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In Silico Analysis of the Dextransucrase Obtained From < em > Leuconostoc mesenteroides < /em > Strain IBUN 91.2.98
Bioinform Biol Insights. 2023 Nov 28;17:11779322231212751. doi: 10.1177/11779322231212751. eCollection 2023.ABSTRACTThe DSR-IBUN dextransucrase produced by Leuconostoc mesenteroides strain IBUN 91.2.98 has a short production time (4.5 hours), an enzymatic activity of 24.8 U/mL, and a specific activity of purified enzyme 2 times higher (331.6 U/mg) than that reported for similar enzymes. The aim of this study was to generate a structural model that, from an in silico approach, allows a better understanding, from the structural point of view, of the activity obtained by the enzyme of interest, which is key to continue with i...
Source: Bioinformatics and Biology Insights - November 30, 2023 Category: Bioinformatics Authors: Luisa Alejandra Garc ía Galindo Martha Margarita Gonz ález Jairo Alonso Cer ón Salamanca Sonia Amparo Ospina S ánchez Source Type: research

A Systems Biology Approach for Investigating Significant Biomarkers and Drug Targets Common Among Patients with Gonorrhea, Chlamydia, and Prostate Cancer: A Pilot Study
In this study, we studied RNA-seq gene expression profiles using computational biology methods to find out potential biomarkers that could help us in understanding the patho-biological mechanisms of gonorrhea, chlamydia, and prostate cancer. Using statistical methods on the Gene Expression Omnibus (GEO) data sets, it was found that a total of 22 distinct differentially expressed genes were shared among these 3 diseases of which 14 were up-regulated (PGRMC1, TSC22D1, SH3BGRL, NNT, CTSC, FRMD3, CCR2, FAM210B, VCL, PTGS1, SLFN11, SLC40A1, PROS1, and DSE) and the remaining 8 genes were down-regulated (PRNP, HINT3, MARCKSL1, TM...
Source: Bioinformatics and Biology Insights - November 30, 2023 Category: Bioinformatics Authors: Abdulla Al Noman Md Kobirul Islam Tasmiah Feroz Md Monir Hossain Md Shahariar Kabir Shakil Source Type: research

A Comprehensive Bioinformatics Approach to Identify Molecular Signatures and Key Pathways for the Huntington Disease
This study combined bioinformatics analysis and network-based system biology approaches to discover the biomarker, pathways, and drug targets related to molecular mechanism of HD etiology. The gene expression profile data sets GSE64810 and GSE95343 were analyzed to predict the molecular markers in HD where 162 mutual differentially expressed genes (DEGs) were detected. Ten hub genes among them (DUSP1, NKX2-5, GLI1, KLF4, SCNN1B, NPHS1, SGK2, PITX2, S100A4, and MSX1) were identified from protein-protein interaction (PPI) network which were mostly expressed as down-regulated. Following that, transcription factors (TFs)-DEGs ...
Source: Bioinformatics and Biology Insights - November 30, 2023 Category: Bioinformatics Authors: Tahera Mahnaz Meem Umama Khan Md Bazlur Rahman Mredul Md Abdul Awal Md Habibur Rahman Md Salauddin Khan Source Type: research

In Silico Analysis of the Dextransucrase Obtained From < em > Leuconostoc mesenteroides < /em > Strain IBUN 91.2.98
Bioinform Biol Insights. 2023 Nov 28;17:11779322231212751. doi: 10.1177/11779322231212751. eCollection 2023.ABSTRACTThe DSR-IBUN dextransucrase produced by Leuconostoc mesenteroides strain IBUN 91.2.98 has a short production time (4.5 hours), an enzymatic activity of 24.8 U/mL, and a specific activity of purified enzyme 2 times higher (331.6 U/mg) than that reported for similar enzymes. The aim of this study was to generate a structural model that, from an in silico approach, allows a better understanding, from the structural point of view, of the activity obtained by the enzyme of interest, which is key to continue with i...
Source: Bioinformatics and Biology Insights - November 30, 2023 Category: Bioinformatics Authors: Luisa Alejandra Garc ía Galindo Martha Margarita Gonz ález Jairo Alonso Cer ón Salamanca Sonia Amparo Ospina S ánchez Source Type: research

