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Exploring Mechanical Forces Shaping Self-Organization and Morphogenesis During Early Embryo Development
Annu Rev Cell Dev Biol. 2024 Apr 12. doi: 10.1146/annurev-cellbio-120123-105748. Online ahead of print.ABSTRACTEmbryonic development is a dynamic process orchestrated by a delicate interplay of biochemical and biophysical factors. While the role of genetics and biochemistry in embryogenesis has been extensively studied, recent research has highlighted the significance of mechanical regulation in shaping and guiding this intricate process. Here, we provide an overview of the current understanding of the mechanical regulation of embryo development. We explore how mechanical forces generated by cells and tissues play a crucia...
Source: Annual Review of Cell and Developmental Biology - April 12, 2024 Category: Cytology Authors: Hong Huang Shaorong Gao Min Bao Source Type: research

Thymic Mimetic Cells: Ontogeny as Immunology
Annu Rev Cell Dev Biol. 2024 Apr 12. doi: 10.1146/annurev-cellbio-112122-023316. Online ahead of print.ABSTRACTMedullary thymic epithelial cells (mTECs) generate immunological self-tolerance by ectopically expressing peripheral-tissue antigens (PTAs) within the thymus to preview the peripheral self to maturing T cells. Recent work, drawing inspiration from old histological observations, has shown that subtypes of mTECs, collectively termed mimetic cells, co-opt developmental programs from throughout the organism to express biologically coherent groups of PTAs. Here, we review key aspects of mimetic cells, especially as the...
Source: Annual Review of Cell and Developmental Biology - April 12, 2024 Category: Cytology Authors: Daniel A Michelson Diane Mathis Source Type: research

Exploring Mechanical Forces Shaping Self-Organization and Morphogenesis During Early Embryo Development
Annu Rev Cell Dev Biol. 2024 Apr 12. doi: 10.1146/annurev-cellbio-120123-105748. Online ahead of print.ABSTRACTEmbryonic development is a dynamic process orchestrated by a delicate interplay of biochemical and biophysical factors. While the role of genetics and biochemistry in embryogenesis has been extensively studied, recent research has highlighted the significance of mechanical regulation in shaping and guiding this intricate process. Here, we provide an overview of the current understanding of the mechanical regulation of embryo development. We explore how mechanical forces generated by cells and tissues play a crucia...
Source: Annual Review of Cell and Developmental Biology - April 12, 2024 Category: Cytology Authors: Hong Huang Shaorong Gao Min Bao Source Type: research

Thymic Mimetic Cells: Ontogeny as Immunology
Annu Rev Cell Dev Biol. 2024 Apr 12. doi: 10.1146/annurev-cellbio-112122-023316. Online ahead of print.ABSTRACTMedullary thymic epithelial cells (mTECs) generate immunological self-tolerance by ectopically expressing peripheral-tissue antigens (PTAs) within the thymus to preview the peripheral self to maturing T cells. Recent work, drawing inspiration from old histological observations, has shown that subtypes of mTECs, collectively termed mimetic cells, co-opt developmental programs from throughout the organism to express biologically coherent groups of PTAs. Here, we review key aspects of mimetic cells, especially as the...
Source: Annual Review of Cell and Developmental Biology - April 12, 2024 Category: Cytology Authors: Daniel A Michelson Diane Mathis Source Type: research

Exploring Mechanical Forces Shaping Self-Organization and Morphogenesis During Early Embryo Development
Annu Rev Cell Dev Biol. 2024 Apr 12. doi: 10.1146/annurev-cellbio-120123-105748. Online ahead of print.ABSTRACTEmbryonic development is a dynamic process orchestrated by a delicate interplay of biochemical and biophysical factors. While the role of genetics and biochemistry in embryogenesis has been extensively studied, recent research has highlighted the significance of mechanical regulation in shaping and guiding this intricate process. Here, we provide an overview of the current understanding of the mechanical regulation of embryo development. We explore how mechanical forces generated by cells and tissues play a crucia...
Source: Annual Review of Cell and Developmental Biology - April 12, 2024 Category: Cytology Authors: Hong Huang Shaorong Gao Min Bao Source Type: research

