A link between mitotic defects and mitotic catastrophe: detection and cell fate
Although the phenomenon of mitotic catastrophe was first described more than 80 years ago, only recently has this term been used to explain a mechanism of cell death linked to delayed mitosis. Several mechanis... (Source: Biology Direct)
Source: Biology Direct - December 9, 2021 Category: Biology Authors: Elena V. Sazonova, Svetlana V. Petrichuk, Gelina S. Kopeina and Boris Zhivotovsky Tags: Review Source Type: research
Study on the mechanism of LOXL1-AS1/miR-3614-5p/YY1 signal axis in the malignant phenotype regulation of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with high mortality worldwide. Accumulating researches have indicated that long non ‑coding RNAs (lncRNAs) are involved in varies human ... (Source: Biology Direct)
Source: Biology Direct - December 4, 2021 Category: Biology Authors: ZhenYu Feng, ZhenYu Ye, JiaMing Xie, Wei Chen, Wei Li and ChunGen Xing Tags: Research Source Type: research
The p53 family member p73 in the regulation of cell stress response
During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue homeostasis and resulting in subsequent hyperplasia. This process is paralleled by resumption of cell cycle, aberrant D... (Source: Biology Direct)
Source: Biology Direct - November 8, 2021 Category: Biology Authors: Julian M. Rozenberg, Svetlana Zvereva, Aleksandra Dalina, Igor Blatov, Ilya Zubarev, Daniil Luppov, Alexander Bessmertnyi, Alexander Romanishin, Lamak Alsoulaiman, Vadim Kumeiko, Alexander Kagansky, Gerry Melino, Carlo Ganini and Nikolai A. Barlev Tags: Review Source Type: research
Rab32 uses its effector reticulon 3L to trigger autophagic degradation of mitochondria-associated membrane (MAM) proteins
Rab32 is a small GTPase associated with multiple organelles but is particularly enriched at the endoplasmic reticulum (ER). Here, it controls targeting to mitochondria-ER contacts (MERCs), thus influencing com... (Source: Biology Direct)
Source: Biology Direct - November 7, 2021 Category: Biology Authors: Maria Sol Herrera-Cruz, Megan C. Yap, Nasser Tahbaz, Keelie Phillips, Laurel Thomas, Gary Thomas and Thomas Simmen Tags: Research Source Type: research
Transcription factor KLF15 inhibits the proliferation and migration of gastric cancer cells via regulating the TFAP2A-AS1/NISCH axis
Recently, overwhelming evidence supports that long noncoding RNAs (lncRNAs) play crucial roles in the occurrence and progression of tumors. However, the role and mechanism of lncRNA TFAP2A-AS1 in human gastric... (Source: Biology Direct)
Source: Biology Direct - November 3, 2021 Category: Biology Authors: Xin Zhao, Linlin Chen, Jingxun Wu, Jun You, Qingqi Hong and Feng Ye Tags: Research Source Type: research
Principles and biological concepts of heredity before Mendel
The knowledge of the history of a subject stimulates understanding. As we study how other people have made scientific breakthroughs, we develop the breadth of imagination that would inspire us to make new disc... (Source: Biology Direct)
Source: Biology Direct - October 21, 2021 Category: Biology Authors: P éter Poczai and Jorge A. Santiago-Blay Tags: Review Source Type: research
Micronucleus production, activation of DNA damage response and cGAS-STING signaling in syncytia induced by SARS-CoV-2 infection
SARS-CoV-2 infection could cause severe acute respiratory syndrome, largely attributed to dysregulated immune activation and extensive lung tissue damage. However, the underlying mechanisms are not fully under... (Source: Biology Direct)
Source: Biology Direct - October 21, 2021 Category: Biology Authors: He Ren, Chaobing Ma, Haoran Peng, Bo Zhang, Lulin Zhou, Yan Su, Xiaoyan Gao and Hongyan Huang Tags: Research Source Type: research
Redressing the interactions between stem cells and immune system in tissue regeneration