A Systems Biology Approach for Investigating Significant Biomarkers and Drug Targets Common Among Patients with Gonorrhea, Chlamydia, and Prostate Cancer: A Pilot Study
In this study, we studied RNA-seq gene expression profiles using computational biology methods to find out potential biomarkers that could help us in understanding the patho-biological mechanisms of gonorrhea, chlamydia, and prostate cancer. Using statistical methods on the Gene Expression Omnibus (GEO) data sets, it was found that a total of 22 distinct differentially expressed genes were shared among these 3 diseases of which 14 were up-regulated (PGRMC1, TSC22D1, SH3BGRL, NNT, CTSC, FRMD3, CCR2, FAM210B, VCL, PTGS1, SLFN11, SLC40A1, PROS1, and DSE) and the remaining 8 genes were down-regulated (PRNP, HINT3, MARCKSL1, TM...
Source: Bioinformatics and Biology Insights - November 30, 2023 Category: Bioinformatics Authors: Abdulla Al Noman Md Kobirul Islam Tasmiah Feroz Md Monir Hossain Md Shahariar Kabir Shakil Source Type: research

A Comprehensive Bioinformatics Approach to Identify Molecular Signatures and Key Pathways for the Huntington Disease
This study combined bioinformatics analysis and network-based system biology approaches to discover the biomarker, pathways, and drug targets related to molecular mechanism of HD etiology. The gene expression profile data sets GSE64810 and GSE95343 were analyzed to predict the molecular markers in HD where 162 mutual differentially expressed genes (DEGs) were detected. Ten hub genes among them (DUSP1, NKX2-5, GLI1, KLF4, SCNN1B, NPHS1, SGK2, PITX2, S100A4, and MSX1) were identified from protein-protein interaction (PPI) network which were mostly expressed as down-regulated. Following that, transcription factors (TFs)-DEGs ...
Source: Bioinformatics and Biology Insights - November 30, 2023 Category: Bioinformatics Authors: Tahera Mahnaz Meem Umama Khan Md Bazlur Rahman Mredul Md Abdul Awal Md Habibur Rahman Md Salauddin Khan Source Type: research

In Silico Analysis of the Dextransucrase Obtained From < em > Leuconostoc mesenteroides < /em > Strain IBUN 91.2.98
Bioinform Biol Insights. 2023 Nov 28;17:11779322231212751. doi: 10.1177/11779322231212751. eCollection 2023.ABSTRACTThe DSR-IBUN dextransucrase produced by Leuconostoc mesenteroides strain IBUN 91.2.98 has a short production time (4.5 hours), an enzymatic activity of 24.8 U/mL, and a specific activity of purified enzyme 2 times higher (331.6 U/mg) than that reported for similar enzymes. The aim of this study was to generate a structural model that, from an in silico approach, allows a better understanding, from the structural point of view, of the activity obtained by the enzyme of interest, which is key to continue with i...
Source: Bioinformatics and Biology Insights - November 30, 2023 Category: Bioinformatics Authors: Luisa Alejandra Garc ía Galindo Martha Margarita Gonz ález Jairo Alonso Cer ón Salamanca Sonia Amparo Ospina S ánchez Source Type: research

