.PMID:38404031 | DOI:10.1111/boc.202300094 (Source: Biology of the Cell)
Source: Biology of the Cell - February 26, 2024 Category: Cytology Authors: Duhita Sengupta Kaushik Sengupta Source Type: research
To squeeze or not: Regulation of cell size by mechanical forces in development and human diseases
Biol Cell. 2024 Feb;116(2):e2200101. doi: 10.1111/boc.202200101. Epub 2023 Dec 15.ABSTRACTPhysical constraints, such as compression, shear stress, stretching and tension play major roles during development and tissue homeostasis. Mechanics directly impact physiology, and their alteration is also recognized as having an active role in driving human diseases. Recently, growing evidence has accumulated on how mechanical forces are translated into a wide panel of biological responses, including metabolism and changes in cell morphology. The aim of this review is to summarize and discuss our knowledge on the impact of mechanica...
Source: Biology of the Cell - December 7, 2023 Category: Cytology Authors: Aurore Claude-Taupin Nicolas Dupont Source Type: research
To squeeze or not: Regulation of cell size by mechanical forces in development and human diseases
Biol Cell. 2023 Dec 7:e2200101. doi: 10.1111/boc.202200101. Online ahead of print.ABSTRACTPhysical constraints, such as compression, shear stress, stretching and tension play major roles during development and tissue homeostasis. Mechanics directly impact physiology, and their alteration is also recognized as having an active role in driving human diseases. Recently, growing evidence has accumulated on how mechanical forces are translated into a wide panel of biological responses, including metabolism and changes in cell morphology. The aim of this review is to summarize and discuss our knowledge on the impact of mechanica...
Source: Biology of the Cell - December 7, 2023 Category: Cytology Authors: Aurore Claude-Taupin Nicolas Dupont Source Type: research
To squeeze or not: Regulation of cell size by mechanical forces in development and human diseases
Biol Cell. 2023 Dec 7:e2200101. doi: 10.1111/boc.202200101. Online ahead of print.ABSTRACTPhysical constraints, such as compression, shear stress, stretching and tension play major roles during development and tissue homeostasis. Mechanics directly impact physiology, and their alteration is also recognized as having an active role in driving human diseases. Recently, growing evidence has accumulated on how mechanical forces are translated into a wide panel of biological responses, including metabolism and changes in cell morphology. The aim of this review is to summarize and discuss our knowledge on the impact of mechanica...
Source: Biology of the Cell - December 7, 2023 Category: Cytology Authors: Aurore Claude-Taupin Nicolas Dupont Source Type: research
To squeeze or not: Regulation of cell size by mechanical forces in development and human diseases
Biol Cell. 2023 Dec 7:e2200101. doi: 10.1111/boc.202200101. Online ahead of print.ABSTRACTPhysical constraints, such as compression, shear stress, stretching and tension play major roles during development and tissue homeostasis. Mechanics directly impact physiology, and their alteration is also recognized as having an active role in driving human diseases. Recently, growing evidence has accumulated on how mechanical forces are translated into a wide panel of biological responses, including metabolism and changes in cell morphology. The aim of this review is to summarize and discuss our knowledge on the impact of mechanica...
Source: Biology of the Cell - December 7, 2023 Category: Cytology Authors: Aurore Claude-Taupin Nicolas Dupont Source Type: research
To squeeze or not: Regulation of cell size by mechanical forces in development and human diseases
Biol Cell. 2023 Dec 7:e2200101. doi: 10.1111/boc.202200101. Online ahead of print.ABSTRACTPhysical constraints, such as compression, shear stress, stretching and tension play major roles during development and tissue homeostasis. Mechanics directly impact physiology, and their alteration is also recognized as having an active role in driving human diseases. Recently, growing evidence has accumulated on how mechanical forces are translated into a wide panel of biological responses, including metabolism and changes in cell morphology. The aim of this review is to summarize and discuss our knowledge on the impact of mechanica...
Source: Biology of the Cell - December 7, 2023 Category: Cytology Authors: Aurore Claude-Taupin Nicolas Dupont Source Type: research
To squeeze or not: Regulation of cell size by mechanical forces in development and human diseases
Biol Cell. 2023 Dec 7:e2200101. doi: 10.1111/boc.202200101. Online ahead of print.ABSTRACTPhysical constraints, such as compression, shear stress, stretching and tension play major roles during development and tissue homeostasis. Mechanics directly impact physiology, and their alteration is also recognized as having an active role in driving human diseases. Recently, growing evidence has accumulated on how mechanical forces are translated into a wide panel of biological responses, including metabolism and changes in cell morphology. The aim of this review is to summarize and discuss our knowledge on the impact of mechanica...
