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Effectiveness of Narciclasine in Suppressing the Inflammatory Response in Sepsis: Molecular Docking and In Silico Studies
Bioinform Biol Insights. 2024 Mar 16;18:11779322241233436. doi: 10.1177/11779322241233436. eCollection 2024.ABSTRACTNarciclasine is an alkaloid belonging to the Amaryllidaceae family which has been reported to have many beneficial properties. Especially its anticancer properties have been widely reported. Here, we have focused on its potential use in suppressing the inflammatory response in sepsis using in silico methods. Lipopolysaccharide (LPS) is an endotoxin which is present in the outer membrane of gram-negative bacteria and is a crucial player in the pathogenesis of gram-negative sepsis. Activation of toll-like recep...
Source: Bioinformatics and Biology Insights - March 18, 2024 Category: Bioinformatics Authors: Manoj Kumar Kingsley Gurugubelli Krishna Rao Ballambattu Vishnu Bhat Source Type: research

Effectiveness of Narciclasine in Suppressing the Inflammatory Response in Sepsis: Molecular Docking and In Silico Studies
Bioinform Biol Insights. 2024 Mar 16;18:11779322241233436. doi: 10.1177/11779322241233436. eCollection 2024.ABSTRACTNarciclasine is an alkaloid belonging to the Amaryllidaceae family which has been reported to have many beneficial properties. Especially its anticancer properties have been widely reported. Here, we have focused on its potential use in suppressing the inflammatory response in sepsis using in silico methods. Lipopolysaccharide (LPS) is an endotoxin which is present in the outer membrane of gram-negative bacteria and is a crucial player in the pathogenesis of gram-negative sepsis. Activation of toll-like recep...
Source: Bioinformatics and Biology Insights - March 18, 2024 Category: Bioinformatics Authors: Manoj Kumar Kingsley Gurugubelli Krishna Rao Ballambattu Vishnu Bhat Source Type: research

Effectiveness of Narciclasine in Suppressing the Inflammatory Response in Sepsis: Molecular Docking and In Silico Studies
Bioinform Biol Insights. 2024 Mar 16;18:11779322241233436. doi: 10.1177/11779322241233436. eCollection 2024.ABSTRACTNarciclasine is an alkaloid belonging to the Amaryllidaceae family which has been reported to have many beneficial properties. Especially its anticancer properties have been widely reported. Here, we have focused on its potential use in suppressing the inflammatory response in sepsis using in silico methods. Lipopolysaccharide (LPS) is an endotoxin which is present in the outer membrane of gram-negative bacteria and is a crucial player in the pathogenesis of gram-negative sepsis. Activation of toll-like recep...
Source: Bioinformatics and Biology Insights - March 18, 2024 Category: Bioinformatics Authors: Manoj Kumar Kingsley Gurugubelli Krishna Rao Ballambattu Vishnu Bhat Source Type: research

Effectiveness of Narciclasine in Suppressing the Inflammatory Response in Sepsis: Molecular Docking and In Silico Studies
Bioinform Biol Insights. 2024 Mar 16;18:11779322241233436. doi: 10.1177/11779322241233436. eCollection 2024.ABSTRACTNarciclasine is an alkaloid belonging to the Amaryllidaceae family which has been reported to have many beneficial properties. Especially its anticancer properties have been widely reported. Here, we have focused on its potential use in suppressing the inflammatory response in sepsis using in silico methods. Lipopolysaccharide (LPS) is an endotoxin which is present in the outer membrane of gram-negative bacteria and is a crucial player in the pathogenesis of gram-negative sepsis. Activation of toll-like recep...
Source: Bioinformatics and Biology Insights - March 18, 2024 Category: Bioinformatics Authors: Manoj Kumar Kingsley Gurugubelli Krishna Rao Ballambattu Vishnu Bhat Source Type: research

Effectiveness of Narciclasine in Suppressing the Inflammatory Response in Sepsis: Molecular Docking and In Silico Studies
Bioinform Biol Insights. 2024 Mar 16;18:11779322241233436. doi: 10.1177/11779322241233436. eCollection 2024.ABSTRACTNarciclasine is an alkaloid belonging to the Amaryllidaceae family which has been reported to have many beneficial properties. Especially its anticancer properties have been widely reported. Here, we have focused on its potential use in suppressing the inflammatory response in sepsis using in silico methods. Lipopolysaccharide (LPS) is an endotoxin which is present in the outer membrane of gram-negative bacteria and is a crucial player in the pathogenesis of gram-negative sepsis. Activation of toll-like recep...
Source: Bioinformatics and Biology Insights - March 18, 2024 Category: Bioinformatics Authors: Manoj Kumar Kingsley Gurugubelli Krishna Rao Ballambattu Vishnu Bhat Source Type: research