A Systems Biology Approach for Investigating Significant Biomarkers and Drug Targets Common Among Patients with Gonorrhea, Chlamydia, and Prostate Cancer: A Pilot Study
In this study, we studied RNA-seq gene expression profiles using computational biology methods to find out potential biomarkers that could help us in understanding the patho-biological mechanisms of gonorrhea, chlamydia, and prostate cancer. Using statistical methods on the Gene Expression Omnibus (GEO) data sets, it was found that a total of 22 distinct differentially expressed genes were shared among these 3 diseases of which 14 were up-regulated (PGRMC1, TSC22D1, SH3BGRL, NNT, CTSC, FRMD3, CCR2, FAM210B, VCL, PTGS1, SLFN11, SLC40A1, PROS1, and DSE) and the remaining 8 genes were down-regulated (PRNP, HINT3, MARCKSL1, TM...
Source: Bioinformatics and Biology Insights - November 30, 2023 Category: Bioinformatics Authors: Abdulla Al Noman Md Kobirul Islam Tasmiah Feroz Md Monir Hossain Md Shahariar Kabir Shakil Source Type: research

A Comprehensive Bioinformatics Approach to Identify Molecular Signatures and Key Pathways for the Huntington Disease
This study combined bioinformatics analysis and network-based system biology approaches to discover the biomarker, pathways, and drug targets related to molecular mechanism of HD etiology. The gene expression profile data sets GSE64810 and GSE95343 were analyzed to predict the molecular markers in HD where 162 mutual differentially expressed genes (DEGs) were detected. Ten hub genes among them (DUSP1, NKX2-5, GLI1, KLF4, SCNN1B, NPHS1, SGK2, PITX2, S100A4, and MSX1) were identified from protein-protein interaction (PPI) network which were mostly expressed as down-regulated. Following that, transcription factors (TFs)-DEGs ...
Source: Bioinformatics and Biology Insights - November 30, 2023 Category: Bioinformatics Authors: Tahera Mahnaz Meem Umama Khan Md Bazlur Rahman Mredul Md Abdul Awal Md Habibur Rahman Md Salauddin Khan Source Type: research

In Silico Analysis of the Dextransucrase Obtained From < em > Leuconostoc mesenteroides < /em > Strain IBUN 91.2.98
Bioinform Biol Insights. 2023 Nov 28;17:11779322231212751. doi: 10.1177/11779322231212751. eCollection 2023.ABSTRACTThe DSR-IBUN dextransucrase produced by Leuconostoc mesenteroides strain IBUN 91.2.98 has a short production time (4.5 hours), an enzymatic activity of 24.8 U/mL, and a specific activity of purified enzyme 2 times higher (331.6 U/mg) than that reported for similar enzymes. The aim of this study was to generate a structural model that, from an in silico approach, allows a better understanding, from the structural point of view, of the activity obtained by the enzyme of interest, which is key to continue with i...
Source: Bioinformatics and Biology Insights - November 30, 2023 Category: Bioinformatics Authors: Luisa Alejandra Garc ía Galindo Martha Margarita Gonz ález Jairo Alonso Cer ón Salamanca Sonia Amparo Ospina S ánchez Source Type: research

A Systems Biology Approach for Investigating Significant Biomarkers and Drug Targets Common Among Patients with Gonorrhea, Chlamydia, and Prostate Cancer: A Pilot Study
In this study, we studied RNA-seq gene expression profiles using computational biology methods to find out potential biomarkers that could help us in understanding the patho-biological mechanisms of gonorrhea, chlamydia, and prostate cancer. Using statistical methods on the Gene Expression Omnibus (GEO) data sets, it was found that a total of 22 distinct differentially expressed genes were shared among these 3 diseases of which 14 were up-regulated (PGRMC1, TSC22D1, SH3BGRL, NNT, CTSC, FRMD3, CCR2, FAM210B, VCL, PTGS1, SLFN11, SLC40A1, PROS1, and DSE) and the remaining 8 genes were down-regulated (PRNP, HINT3, MARCKSL1, TM...
Source: Bioinformatics and Biology Insights - November 30, 2023 Category: Bioinformatics Authors: Abdulla Al Noman Md Kobirul Islam Tasmiah Feroz Md Monir Hossain Md Shahariar Kabir Shakil Source Type: research

