Mammalian enabled protein enhances tamoxifen sensitivity of the hormone receptor-positive breast cancer patients by suppressing the AKT signaling pathway
Mammalian enabled (MENA) protein is a member of the enabled/vasodilator stimulated phosphoprotein (Ena/VASP) protein family, which regulates cytoplasmic actin network assembly. It plays a significant role in b... (Source: Biology Direct)
Source: Biology Direct - March 8, 2024 Category: Biology Authors: Lifang He, Chuanghong She, Sen Jiang, Zhaochang Qi, Zihao Deng, Likeng Ji, Yukun Cui and Jundong Wu Tags: Research Source Type: research
Dysregulation and antimetastatic function of circLRIG1 modulated by miR-214-3p/LRIG1 axis in bladder carcinoma
This study explored the role of circLRIG1 in the development and progression of bladder carcinoma a... (Source: Biology Direct)
Source: Biology Direct - March 7, 2024 Category: Biology Authors: Shiliang Cheng, Chunguang Li, Lu Liu, Xinli Liu, Meng Li, Jinhua Zhuo, Jue Wang, Wen Zheng and Zhongmin Wang Tags: Research Source Type: research
PHF5A promotes esophageal squamous cell carcinoma progression via stabilizing VEGFA
Esophageal squamous cell carcinoma (ESCC) is the main subtype of esophageal cancer. Current therapeutic effect is far from satisfaction. Hence, identifying susceptible genes and potential targets is necessary ... (Source: Biology Direct)
Source: Biology Direct - March 1, 2024 Category: Biology Authors: Zhiwei Chang, Yongxu Jia, Ming Gao, Lijie Song, Weijie Zhang, Ruihua Zhao, Dandan Yu, Xiaolei Liu, Jing Li and Yanru Qin Tags: Research Source Type: research
Unlocking hepatocellular carcinoma aggression: STAMBPL1-mediated TRAF2 deubiquitination activates WNT/PI3K/NF-kb signaling pathway
STAM Binding Protein Like 1 (STAMBPL1), functions as a deubiquitinase (DUB) and plays a significant role in various types of cancers. However, its effect as a DUB participating in the HCC tumorigenesis and pro... (Source: Biology Direct)
Source: Biology Direct - February 28, 2024 Category: Biology Authors: Zhihuai Wang, Yinjie Zhang, Yuhang Shen, Haiyang Zhou, Yuan Gao, Chunfu Zhu and Xihu Qin Tags: Research Source Type: research
Comprehensive analysis of mitochondria-related genes indicates that PPP2R2B is a novel biomarker and promotes the progression of bladder cancer via Wnt signaling pathway
Bladder cancer (BC) is the fourth and tenth most common malignancy in men and women worldwide, respectively. The complexity of the molecular biological mechanism behind BC is a major contributor to the lack of... (Source: Biology Direct)
Source: Biology Direct - February 26, 2024 Category: Biology Authors: Du Shen and Shaosan Kang Tags: Research Source Type: research
RARRES1 inhibits hepatocellular carcinoma progression and increases its sensitivity to lenvatinib through interaction with SPINK2
Lenvatinib is an oral small molecule inhibitor approved for treating patients with unresectable hepatocellular carcinoma (HCC) worldwide. Increasing cell sensitivity to lenvatinib would be an effective method ... (Source: Biology Direct)
Source: Biology Direct - February 23, 2024 Category: Biology Authors: Yarong Guo, Bao Chai, Hezhao Zhang, Xinhao Chai, Yan Chen, Jun Xu, Liwei Qin and Yuting Chai Tags: Research Source Type: research
RPL35A promotes the progression of cholangiocarcinoma by mediating HSPA8 ubiquitination
Cholangiocarcinoma (CCA) is a biliary epithelial malignant tumor with an increasing incidence worldwide. Therefore, further understanding of the molecular mechanisms of CCA progression is required to identify ... (Source: Biology Direct)
Source: Biology Direct - February 23, 2024 Category: Biology Authors: Chengshuo Zhang, Yu Wang, Gang Wu, Ning Sun, Han Bai, Xuejian Li, Shuai Han, Haonan Zhou, Ruizhao Qi and Jialin Zhang Tags: Research Source Type: research
Tissue-specific roles of peroxisomes revealed by expression meta-analysis
Peroxisomes are primarily studied in the brain, kidney, and liver due to the conspicuous tissue-specific pathology of peroxisomal biogenesis disorders. In contrast, little is known about the role of peroxisome... (Source: Biology Direct)
