Lactobacillus rhamnosus GG ameliorates radiation-induced lung fibrosis via lncRNASNHG17/PTBP1/NICD axis modulation
Radiation-induced pulmonary fibrosis (RIPF) is a major side effect experienced for patients with thoracic cancers after radiotherapy. RIPF is poor prognosis and limited therapeutic options available in clinic. La... (Source: Biology Direct)
Source: Biology Direct - January 12, 2023 Category: Biology Authors: Zhao Ju, Huiji Pan, Can Qu, Liang Xiao, Meiling Zhou, Yin Wang, Jinhua Luo, Liangfang Shen, Pingkun Zhou and Ruixue Huang Tags: Research Source Type: research
M2 macrophage-derived exosomal miR-193b-3p promotes progression and glutamine uptake of pancreatic cancer by targeting TRIM62
Pancreatic cancer (PC) is a highly lethal malignancy that requires effective novel therapies. M2 macrophages are abundant in the PC microenvironment and promote cancer progression. Exosomes are emerging mediat... (Source: Biology Direct)
Source: Biology Direct - January 11, 2023 Category: Biology Authors: Ke Zhang, Yu-Jie Li, Lin-Jia Peng, Hui-Feng Gao, Lu-Ming Liu and Hao Chen Tags: Research Source Type: research
LINC00858 stabilizes RAN expression and promotes metastasis of gastric cancer
Metastasis constitutes one of the major causes of tumor-related death in gastric cancer (GC), and understanding key events in the initiation of this phenotypic switch may provide therapeutic opportunities. Lon... (Source: Biology Direct)
Source: Biology Direct - December 17, 2022 Category: Biology Authors: Yunxin Lu, Qi Meng, Long Bai, Ruobing Wang, Yong Sun, Jiaqi Li, Jun Fan and Tian Tian Tags: Research Source Type: research
Alpha-actnin-4 (ACTN4) selectively affects the DNA double-strand breaks repair in non-small lung carcinoma cells
ACTN4 is an actin-binding protein involved in many cellular processes, including cancer development. High ACTN4 expression is often associated with a poor prognosis. However, it has been identified as a positi... (Source: Biology Direct)
Source: Biology Direct - December 7, 2022 Category: Biology Authors: Daria Kriger, Ksenia Novitskaya, Giomar Vasileva, Ekaterina Lomert, Nikolai D. Aksenov, Nikolai A. Barlev and Dmitri Tentler Tags: Research Source Type: research
Artificial genetic polymers against human pathologies
Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community. Due to their unique biophysical features these... (Source: Biology Direct)
Source: Biology Direct - December 6, 2022 Category: Biology Authors: Gleb S. Ivanov, Vyacheslav G. Tribulovich, Nikolay B. Pestov, Temitope I. David, Abdul-Saleem Amoah, Tatyana V. Korneenko and Nikolai A. Barlev Tags: Review Source Type: research
p53 regulates expression of nuclear envelope components in cancer cells
Nuclear organisation and architecture are essential for the maintenance of genomic integrity as well as for the epigenetic regulations and gene expression. Disruption of lamin B1, major structural and function... (Source: Biology Direct)
Source: Biology Direct - December 2, 2022 Category: Biology Authors: Emanuele Panatta, Alessio Butera, Ivana Celardo, Marcel Leist, Gerry Melino and Ivano Amelio Tags: Research Source Type: research
Expression of Synj2bp in mouse liver regulates the extent of wrappER-mitochondria contact to maintain hepatic lipid homeostasis
In mouse liver hepatocytes, nearly half of the surface area of every mitochondrion is covered by wrappER, a wrapping-type of ER that is rich in fatty acids and synthesizes lipoproteins (VLDL) (Anastasia et al.... (Source: Biology Direct)
Source: Biology Direct - December 1, 2022 Category: Biology Authors: Nicol ò Ilacqua, Irene Anastasia, Danylo Aloshyn, Rana Ghandehari-Alavijeh, Emily Ann Peluso, Madelaine C. Brearley-Sholto, Leonardo V. Pellegrini, Andrea Raimondi, Thomas Q. de Aguiar Vallim and Luca Pellegrini Tags: Research Source Type: research
Small extracellular vesicles derived from Nrf2-overexpressing human amniotic mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting NLRP3