Effectiveness of Narciclasine in Suppressing the Inflammatory Response in Sepsis: Molecular Docking and In Silico Studies
Bioinform Biol Insights. 2024 Mar 16;18:11779322241233436. doi: 10.1177/11779322241233436. eCollection 2024.ABSTRACTNarciclasine is an alkaloid belonging to the Amaryllidaceae family which has been reported to have many beneficial properties. Especially its anticancer properties have been widely reported. Here, we have focused on its potential use in suppressing the inflammatory response in sepsis using in silico methods. Lipopolysaccharide (LPS) is an endotoxin which is present in the outer membrane of gram-negative bacteria and is a crucial player in the pathogenesis of gram-negative sepsis. Activation of toll-like recep...
Source: Bioinformatics and Biology Insights - March 18, 2024 Category: Bioinformatics Authors: Manoj Kumar Kingsley Gurugubelli Krishna Rao Ballambattu Vishnu Bhat Source Type: research

Effectiveness of Narciclasine in Suppressing the Inflammatory Response in Sepsis: Molecular Docking and In Silico Studies
Bioinform Biol Insights. 2024 Mar 16;18:11779322241233436. doi: 10.1177/11779322241233436. eCollection 2024.ABSTRACTNarciclasine is an alkaloid belonging to the Amaryllidaceae family which has been reported to have many beneficial properties. Especially its anticancer properties have been widely reported. Here, we have focused on its potential use in suppressing the inflammatory response in sepsis using in silico methods. Lipopolysaccharide (LPS) is an endotoxin which is present in the outer membrane of gram-negative bacteria and is a crucial player in the pathogenesis of gram-negative sepsis. Activation of toll-like recep...
Source: Bioinformatics and Biology Insights - March 18, 2024 Category: Bioinformatics Authors: Manoj Kumar Kingsley Gurugubelli Krishna Rao Ballambattu Vishnu Bhat Source Type: research

Drought Stress Amelioration Attributes of Plant-Associated Microbiome on Agricultural Plants
This article reviews the role of genome editing (GE) technologies such as CRISPR 9 (CRISPR-Cas9) related spaces and short palindromic relapse between proteins in reducing the effects of phytohormones, osmolytes, external compounds, proteins, microbes (plant growth-promoting microorganism [PGPM]), approach omics, and drought on plants that support plant growth. This research is to examine the potential of using the microbiome associated with plants for drought resistance and sustainable agriculture. Researchers also advocate using a mix of biotechnology, agronomic, and advanced GE technologies to create drought-tolerant pla...
Source: Bioinformatics and Biology Insights - March 11, 2024 Category: Bioinformatics Authors: Victor Funso Agunbiade Olubukola Oluranti Babalola Source Type: research

Drought Stress Amelioration Attributes of Plant-Associated Microbiome on Agricultural Plants
This article reviews the role of genome editing (GE) technologies such as CRISPR 9 (CRISPR-Cas9) related spaces and short palindromic relapse between proteins in reducing the effects of phytohormones, osmolytes, external compounds, proteins, microbes (plant growth-promoting microorganism [PGPM]), approach omics, and drought on plants that support plant growth. This research is to examine the potential of using the microbiome associated with plants for drought resistance and sustainable agriculture. Researchers also advocate using a mix of biotechnology, agronomic, and advanced GE technologies to create drought-tolerant pla...
Source: Bioinformatics and Biology Insights - March 11, 2024 Category: Bioinformatics Authors: Victor Funso Agunbiade Olubukola Oluranti Babalola Source Type: research

Drought Stress Amelioration Attributes of Plant-Associated Microbiome on Agricultural Plants
This article reviews the role of genome editing (GE) technologies such as CRISPR 9 (CRISPR-Cas9) related spaces and short palindromic relapse between proteins in reducing the effects of phytohormones, osmolytes, external compounds, proteins, microbes (plant growth-promoting microorganism [PGPM]), approach omics, and drought on plants that support plant growth. This research is to examine the potential of using the microbiome associated with plants for drought resistance and sustainable agriculture. Researchers also advocate using a mix of biotechnology, agronomic, and advanced GE technologies to create drought-tolerant pla...
Source: Bioinformatics and Biology Insights - March 11, 2024 Category: Bioinformatics Authors: Victor Funso Agunbiade Olubukola Oluranti Babalola Source Type: research