Thymic Mimetic Cells: Ontogeny as Immunology
Annu Rev Cell Dev Biol. 2024 Apr 12. doi: 10.1146/annurev-cellbio-112122-023316. Online ahead of print.ABSTRACTMedullary thymic epithelial cells (mTECs) generate immunological self-tolerance by ectopically expressing peripheral-tissue antigens (PTAs) within the thymus to preview the peripheral self to maturing T cells. Recent work, drawing inspiration from old histological observations, has shown that subtypes of mTECs, collectively termed mimetic cells, co-opt developmental programs from throughout the organism to express biologically coherent groups of PTAs. Here, we review key aspects of mimetic cells, especially as the...
Source: Annual Review of Cell and Developmental Biology - April 12, 2024 Category: Cytology Authors: Daniel A Michelson Diane Mathis Source Type: research

Exploring Mechanical Forces Shaping Self-Organization and Morphogenesis During Early Embryo Development
Annu Rev Cell Dev Biol. 2024 Apr 12. doi: 10.1146/annurev-cellbio-120123-105748. Online ahead of print.ABSTRACTEmbryonic development is a dynamic process orchestrated by a delicate interplay of biochemical and biophysical factors. While the role of genetics and biochemistry in embryogenesis has been extensively studied, recent research has highlighted the significance of mechanical regulation in shaping and guiding this intricate process. Here, we provide an overview of the current understanding of the mechanical regulation of embryo development. We explore how mechanical forces generated by cells and tissues play a crucia...
Source: Annual Review of Cell and Developmental Biology - April 12, 2024 Category: Cytology Authors: Hong Huang Shaorong Gao Min Bao Source Type: research

Thymic Mimetic Cells: Ontogeny as Immunology
Annu Rev Cell Dev Biol. 2024 Apr 12. doi: 10.1146/annurev-cellbio-112122-023316. Online ahead of print.ABSTRACTMedullary thymic epithelial cells (mTECs) generate immunological self-tolerance by ectopically expressing peripheral-tissue antigens (PTAs) within the thymus to preview the peripheral self to maturing T cells. Recent work, drawing inspiration from old histological observations, has shown that subtypes of mTECs, collectively termed mimetic cells, co-opt developmental programs from throughout the organism to express biologically coherent groups of PTAs. Here, we review key aspects of mimetic cells, especially as the...
Source: Annual Review of Cell and Developmental Biology - April 12, 2024 Category: Cytology Authors: Daniel A Michelson Diane Mathis Source Type: research

Exploring Mechanical Forces Shaping Self-Organization and Morphogenesis During Early Embryo Development
Annu Rev Cell Dev Biol. 2024 Apr 12. doi: 10.1146/annurev-cellbio-120123-105748. Online ahead of print.ABSTRACTEmbryonic development is a dynamic process orchestrated by a delicate interplay of biochemical and biophysical factors. While the role of genetics and biochemistry in embryogenesis has been extensively studied, recent research has highlighted the significance of mechanical regulation in shaping and guiding this intricate process. Here, we provide an overview of the current understanding of the mechanical regulation of embryo development. We explore how mechanical forces generated by cells and tissues play a crucia...
Source: Annual Review of Cell and Developmental Biology - April 12, 2024 Category: Cytology Authors: Hong Huang Shaorong Gao Min Bao Source Type: research

Thymic Mimetic Cells: Ontogeny as Immunology
Annu Rev Cell Dev Biol. 2024 Apr 12. doi: 10.1146/annurev-cellbio-112122-023316. Online ahead of print.ABSTRACTMedullary thymic epithelial cells (mTECs) generate immunological self-tolerance by ectopically expressing peripheral-tissue antigens (PTAs) within the thymus to preview the peripheral self to maturing T cells. Recent work, drawing inspiration from old histological observations, has shown that subtypes of mTECs, collectively termed mimetic cells, co-opt developmental programs from throughout the organism to express biologically coherent groups of PTAs. Here, we review key aspects of mimetic cells, especially as the...
Source: Annual Review of Cell and Developmental Biology - April 12, 2024 Category: Cytology Authors: Daniel A Michelson Diane Mathis Source Type: research