A Comprehensive Bioinformatics Approach to Identify Molecular Signatures and Key Pathways for the Huntington Disease
This study combined bioinformatics analysis and network-based system biology approaches to discover the biomarker, pathways, and drug targets related to molecular mechanism of HD etiology. The gene expression profile data sets GSE64810 and GSE95343 were analyzed to predict the molecular markers in HD where 162 mutual differentially expressed genes (DEGs) were detected. Ten hub genes among them (DUSP1, NKX2-5, GLI1, KLF4, SCNN1B, NPHS1, SGK2, PITX2, S100A4, and MSX1) were identified from protein-protein interaction (PPI) network which were mostly expressed as down-regulated. Following that, transcription factors (TFs)-DEGs ...
Source: Bioinformatics and Biology Insights - November 30, 2023 Category: Bioinformatics Authors: Tahera Mahnaz Meem Umama Khan Md Bazlur Rahman Mredul Md Abdul Awal Md Habibur Rahman Md Salauddin Khan Source Type: research

In Silico Analysis of the Dextransucrase Obtained From < em > Leuconostoc mesenteroides < /em > Strain IBUN 91.2.98
Bioinform Biol Insights. 2023 Nov 28;17:11779322231212751. doi: 10.1177/11779322231212751. eCollection 2023.ABSTRACTThe DSR-IBUN dextransucrase produced by Leuconostoc mesenteroides strain IBUN 91.2.98 has a short production time (4.5 hours), an enzymatic activity of 24.8 U/mL, and a specific activity of purified enzyme 2 times higher (331.6 U/mg) than that reported for similar enzymes. The aim of this study was to generate a structural model that, from an in silico approach, allows a better understanding, from the structural point of view, of the activity obtained by the enzyme of interest, which is key to continue with i...
Source: Bioinformatics and Biology Insights - November 30, 2023 Category: Bioinformatics Authors: Luisa Alejandra Garc ía Galindo Martha Margarita Gonz ález Jairo Alonso Cer ón Salamanca Sonia Amparo Ospina S ánchez Source Type: research

A Systems Biology Approach for Investigating Significant Biomarkers and Drug Targets Common Among Patients with Gonorrhea, Chlamydia, and Prostate Cancer: A Pilot Study
In this study, we studied RNA-seq gene expression profiles using computational biology methods to find out potential biomarkers that could help us in understanding the patho-biological mechanisms of gonorrhea, chlamydia, and prostate cancer. Using statistical methods on the Gene Expression Omnibus (GEO) data sets, it was found that a total of 22 distinct differentially expressed genes were shared among these 3 diseases of which 14 were up-regulated (PGRMC1, TSC22D1, SH3BGRL, NNT, CTSC, FRMD3, CCR2, FAM210B, VCL, PTGS1, SLFN11, SLC40A1, PROS1, and DSE) and the remaining 8 genes were down-regulated (PRNP, HINT3, MARCKSL1, TM...
Source: Bioinformatics and Biology Insights - November 30, 2023 Category: Bioinformatics Authors: Abdulla Al Noman Md Kobirul Islam Tasmiah Feroz Md Monir Hossain Md Shahariar Kabir Shakil Source Type: research

A Comprehensive Bioinformatics Approach to Identify Molecular Signatures and Key Pathways for the Huntington Disease
This study combined bioinformatics analysis and network-based system biology approaches to discover the biomarker, pathways, and drug targets related to molecular mechanism of HD etiology. The gene expression profile data sets GSE64810 and GSE95343 were analyzed to predict the molecular markers in HD where 162 mutual differentially expressed genes (DEGs) were detected. Ten hub genes among them (DUSP1, NKX2-5, GLI1, KLF4, SCNN1B, NPHS1, SGK2, PITX2, S100A4, and MSX1) were identified from protein-protein interaction (PPI) network which were mostly expressed as down-regulated. Following that, transcription factors (TFs)-DEGs ...
Source: Bioinformatics and Biology Insights - November 30, 2023 Category: Bioinformatics Authors: Tahera Mahnaz Meem Umama Khan Md Bazlur Rahman Mredul Md Abdul Awal Md Habibur Rahman Md Salauddin Khan Source Type: research