Antifungal chemosensitization through induction of oxidative stress: A model for control of candidiasis based on the Lippia origanoides essential oil
An Acad Bras Cienc. 2024 Apr 5;96(1):e20230532. doi: 10.1590/0001-3765202420230532. eCollection 2024.ABSTRACTIn this work, evaluated the antifungal chemosensitizing effect of the Lippia origanoides essential oil (EO) through the induction of oxidative stress. The EO was obtained by hydrodistillation and analyzed by GC-MS. To evaluate the antifungal chemosensitizing effect through induction of oxidative stress, cultures of the model yeast Saccharomyces cerevisiae ∆ycf1 were exposed to sub-inhibitory concentrations of the EO, and the expression of genes known, due be overexpressed in response to oxidative and mutagenic str...
Source: An Acad Bras Cienc - April 10, 2024 Category: Science Authors: Sandra Layse F Sarrazin Jean-Paul Bourdineaud Jos é Guilherme S Maia Rosa Helena V Mour ão Ricardo B Oliveira Source Type: research
Synthesis and mechanistic study of 2-(trifluoromethyl)-10H-phenoselenazine from double cross coupling reaction
An Acad Bras Cienc. 2024 Apr 5;96(1):e20230745. doi: 10.1590/0001-3765202420230745. eCollection 2024.ABSTRACTPhenoselenazines are nitrogen and selenium-based heterocyclic compounds that have important biological activities. However, their preparation methods are scarce and difficult to handle. The synthesis of a phenoselenazine from a simple and robust CuO nanoparticle catalyzed methodology, using bis-aniline-diselenide and 1,2-dihalobenzenes under microwave irradiation. Also, the double-cross-coupling reaction mechanism for C-Se and C-N bond formation, including the observation of a reaction intermediate by mass spectrome...
Source: An Acad Bras Cienc - April 10, 2024 Category: Science Authors: C ássio Siqueira Gianluca Ciancaleoni Sumbal Saba Antonio L Braga Jamal Rafique Giancarlo V Botteselle Source Type: research
Reactive oxygen species impair Na+ transport and renal components of the renin-angiotensin-aldosterone system after paraquat poisoning
This study evaluated how ROS acutely influences Na+-transporting ATPases and the renal RAAS. Adult male Wistar rats received paraquat (20 mg/kg; ip). After 24 h, we observed body weight loss and elevation of urinary flow and serum creatinine. In the renal cortex, paraquat increased ROS levels, NADPH oxidase and (Na++K+)ATPase activities, angiotensin II-type 1 receptors, tumor necrosis factor-α (TNF-α), and interleukin-6. In the medulla, paraquat increased ROS levels and NADPH oxidase activity but inhibited (Na++K+)ATPase. Paraquat induced opposite effects on the ouabain-resistant Na+-ATPase in the cortex (decrease) and m...
Source: An Acad Bras Cienc - April 10, 2024 Category: Science Authors: Marry A S Cirilo Val éria B S Santos Nat ália K S Lima Humberto Muzi-Filho Ana D O Paix ão Adalberto Vieyra Leucio D Vieira Source Type: research
Evolution of the redox-altered, two-tiered Muralha Flow in the Fronteira Oeste Rift, southern Paran á Volcanic Province
An Acad Bras Cienc. 2024 Apr 5;96(1):e20231088. doi: 10.1590/0001-3765202420231088. eCollection 2024.ABSTRACTThe thorough redox alteration of a lava flow is an undescribed feature in intraplate basaltic provinces. The Early Cretaceous (134.5 Ma) Paraná Province displays that alteration in the major Muralha Flow. This oxidized and reduced flow from the southern part of the province was studied with satellite images, field surveying, petrography, and published whole rock geochemistry. The 100 x 100 km flow from the Cuesta de Haedo presents two hydrothermal tiers - lower Tier 1 is gray to white, upper Tier 2 is red. Iron oxy...
Source: An Acad Bras Cienc - April 10, 2024 Category: Science Authors: L éo A Hartmann Leonardo Cardoso Renner Eduarda Klabunde Source Type: research
A preliminary study of cutaneous wound healing on the upper eyelid in a small Brazilian population using Rhizophora mangle-based cream
This study aimed to evaluate the effectiveness of the 5% Rhizophora mangle cream compared to the 5% dexpanthenol cream in healing open surgical wounds on the upper eyelid. A total of 18 patients were submitted to the experiment and divided into 2 groups with 9 patients each who used topically and daily 5% dexpanthenol cream (control group) or 5% R.mangle cream (intervention group) for 7 days. Clinical, morphometric and histomorphometric analyses of wounds and surgical procedures for skin removal were performed. In the morphometric analysis, all wounds treated with R.mangle and dexpanthenol creams showed complete macroscopi...