Acute lung injury (ALI) is a major cause of respiratory failure in critically ill patients that results in significant morbidity and mortality. Recent studies indicate that cell-based therapies may be benefici... (Source: Biology Direct)
Source: Biology Direct - November 29, 2022 Category: Biology Authors: Lijuan Xu, Yunlou Zhu, Congye Li, Qixing Wang, Lijie Ma, Junjie Wang and Shouqin Zhang Tags: Research Source Type: research
Long-read assembly of major histocompatibility complex and killer cell immunoglobulin-like receptor genome regions in cynomolgus macaque
The major histocompatibility complex (MHC) and the killer cell immunoglobulin-like receptors (KIR) are key regulators of immune responses. The cynomolgus macaque, an Old World monkey species, can be applied as... (Source: Biology Direct)
Source: Biology Direct - November 29, 2022 Category: Biology Authors: Qingxiu Hu, Xiaoqi Huang, Yabin Jin, Rui Zhang, Aimin Zhao, Yiping Wang, Chenyun Zhou, Weixin Liu, Xunwei Liu, Chunhua Li, Guangyi Fan, Min Zhuo, Xiaoning Wang, Fei Ling and Wei Luo Tags: Research Source Type: research
CXCL1 promotes colon cancer progression through activation of NF- κB/P300 signaling pathway
The upregulated expression of CXCL1 has been validated in colorectal cancer patients. As a potential biotherapeutic target for colorectal cancer, the mechanism by which CXCL1 affects the development of colorec... (Source: Biology Direct)
Source: Biology Direct - November 25, 2022 Category: Biology Authors: Changhua Zhuo, Qiang Ruan, Xiangqian Zhao, Yangkun Shen and Ruirong Lin Tags: Research Source Type: research
N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway
Pancreatic cancer (PC) is highly malignant. Chemotherapy is the main treatment strategy, especially for patients with advanced PC. However, chemoresistance has always been a frequently encountered bottleneck. ... (Source: Biology Direct)
Source: Biology Direct - November 17, 2022 Category: Biology Authors: Chengjie Lin, Yan Wang, Yihong Dong, Shihui Lai, Liang Wang, Shangeng Weng and Xiang Zhang Tags: Research Source Type: research
LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis
This study aimed to investigate the role of the long... (Source: Biology Direct)
Source: Biology Direct - November 16, 2022 Category: Biology Authors: Tingwei Peng, Mingchuan Liu, Lang Hu, Dong Guo, Di Wang, Bingchao Qi, Gaotong Ren, Chenchen Hu, Feng Zhang, Hyung J. Chun, Liqiang Song, Jianqiang Hu and Yan Li Tags: Research Source Type: research
Dual-labeled nanoparticles based on small extracellular vesicles for tumor detection
Small extracellular vesicles (sEVs) are emerging natural nanoplatforms in cancer diagnosis and therapy, through the incorporation of signal components or drugs in their structure. However, for their translatio... (Source: Biology Direct)
Source: Biology Direct - November 14, 2022 Category: Biology Authors: Ana Santos-Coquillat, Desir é Herreros-Pérez, Rafael Samaniego, María Isabel González, Lorena Cussó, Manuel Desco and Beatriz Salinas Tags: Research Source Type: research
Host age structure reshapes parasite symbiosis: collaboration begets pathogens, competition begets virulent mutualists
Symbiotic relationships are ubiquitous in the biosphere. Inter-species symbiosis is impacted by intra-specific distinctions, in particular, those defined by the age structure of a population. Older individuals... (Source: Biology Direct)
Source: Biology Direct - November 12, 2022 Category: Biology Authors: Carsten O. S. Portner, Edward G. Rong, Jared A. Ramirez, Yuri I. Wolf, Angelique P. Bosse, Eugene V. Koonin and Nash D. Rochman Tags: Research Source Type: research
Identification and validation of a novel signature as a diagnostic and prognostic biomarker in colorectal cancer
Colorectal cancer (CRC) is one of the most common malignant neoplasms worldwide. Although marker genes associated with CRC have been identified previously, only a few have fulfilled the therapeutic demand. The... (Source: Biology Direct)
Source: Biology Direct - November 2, 2022 Category: Biology Authors: Di Wang, Junye Liufu, Qiyuan Yang, Shengqun Dai, Jiaqi Wang and Biao Xie Tags: Research Source Type: research