Source: Biology Direct - February 16, 2024 Category: Biology Authors: Matthias Plessner, Leonie Thiele, Julia Hofhuis and Sven Thoms Tags: Research Source Type: research
USP40 promotes hepatocellular carcinoma cell proliferation, migration and stemness by deubiquitinating and stabilizing Claudin1
Hepatocellular carcinoma (HCC) is a prevalent malignant tumor that poses a major threat to people ’s lives and health. Previous studies have found that multiple deubiquitinating enzymes are involved in the path... (Source: Biology Direct)
Source: Biology Direct - February 2, 2024 Category: Biology Authors: Qingsong Wu, Yuanyuan Qiu, Jinhui Guo, Zibo Yuan, Yingnan Yang, Qingwei Zhu, Zhe Zhang, Junwei Guo, Yanfang Wu, Junyu Zhang, Dongsheng Huang, Kangsheng Tu and Xiaoge Hu Tags: Research Source Type: research
Correction: Risk assessment of transgender people: implementation of a demasculinizing –feminizing rodent model including the evaluation of thyroid homeostasis
(Source: Biology Direct)
Source: Biology Direct - January 30, 2024 Category: Biology Authors: Alessia Tammaro, Gabriele Lori, Andrea Martinelli, Luigia Cancemi, Roberta Tassinari and Francesca Maranghi Tags: Correction Source Type: research
Effect of glycosylation on the affinity of the MTB protein Ag85B for specific antibodies: towards the design of a dual-acting vaccine against tuberculosis
To create a dual-acting vaccine that can fight against tuberculosis, we combined antigenic arabino-mannan analogues with the Ag85B protein. To start the process, we studied the impact of modifying different pa... (Source: Biology Direct)
Source: Biology Direct - January 25, 2024 Category: Biology Authors: Roberta Bernardini, Sara Tengattini, Zhihao Li, Luciano Piubelli, Teodora Bavaro, Anamaria Bianca Modolea, Maurizio Mattei, Paola Conti, Stefano Marini, Yongmin Zhang, Loredano Pollegioni, Caterina Temporini and Marco Terreni Tags: Research Source Type: research
Mir-338-3p targeting THBS1 attenuates glioma progression by inhibiting the PI3K/Akt pathway
Glioma is a brain tumor with high morbidity and mortality rates. Understanding its molecular pathogenesis can provide targets and therapeutic strategies for glioma treatment. miR-338-3p represses tumor growth ... (Source: Biology Direct)
Source: Biology Direct - January 24, 2024 Category: Biology Authors: Lianglei Jiang, Ting Fang, Tingting Hu, Jun Feng and Pengfei Yan Tags: Research Source Type: research
MiR-31-5p regulates the neuroinflammatory response via TRAF6 in neuropathic pain
Neuropathic pain is chronic pain and has few effective control strategies. Studies have demonstrated that microRNAs have functions in neuropathic pain. However, no study has been conducted to demonstrate the r... (Source: Biology Direct)
Source: Biology Direct - January 24, 2024 Category: Biology Authors: Yuqi Liu, Lijuan Wang, Chengcheng Zhou, Yuan Yuan, Bin Fang, Kaimei Lu, Fangxia Xu, Lianhua Chen and Lina Huang Tags: Research Source Type: research
PICLS with human cells is the first high throughput screening method for identifying novel compounds that extend lifespan
Gerontology research on anti-aging interventions with drugs could be an answer to age-related diseases, aiming at closing the gap between lifespan and healthspan. Here, we present two methods for assaying chro... (Source: Biology Direct)
Source: Biology Direct - January 23, 2024 Category: Biology Authors: Mohammad Alfatah, Yizhong Zhang, Arshia Naaz, Trishia Yi Ning Cheng and Frank Eisenhaber Tags: Research Source Type: research
PLAU promotes growth and attenuates cisplatin chemosensitivity in ARID1A-depleted non-small cell lung cancer through interaction with TM4SF1
Loss of ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, contributes to malignant progression in multiple cancers including non-small cell lung cancer (NSCLC). In the search for key genes mediating ... (Source: Biology Direct)
Source: Biology Direct - January 17, 2024 Category: Biology Authors: Yuanliang Zheng, Lixiang Zhang, Kangliang Zhang, Shenghao Wu, Chichao Wang, Risheng Huang and Hongli Liao Tags: Research Source Type: research