Exploring Mechanical Forces Shaping Self-Organization and Morphogenesis During Early Embryo Development
Annu Rev Cell Dev Biol. 2024 Apr 12. doi: 10.1146/annurev-cellbio-120123-105748. Online ahead of print.ABSTRACTEmbryonic development is a dynamic process orchestrated by a delicate interplay of biochemical and biophysical factors. While the role of genetics and biochemistry in embryogenesis has been extensively studied, recent research has highlighted the significance of mechanical regulation in shaping and guiding this intricate process. Here, we provide an overview of the current understanding of the mechanical regulation of embryo development. We explore how mechanical forces generated by cells and tissues play a crucia...
Source: Annual Review of Cell and Developmental Biology - April 12, 2024 Category: Cytology Authors: Hong Huang Shaorong Gao Min Bao Source Type: research

Thymic Mimetic Cells: Ontogeny as Immunology
Annu Rev Cell Dev Biol. 2024 Apr 12. doi: 10.1146/annurev-cellbio-112122-023316. Online ahead of print.ABSTRACTMedullary thymic epithelial cells (mTECs) generate immunological self-tolerance by ectopically expressing peripheral-tissue antigens (PTAs) within the thymus to preview the peripheral self to maturing T cells. Recent work, drawing inspiration from old histological observations, has shown that subtypes of mTECs, collectively termed mimetic cells, co-opt developmental programs from throughout the organism to express biologically coherent groups of PTAs. Here, we review key aspects of mimetic cells, especially as the...
Source: Annual Review of Cell and Developmental Biology - April 12, 2024 Category: Cytology Authors: Daniel A Michelson Diane Mathis Source Type: research

Exploring Mechanical Forces Shaping Self-Organization and Morphogenesis During Early Embryo Development
Annu Rev Cell Dev Biol. 2024 Apr 12. doi: 10.1146/annurev-cellbio-120123-105748. Online ahead of print.ABSTRACTEmbryonic development is a dynamic process orchestrated by a delicate interplay of biochemical and biophysical factors. While the role of genetics and biochemistry in embryogenesis has been extensively studied, recent research has highlighted the significance of mechanical regulation in shaping and guiding this intricate process. Here, we provide an overview of the current understanding of the mechanical regulation of embryo development. We explore how mechanical forces generated by cells and tissues play a crucia...
Source: Annual Review of Cell and Developmental Biology - April 12, 2024 Category: Cytology Authors: Hong Huang Shaorong Gao Min Bao Source Type: research

Thymic Mimetic Cells: Ontogeny as Immunology
Annu Rev Cell Dev Biol. 2024 Apr 12. doi: 10.1146/annurev-cellbio-112122-023316. Online ahead of print.ABSTRACTMedullary thymic epithelial cells (mTECs) generate immunological self-tolerance by ectopically expressing peripheral-tissue antigens (PTAs) within the thymus to preview the peripheral self to maturing T cells. Recent work, drawing inspiration from old histological observations, has shown that subtypes of mTECs, collectively termed mimetic cells, co-opt developmental programs from throughout the organism to express biologically coherent groups of PTAs. Here, we review key aspects of mimetic cells, especially as the...
Source: Annual Review of Cell and Developmental Biology - April 12, 2024 Category: Cytology Authors: Daniel A Michelson Diane Mathis Source Type: research

Exploring Mechanical Forces Shaping Self-Organization and Morphogenesis During Early Embryo Development
Annu Rev Cell Dev Biol. 2024 Apr 12. doi: 10.1146/annurev-cellbio-120123-105748. Online ahead of print.ABSTRACTEmbryonic development is a dynamic process orchestrated by a delicate interplay of biochemical and biophysical factors. While the role of genetics and biochemistry in embryogenesis has been extensively studied, recent research has highlighted the significance of mechanical regulation in shaping and guiding this intricate process. Here, we provide an overview of the current understanding of the mechanical regulation of embryo development. We explore how mechanical forces generated by cells and tissues play a crucia...
Source: Annual Review of Cell and Developmental Biology - April 12, 2024 Category: Cytology Authors: Hong Huang Shaorong Gao Min Bao Source Type: research