Skeletal muscle has an extraordinary regenerative capacity reflecting the rapid activation and effective differentiation of muscle stem cells (MuSCs). In the course of muscle regeneration, MuSCs are reprogramm... (Source: Biology Direct)
Source: Biology Direct - October 20, 2021 Category: Biology Authors: Jiankai Fang, Chao Feng, Wangwang Chen, Pengbo Hou, Zhanhong Liu, Muqiu Zuo, Yuyi Han, Chenchang Xu, Gerry Melino, Alexei Verkhratsky, Ying Wang, Changshun Shao and Yufang Shi Tags: Review Source Type: research
The periosteum: a simple tissue with many faces, with special reference to the antler-lineage periostea
Periosteum is a thin membrane covering bone surfaces and consists of two layers: outer fibrous layer and inner cambium layer. Simple appearance of periosteum has belied its own complexity as a composite struct... (Source: Biology Direct)
Source: Biology Direct - October 18, 2021 Category: Biology Authors: Chunyi Li and Peter Fennessy Tags: Review Source Type: research
Circ_0067680 expedites the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells through miR-4429/CTNNB1/Wnt/ β-catenin pathway
Human bone marrow-derived mesenchymal stem cells (hBMSCs) are the primary source of osteoblasts in vivo. Emerging literatures have unveiled that circular RNAs (circRNAs) are actively drawn in the osteogenic di... (Source: Biology Direct)
Source: Biology Direct - October 14, 2021 Category: Biology Authors: Yuansheng Huang, Su Wan and Min Yang Tags: Research Source Type: research
Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer
The interaction between proteins is a fundamental event for cellular life that is generally mediated by specialized protein domains or modules. PDZ domains are the largest class of protein –protein interaction ... (Source: Biology Direct)
Source: Biology Direct - October 12, 2021 Category: Biology Authors: Caterina Nardella, Lorenzo Visconti, Francesca Malagrin ò, Livia Pagano, Marianna Bufano, Marianna Nalli, Antonio Coluccia, Giuseppe La Regina, Romano Silvestri, Stefano Gianni and Angelo Toto Tags: Review Source Type: research
Long non-coding RNA SNHG8 enhances triple-negative breast cancer cell proliferation and migration by regulating the miR-335-5p/PYGO2 axis
Growing evidence has demonstrated that long non-coding RNAs (lncRNAs) can function as modulators in the development of triple-negative breast cancer (TNBC). However, the function of lncRNA small nucleolar RNA ... (Source: Biology Direct)
Source: Biology Direct - August 6, 2021 Category: Biology Authors: Jintao Qian, Xinhan Lei, Yue Sun, Lu Zheng, Jia Li, Shuai Zhang, Lei Zhang, Wanwan Li, Jianing Shi, Wenjun Jia and Tong Tang Tags: Research Source Type: research
Understanding p53 tumour suppressor network
The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulation of several cellular functions, including cell cycle progression and cell death in response to genotoxic st... (Source: Biology Direct)
Source: Biology Direct - August 6, 2021 Category: Biology Authors: Emanuele Panatta, Carlotta Zampieri, Gerry Melino and Ivano Amelio Tags: Opinion Source Type: research
Lifestyle-dependent microglial plasticity: training the brain guardians
Lifestyle is one of the most powerful instruments shaping mankind; the lifestyle includes many aspects of interactions with the environment, from nourishment and education to physical activity and quality of s... (Source: Biology Direct)
Source: Biology Direct - August 5, 2021 Category: Biology Authors: Marcus Augusto-Oliveira and Alexei Verkhratsky Tags: Review Source Type: research
NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network
Most inactivating mutations in TP53 gene generates neomorphic forms of p53 proteins that experimental evidence and clinical observations suggest to exert gain-of-function effects. While massive effort has been... (Source: Biology Direct)
Source: Biology Direct - August 4, 2021 Category: Biology Authors: Eleonora Mammarella, Carlotta Zampieri, Emanuele Panatta, Gerry Melino and Ivano Amelio Tags: Research Source Type: research