Source: Biology of the Cell - December 7, 2023 Category: Cytology Authors: Aurore Claude-Taupin Nicolas Dupont Source Type: research
To squeeze or not: Regulation of cell size by mechanical forces in development and human diseases
Biol Cell. 2023 Dec 7:e2200101. doi: 10.1111/boc.202200101. Online ahead of print.ABSTRACTPhysical constraints, such as compression, shear stress, stretching and tension play major roles during development and tissue homeostasis. Mechanics directly impact physiology, and their alteration is also recognized as having an active role in driving human diseases. Recently, growing evidence has accumulated on how mechanical forces are translated into a wide panel of biological responses, including metabolism and changes in cell morphology. The aim of this review is to summarize and discuss our knowledge on the impact of mechanica...
Source: Biology of the Cell - December 7, 2023 Category: Cytology Authors: Aurore Claude-Taupin Nicolas Dupont Source Type: research
To squeeze or not: Regulation of cell size by mechanical forces in development and human diseases
Biol Cell. 2023 Dec 7:e2200101. doi: 10.1111/boc.202200101. Online ahead of print.ABSTRACTPhysical constraints, such as compression, shear stress, stretching and tension play major roles during development and tissue homeostasis. Mechanics directly impact physiology, and their alteration is also recognized as having an active role in driving human diseases. Recently, growing evidence has accumulated on how mechanical forces are translated into a wide panel of biological responses, including metabolism and changes in cell morphology. The aim of this review is to summarize and discuss our knowledge on the impact of mechanica...
Source: Biology of the Cell - December 7, 2023 Category: Cytology Authors: Aurore Claude-Taupin Nicolas Dupont Source Type: research
To squeeze or not: Regulation of cell size by mechanical forces in development and human diseases
Biol Cell. 2023 Dec 7:e2200101. doi: 10.1111/boc.202200101. Online ahead of print.ABSTRACTPhysical constraints, such as compression, shear stress, stretching and tension play major roles during development and tissue homeostasis. Mechanics directly impact physiology, and their alteration is also recognized as having an active role in driving human diseases. Recently, growing evidence has accumulated on how mechanical forces are translated into a wide panel of biological responses, including metabolism and changes in cell morphology. The aim of this review is to summarize and discuss our knowledge on the impact of mechanica...
Source: Biology of the Cell - December 7, 2023 Category: Cytology Authors: Aurore Claude-Taupin Nicolas Dupont Source Type: research
To squeeze or not: Regulation of cell size by mechanical forces in development and human diseases
Biol Cell. 2023 Dec 7:e2200101. doi: 10.1111/boc.202200101. Online ahead of print.ABSTRACTPhysical constraints, such as compression, shear stress, stretching and tension play major roles during development and tissue homeostasis. Mechanics directly impact physiology, and their alteration is also recognized as having an active role in driving human diseases. Recently, growing evidence has accumulated on how mechanical forces are translated into a wide panel of biological responses, including metabolism and changes in cell morphology. The aim of this review is to summarize and discuss our knowledge on the impact of mechanica...
Source: Biology of the Cell - December 7, 2023 Category: Cytology Authors: Aurore Claude-Taupin Nicolas Dupont Source Type: research
To squeeze or not: Regulation of cell size by mechanical forces in development and human diseases
Biol Cell. 2023 Dec 7:e2200101. doi: 10.1111/boc.202200101. Online ahead of print.ABSTRACTPhysical constraints, such as compression, shear stress, stretching and tension play major roles during development and tissue homeostasis. Mechanics directly impact physiology, and their alteration is also recognized as having an active role in driving human diseases. Recently, growing evidence has accumulated on how mechanical forces are translated into a wide panel of biological responses, including metabolism and changes in cell morphology. The aim of this review is to summarize and discuss our knowledge on the impact of mechanica...
Source: Biology of the Cell - December 7, 2023 Category: Cytology Authors: Aurore Claude-Taupin Nicolas Dupont Source Type: research
To squeeze or not: Regulation of cell size by mechanical forces in development and human diseases
Biol Cell. 2023 Dec 7:e2200101. doi: 10.1111/boc.202200101. Online ahead of print.ABSTRACTPhysical constraints, such as compression, shear stress, stretching and tension play major roles during development and tissue homeostasis. Mechanics directly impact physiology, and their alteration is also recognized as having an active role in driving human diseases. Recently, growing evidence has accumulated on how mechanical forces are translated into a wide panel of biological responses, including metabolism and changes in cell morphology. The aim of this review is to summarize and discuss our knowledge on the impact of mechanica...
Source: Biology of the Cell - December 7, 2023 Category: Cytology Authors: Aurore Claude-Taupin Nicolas Dupont Source Type: research
