DUSP3 modulates IRES-dependent translation of mRNAs through dephosphorylation of the HNRNPC protein in cells under genotoxic stimulus
CONCLUSIONS AND SIGNIFICANCE: Overall, DUSP3 can modulate cellular responses to genotoxic stimuli at the translational level by maintaining the stability of HNRNPC-ITAF complexes and regulating the intensity and specificity of RNA interactions with RRM-domain proteins.PMID:38538536 | DOI:10.1111/boc.202300128 (Source: Biology of the Cell)
Source: Biology of the Cell - March 27, 2024 Category: Cytology Authors: Pault Y M Ferruzo Viktor K Boell Lilian C Russo Carla C Oliveira Fabio L Forti Source Type: research
Deletion of Dictyostelium tpc2 gene forms multi-tipped structures, regulates autophagy and cell-type patterning
CONCLUSION: TPC2 is required for effective development and differentiation in Dictyostelium and supports autophagic cell death and cell-type patterning.SIGNIFICANCE: Decreased calcium due to deletion of tpc2 inhibit autophagic flux.PMID:38537110 | DOI:10.1111/boc.202300067 (Source: Biology of the Cell)
Source: Biology of the Cell - March 27, 2024 Category: Cytology Authors: Madhubala Rathore Ashima Thakur Shweta Saran Source Type: research
DUSP3 modulates IRES-dependent translation of mRNAs through dephosphorylation of the HNRNPC protein in cells under genotoxic stimulus
CONCLUSIONS AND SIGNIFICANCE: Overall, DUSP3 can modulate cellular responses to genotoxic stimuli at the translational level by maintaining the stability of HNRNPC-ITAF complexes and regulating the intensity and specificity of RNA interactions with RRM-domain proteins.PMID:38538536 | DOI:10.1111/boc.202300128 (Source: Biology of the Cell)
Source: Biology of the Cell - March 27, 2024 Category: Cytology Authors: Pault Y M Ferruzo Viktor K Boell Lilian C Russo Carla C Oliveira Fabio L Forti Source Type: research
Deletion of Dictyostelium tpc2 gene forms multi-tipped structures, regulates autophagy and cell-type patterning
CONCLUSION: TPC2 is required for effective development and differentiation in Dictyostelium and supports autophagic cell death and cell-type patterning.SIGNIFICANCE: Decreased calcium due to deletion of tpc2 inhibit autophagic flux.PMID:38537110 | DOI:10.1111/boc.202300067 (Source: Biology of the Cell)
Source: Biology of the Cell - March 27, 2024 Category: Cytology Authors: Madhubala Rathore Ashima Thakur Shweta Saran Source Type: research
DUSP3 modulates IRES-dependent translation of mRNAs through dephosphorylation of the HNRNPC protein in cells under genotoxic stimulus
CONCLUSIONS AND SIGNIFICANCE: Overall, DUSP3 can modulate cellular responses to genotoxic stimuli at the translational level by maintaining the stability of HNRNPC-ITAF complexes and regulating the intensity and specificity of RNA interactions with RRM-domain proteins.PMID:38538536 | DOI:10.1111/boc.202300128 (Source: Biology of the Cell)
Source: Biology of the Cell - March 27, 2024 Category: Cytology Authors: Pault Y M Ferruzo Viktor K Boell Lilian C Russo Carla C Oliveira Fabio L Forti Source Type: research
Deletion of Dictyostelium tpc2 gene forms multi-tipped structures, regulates autophagy and cell-type patterning
CONCLUSION: TPC2 is required for effective development and differentiation in Dictyostelium and supports autophagic cell death and cell-type patterning.SIGNIFICANCE: Decreased calcium due to deletion of tpc2 inhibit autophagic flux.PMID:38537110 | DOI:10.1111/boc.202300067 (Source: Biology of the Cell)
Source: Biology of the Cell - March 27, 2024 Category: Cytology Authors: Madhubala Rathore Ashima Thakur Shweta Saran Source Type: research
DUSP3 modulates IRES-dependent translation of mRNAs through dephosphorylation of the HNRNPC protein in cells under genotoxic stimulus
CONCLUSIONS AND SIGNIFICANCE: Overall, DUSP3 can modulate cellular responses to genotoxic stimuli at the translational level by maintaining the stability of HNRNPC-ITAF complexes and regulating the intensity and specificity of RNA interactions with RRM-domain proteins.PMID:38538536 | DOI:10.1111/boc.202300128 (Source: Biology of the Cell)
Source: Biology of the Cell - March 27, 2024 Category: Cytology Authors: Pault Y M Ferruzo Viktor K Boell Lilian C Russo Carla C Oliveira Fabio L Forti Source Type: research
Deletion of Dictyostelium tpc2 gene forms multi-tipped structures, regulates autophagy and cell-type patterning
CONCLUSION: TPC2 is required for effective development and differentiation in Dictyostelium and supports autophagic cell death and cell-type patterning.SIGNIFICANCE: Decreased calcium due to deletion of tpc2 inhibit autophagic flux.PMID:38537110 | DOI:10.1111/boc.202300067 (Source: Biology of the Cell)
