Bioinformatics and Biology Insights This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

SARS-CoV-2 Spike Protein Mutations in Different Variants: A Comparison Between Vaccinated and Unvaccinated Population in Western Amazonia
In conclusion, the study showed a temporal increase in mutations and subvariants for characterized strains. Furthermore, the vaccination profile did not impact significant changes in the mutational profile yet remains a determining factor for severe disease.PMID:37461740 | PMC:PMC10350575 | DOI:10.1177/11779322231186477 (Source: Bioinformatics and Biology Insights)
Source: Bioinformatics and Biology Insights - July 18, 2023 Category: Bioinformatics Authors: Gabriella Sgorlon T árcio Peixoto Roca Ana Maisa Passos-Silva M árlon Grégori Flores Custódio Jackson Alves da Silva Queiroz Andr é Luiz Ferreira da Silva Karolaine Santos Teixeira Fl ávia Serrano Batista Juan Miguel Villalobos Salcedo Rita de Cassi Source Type: research

Molecular Biomarker Identification Using a Network-Based Bioinformatics Approach That Links COVID-19 With Smoking
Bioinform Biol Insights. 2023 Jul 14;17:11779322231186481. doi: 10.1177/11779322231186481. eCollection 2023.ABSTRACTThe COVID-19 coronavirus, which primarily affects the lungs, is the source of the disease known as SARS-CoV-2. According to "Smoking and COVID-19: a scoping review," about 32% of smokers had a severe case of COVID-19 pneumonia at their admission time and 15% of non-smokers had this case of COVID-19 pneumonia. We were able to determine which genes were expressed differently in each group by comparing the expression of gene transcriptomic datasets of COVID-19 patients, smokers, and healthy controls. In all, 37 ...
Source: Bioinformatics and Biology Insights - July 18, 2023 Category: Bioinformatics Authors: Md Anisur Rahman Md Al Amin Most Nilufa Yeasmin Md Zahidul Islam Source Type: research

Metagenomics Reveals the Microbiome Multifunctionalities of Environmental Importance From Termite Mound Soils
This study reveals opportunities to revisit the multifunctionalities of termite mound soils in order to establish a connection between taxonomic diversity, targeted functions, and genes that could improve plant yield and health in unfavorable soil conditions.PMID:37424707 | PMC:PMC10328015 | DOI:10.1177/11779322231184025 (Source: Bioinformatics and Biology Insights)
Source: Bioinformatics and Biology Insights - July 10, 2023 Category: Bioinformatics Authors: Ben Jesuorsemwen Enagbonma Olubukola Oluranti Babalola Source Type: research

A Novel Inhibitor of DKK1/LRP6 Interactions Against the Alzheimer Disease: An Insilco Approach
Bioinform Biol Insights. 2023 Jun 28;17:11779322231183762. doi: 10.1177/11779322231183762. eCollection 2023.ABSTRACTThe activation of the Wnt signaling pathway is implicated in a neuroprotective mechanism against the Alzheimer disease. When this pathway is blocked, it activates GSK3 beta, leading to tau hyperphosphorylation and the apoptosis of neurons. Dickkopf-related protein 1 (DKK1) is a protein that competes with the Wnt ligand for the low-density lipoprotein receptor-related protein 6 (LRP6) receptor's binding, interrupting the Wnt-induced Fzd-Wnt-LRP6 complex. This counteracts Wnt's neuroprotective effect and contri...
Source: Bioinformatics and Biology Insights - July 10, 2023 Category: Bioinformatics Authors: Manisha Prajapat Harvinder Singh Gajendra Chaudhary Phulen Sarma Gurjeet Kaur Ajay Prakash Patel Bikash Medhi Source Type: research

In Silico Functional Characterization of a Hypothetical Protein From < em > Pasteurella Multocida < /em > Reveals a Novel < em > S < /em > -Adenosylmethionine-Dependent Methyltransferase Activity
Bioinform Biol Insights. 2023 Jul 3;17:11779322231184024. doi: 10.1177/11779322231184024. eCollection 2023.ABSTRACTGenomes may now be sequenced in a matter of weeks, leading to an influx of "hypothetical" proteins (HP) whose activities remain a mystery in GenBank. The information included inside these genes has quickly grown in prominence. Thus, we selected to look closely at the structure and function of an HP (AFF25514.1; 246 residues) from Pasteurella multocida (PM) subsp. multocida str. HN06. Possible insights into bacterial adaptation to new environments and metabolic changes might be gained by studying the functions ...
Source: Bioinformatics and Biology Insights - July 10, 2023 Category: Bioinformatics Authors: Md Habib Ullah Masum Sultana Rajia Uditi Paul Bristi Mir Salma Akter Mohammad Ruhul Amin Tushar Ahmed Shishir Jannatul Ferdous Firoz Ahmed Md Mizanur Rahaman Otun Saha Source Type: research