Annual Review of Cell and Developmental Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Neofunctionalization of Toll Signaling in Insects: From Immunity to Dorsoventral Patterning
Annu Rev Cell Dev Biol. 2023 Oct 16;39:1-22. doi: 10.1146/annurev-cellbio-120319-120223.ABSTRACTToll signaling plays a crucial role in pathogen defense throughout the animal kingdom. It was discovered, however, for its function in dorsoventral (DV) axis formation in Drosophila. In all other insects studied so far, but not outside the insects, Toll is also required for DV patterning. However, in insects more distantly related to Drosophila, Toll's patterning role is frequently reduced and substituted by an expanded influence of BMP signaling, the pathway implicated in DV axis formation in all major metazoan lineages. This s...
Source: Annual Review of Cell and Developmental Biology - October 16, 2023 Category: Cytology Authors: Siegfried Roth Source Type: research

The Tubulin Code, from Molecules to Health and Disease
Annu Rev Cell Dev Biol. 2023 Oct 16;39:331-361. doi: 10.1146/annurev-cellbio-030123-032748.ABSTRACTMicrotubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They support intracellular trafficking, cell division, cellular motility, and other essential cellular processes. In many species, both α-tubulin and β-tubulin are encoded by multiple genes with distinct expression profiles and functionality. Microtubules are further diversified through abundant posttranslational modifications, which are added and removed by a suite of enzymes to form complex, stereotyped cellular arrays. The genetic and che...
Source: Annual Review of Cell and Developmental Biology - October 16, 2023 Category: Cytology Authors: Elizabeth D McKenna Stephanie L Sarbanes Steven W Cummings Antonina Roll-Mecak Source Type: research

The Unreasonable Effectiveness of Reaction Diffusion in Vertebrate Skin Color Patterning
Annu Rev Cell Dev Biol. 2023 Oct 16;39:145-174. doi: 10.1146/annurev-cellbio-120319-024414.ABSTRACTIn 1952, Alan Turing published the reaction-diffusion (RD) mathematical framework, laying the foundations of morphogenesis as a self-organized process emerging from physicochemical first principles. Regrettably, this approach has been widely doubted in the field of developmental biology. First, we summarize Turing's line of thoughts to alleviate the misconception that RD is an artificial mathematical construct. Second, we discuss why phenomenological RD models are particularly effective for understanding skin color patterning...
Source: Annual Review of Cell and Developmental Biology - October 16, 2023 Category: Cytology Authors: Michel C Milinkovitch Ebrahim Jahanbakhsh Szabolcs Zakany Source Type: research

When We Publish: Accuracy and Quality Control in the Time of Open Access
Annu Rev Cell Dev Biol. 2023 Oct 16;39:v-ix. doi: 10.1146/annurev-cb-39-091823-100001.NO ABSTRACTPMID:37843927 | DOI:10.1146/annurev-cb-39-091823-100001 (Source: Annual Review of Cell and Developmental Biology)
Source: Annual Review of Cell and Developmental Biology - October 16, 2023 Category: Cytology Authors: Ruth Lehmann Source Type: research

Following the Birth, Life, and Death of mRNAs in Single Cells
Annu Rev Cell Dev Biol. 2023 Oct 16;39:253-275. doi: 10.1146/annurev-cellbio-022723-024045.ABSTRACTRecent advances in single-molecule imaging of mRNAs in fixed and living cells have enabled the lives of mRNAs to be studied with unprecedented spatial and temporal detail. These approaches have moved beyond simply being able to observe specific events and have begun to allow an understanding of how regulation is coupled between steps in the mRNA life cycle. Additionally, these methodologies are now being applied in multicellular systems and animals to provide more nuanced insights into the physiological regulation of RNA meta...
Source: Annual Review of Cell and Developmental Biology - October 16, 2023 Category: Cytology Authors: Bastian T Eichenberger Esther Griesbach Jessica Mitchell Jeffrey A Chao Source Type: research

Mechanisms of Regeneration and Fibrosis in the Endometrium
Annu Rev Cell Dev Biol. 2023 Oct 16;39:197-221. doi: 10.1146/annurev-cellbio-011723-021442.ABSTRACTThe uterine lining (endometrium) regenerates repeatedly over the life span as part of its normal physiology. Substantial portions of the endometrium are shed during childbirth (parturition) and, in some species, menstruation, but the tissue is rapidly rebuilt without scarring, rendering it a powerful model of regeneration in mammals. Nonetheless, following some assaults, including medical procedures and infections, the endometrium fails to regenerate and instead forms scars that may interfere with normal endometrial function ...
Source: Annual Review of Cell and Developmental Biology - October 16, 2023 Category: Cytology Authors: Claire J Ang Taylor D Skokan Kara L McKinley Source Type: research