Source: Biology of the Cell - March 27, 2024 Category: Cytology Authors: Madhubala Rathore Ashima Thakur Shweta Saran Source Type: research
DUSP3 modulates IRES-dependent translation of mRNAs through dephosphorylation of the HNRNPC protein in cells under genotoxic stimulus
CONCLUSIONS AND SIGNIFICANCE: Overall, DUSP3 can modulate cellular responses to genotoxic stimuli at the translational level by maintaining the stability of HNRNPC-ITAF complexes and regulating the intensity and specificity of RNA interactions with RRM-domain proteins.PMID:38538536 | DOI:10.1111/boc.202300128 (Source: Biology of the Cell)
Source: Biology of the Cell - March 27, 2024 Category: Cytology Authors: Pault Y M Ferruzo Viktor K Boell Lilian C Russo Carla C Oliveira Fabio L Forti Source Type: research
Deletion of Dictyostelium tpc2 gene forms multi-tipped structures, regulates autophagy and cell-type patterning
CONCLUSION: TPC2 is required for effective development and differentiation in Dictyostelium and supports autophagic cell death and cell-type patterning.SIGNIFICANCE: Decreased calcium due to deletion of tpc2 inhibit autophagic flux.PMID:38537110 | DOI:10.1111/boc.202300067 (Source: Biology of the Cell)
Source: Biology of the Cell - March 27, 2024 Category: Cytology Authors: Madhubala Rathore Ashima Thakur Shweta Saran Source Type: research
DUSP3 modulates IRES-dependent translation of mRNAs through dephosphorylation of the HNRNPC protein in cells under genotoxic stimulus
CONCLUSIONS AND SIGNIFICANCE: Overall, DUSP3 can modulate cellular responses to genotoxic stimuli at the translational level by maintaining the stability of HNRNPC-ITAF complexes and regulating the intensity and specificity of RNA interactions with RRM-domain proteins.PMID:38538536 | DOI:10.1111/boc.202300128 (Source: Biology of the Cell)
Source: Biology of the Cell - March 27, 2024 Category: Cytology Authors: Pault Y M Ferruzo Viktor K Boell Lilian C Russo Carla C Oliveira Fabio L Forti Source Type: research
BRCA1 deficiency enhances the aggressiveness of breast cancer cells expressing HPV16 oncoproteins
CONCLUSIONS: Our results indicate that a deficiency of BRCA1 promotes the transactivation activity of HPV16E6E7 leading to increase of cell proliferation and invasion.SIGNIFICANCE: HPV infection appears to have the potential to enhance the aggressiveness of breast cancers, especially those deficient in BRCA1.PMID:38514439 | DOI:10.1111/boc.202300072 (Source: Biology of the Cell)
Source: Biology of the Cell - March 21, 2024 Category: Cytology Authors: Jariya Sangthong Chanitra Thuwajit Laran T Jensen Waraporn Komyod Jirundon Yuvaniyama Mathurose Ponglikitmongkol Source Type: research
BRCA1 deficiency enhances the aggressiveness of breast cancer cells expressing HPV16 oncoproteins
CONCLUSIONS: Our results indicate that a deficiency of BRCA1 promotes the transactivation activity of HPV16E6E7 leading to increase of cell proliferation and invasion.SIGNIFICANCE: HPV infection appears to have the potential to enhance the aggressiveness of breast cancers, especially those deficient in BRCA1.PMID:38514439 | DOI:10.1111/boc.202300072 (Source: Biology of the Cell)
Source: Biology of the Cell - March 21, 2024 Category: Cytology Authors: Jariya Sangthong Chanitra Thuwajit Laran T Jensen Waraporn Komyod Jirundon Yuvaniyama Mathurose Ponglikitmongkol Source Type: research
BRCA1 deficiency enhances the aggressiveness of breast cancer cells expressing HPV16 oncoproteins
CONCLUSIONS: Our results indicate that a deficiency of BRCA1 promotes the transactivation activity of HPV16E6E7 leading to increase of cell proliferation and invasion.SIGNIFICANCE: HPV infection appears to have the potential to enhance the aggressiveness of breast cancers, especially those deficient in BRCA1.PMID:38514439 | DOI:10.1111/boc.202300072 (Source: Biology of the Cell)
Source: Biology of the Cell - March 21, 2024 Category: Cytology Authors: Jariya Sangthong Chanitra Thuwajit Laran T Jensen Waraporn Komyod Jirundon Yuvaniyama Mathurose Ponglikitmongkol Source Type: research
BRCA1 deficiency enhances the aggressiveness of breast cancer cells expressing HPV16 oncoproteins
CONCLUSIONS: Our results indicate that a deficiency of BRCA1 promotes the transactivation activity of HPV16E6E7 leading to increase of cell proliferation and invasion.SIGNIFICANCE: HPV infection appears to have the potential to enhance the aggressiveness of breast cancers, especially those deficient in BRCA1.PMID:38514439 | DOI:10.1111/boc.202300072 (Source: Biology of the Cell)
Source: Biology of the Cell - March 21, 2024 Category: Cytology Authors: Jariya Sangthong Chanitra Thuwajit Laran T Jensen Waraporn Komyod Jirundon Yuvaniyama Mathurose Ponglikitmongkol Source Type: research