Drought Stress Amelioration Attributes of Plant-Associated Microbiome on Agricultural Plants
This article reviews the role of genome editing (GE) technologies such as CRISPR 9 (CRISPR-Cas9) related spaces and short palindromic relapse between proteins in reducing the effects of phytohormones, osmolytes, external compounds, proteins, microbes (plant growth-promoting microorganism [PGPM]), approach omics, and drought on plants that support plant growth. This research is to examine the potential of using the microbiome associated with plants for drought resistance and sustainable agriculture. Researchers also advocate using a mix of biotechnology, agronomic, and advanced GE technologies to create drought-tolerant pla...
Source: Bioinformatics and Biology Insights - March 11, 2024 Category: Bioinformatics Authors: Victor Funso Agunbiade Olubukola Oluranti Babalola Source Type: research

Drought Stress Amelioration Attributes of Plant-Associated Microbiome on Agricultural Plants
This article reviews the role of genome editing (GE) technologies such as CRISPR 9 (CRISPR-Cas9) related spaces and short palindromic relapse between proteins in reducing the effects of phytohormones, osmolytes, external compounds, proteins, microbes (plant growth-promoting microorganism [PGPM]), approach omics, and drought on plants that support plant growth. This research is to examine the potential of using the microbiome associated with plants for drought resistance and sustainable agriculture. Researchers also advocate using a mix of biotechnology, agronomic, and advanced GE technologies to create drought-tolerant pla...
Source: Bioinformatics and Biology Insights - March 11, 2024 Category: Bioinformatics Authors: Victor Funso Agunbiade Olubukola Oluranti Babalola Source Type: research

Drought Stress Amelioration Attributes of Plant-Associated Microbiome on Agricultural Plants
This article reviews the role of genome editing (GE) technologies such as CRISPR 9 (CRISPR-Cas9) related spaces and short palindromic relapse between proteins in reducing the effects of phytohormones, osmolytes, external compounds, proteins, microbes (plant growth-promoting microorganism [PGPM]), approach omics, and drought on plants that support plant growth. This research is to examine the potential of using the microbiome associated with plants for drought resistance and sustainable agriculture. Researchers also advocate using a mix of biotechnology, agronomic, and advanced GE technologies to create drought-tolerant pla...
Source: Bioinformatics and Biology Insights - March 11, 2024 Category: Bioinformatics Authors: Victor Funso Agunbiade Olubukola Oluranti Babalola Source Type: research

Investigating D-Amino Acid Oxidase Expression and Interaction Network Analyses in Pathways Associated With Cellular Stress: Implications in the Biology of Aging
This study investigates the effect of DAO knockdown using clustered regularly interspaced short palindromic repeats (CRISPR) through an in silico approach on its protein-protein interactions (PPIs) and their potential roles in the process of aging. The target sequence and guide RNA of DAO were designed using the CCTop database, PPI analysis using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses, Reactome biological pathway, protein docking using GalaxyTongDock database, and structure analysis. The translated tar...
Source: Bioinformatics and Biology Insights - March 1, 2024 Category: Bioinformatics Authors: V Kalidasan Darshinie Suresh Nurulisa Zulkifle Yap Siew Hwei Leong Kok Hoong Reena Rajasuriar Kumitaa Theva Das Source Type: research

Investigating D-Amino Acid Oxidase Expression and Interaction Network Analyses in Pathways Associated With Cellular Stress: Implications in the Biology of Aging
This study investigates the effect of DAO knockdown using clustered regularly interspaced short palindromic repeats (CRISPR) through an in silico approach on its protein-protein interactions (PPIs) and their potential roles in the process of aging. The target sequence and guide RNA of DAO were designed using the CCTop database, PPI analysis using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses, Reactome biological pathway, protein docking using GalaxyTongDock database, and structure analysis. The translated tar...
Source: Bioinformatics and Biology Insights - March 1, 2024 Category: Bioinformatics Authors: V Kalidasan Darshinie Suresh Nurulisa Zulkifle Yap Siew Hwei Leong Kok Hoong Reena Rajasuriar Kumitaa Theva Das Source Type: research