Source: An Acad Bras Cienc - April 10, 2024 Category: Science Authors: Jerrar J X Silva Leila B Leal J éssica G A Sá Larissa R A Sabino Isabelle M F S D Cavalcanti Luzia A Silva Eduarda S DE Santana Fernando Henrique P Fernandes Iranildo Jos é C Filho Wesley F M Brand ão Jeymesson Raphael C Vieira Source Type: research
Effect of seasonality and estuarine waters on the phytoplankton of the Guam á River (Belém, Amazon, Brazil)
This study aimed to analyze the application of the Phytoplankton Community Index-PCI and Functional Groups-FG in determining the water quality of the Guamá River (Pará, Amazônia, Brazil). Samplings occurred monthly for analyses of phytoplankton and physical and chemical parameters, for two years, at the station where water was collected for human supply consumption. Seasonality influenced electrical conductivity, total suspended solids, dissolved oxygen, transparency, winds, true color, and N-ammoniacal. The ebb tide showed high turbidity and suspended solids. The density varied seasonally with the highest values occurr...
Source: An Acad Bras Cienc - April 10, 2024 Category: Science Authors: Paola Vitoria B Pires Eliane B DE Sousa Aline L Gomes Celly Jenniffer S Cunha Vanessa B DA Costa Tavares Samara Cristina C Pinheiro Bruno S Carneiro Nuno Filipe A C DE Melo Source Type: research
Huanglian Decoction treats Henoch-Schonlein purpura nephritis by inhibiting NF- κB/NLRP3 signaling pathway and reducing renal IgA deposition
This study aimed to investigate the protective mechanism of HLD treatment in HSPN. The effects of HLD on HSPN biochemical indices, kidney injury and NF-κB/NLRP3 signaling pathway were analyzed by biochemical analysis, ELISA, HE and PAS staining, immunohistochemistry, immunofluorescence, and Western Blot. In addition, the effects of HLD on HSPN cells were analyzed. We found that HLD treatment significantly reduced renal tissue damage, decreased the levels of IL-17, IL-18, TNF-α, and IL-1β, and increased the levels of TP and ALB in HSPN mice. It also inhibited the deposition of IgA, IgG, and C3 in kidney tissues and signi...
Source: An Acad Bras Cienc - April 10, 2024 Category: Science Authors: Lian Hu Linlin Li Hong Che Bingjie Zhao L I Xiao Peijia Liu Wenjing Yi Songshan Liu Source Type: research
Hippocampal acetylcholinesterase activation induced by streptozotocin in mice is protected by an organotellurium compound without evidence of toxicity
This study aimed to evaluate if the tellurium-containing organocompound, 3j, 5'-arylchalcogeno-3-aminothymidine derivative, interferes with the effects of streptozotocin, as well as to investigate its toxicity in adult mice. Cognitive deficit was induced by two doses of streptozotocin (2.25 mg/kg/day, 48 h interval) intracerebroventricularly. After, the mice were subcutaneously treated with 3j (8.62 mg/kg/day) for 25 days. The effects were assessed by evaluating hippocampal and cortical acetylcholinesterase and behavioral tasks. 3j toxicity was investigated for 10 (0, 21.55, or 43.10 mg/kg/day) and 37 (0, 4.31, or 8.62 mg/...
Source: An Acad Bras Cienc - April 10, 2024 Category: Science Authors: Nilce C Peixoto Jamile S Bernardi Cl áudia S Oliveira Mariana Suelen C Santos Sara L Marion Rafael S Silva Raquel M Rosa Oscar E D Rodrigues Maria Ester Pereira Source Type: research
Green manure (Crotalaria juncea L.) enhances Origanum vulgare L. biomass accumulation, essential oil yield, and phytochemical properties
The objectives of this study were to evaluate the GM on biomass, essential oil (EO), phenolic and antioxidant. The experiment consisted: control; 150, 300, 450, and 600 g (Sh= leaves+steam) more 200 g roots (R); 600 g aerial part; 200 g roots; and soil with 300 g cattle manure per pot. The highest dry weights were observed in the presence of GM and cattle manure (90 days). The control had an EO production 75% lower in relation to the dose of 450 g GM (Sh+R). Principal component analysis showed that GM and cattle manure positively influenced the dry weight, content, yield, and EO constituents, and total flavonoids. The GM c...
Source: An Acad Bras Cienc - April 10, 2024 Category: Science Authors: Rafael M A DE Assis Jandeilson P Dos Santos Alan DA Cunha Honorato Jo ão Pedro M Rocha Alexandre A DE Carvalho Suzan Kelly V Bertolucci Jos é Eduardo B P Pinto Source Type: research
The effect of linseed oil/canola oil blend on the coating and thermal properties of waste PET-based alkyd resins
This study aims to prepare oil-modified alkyd resins using a linseed oil/canola oil (LO/CO) blend and waste PET depolymerization product, suitable for environmentally friendly coating applications. Waste PET flakes obtained from grinding post-consumer water bottles were depolymerized by the aminoglycolysis reaction at high pressure. Raw depolymerization product (DP) was used in the synthesis of four components, 50% oil alkyd resins by monoglyceride method. DP has partly replaced the dibasic acid component in the PET-based alkyd formulations. Besides PET-based alkyds, reference alkyds without DP were also synthesized for co...
Source: An Acad Bras Cienc - April 10, 2024 Category: Science Authors: Tu ğba Erol Demet H Özaltun Ferda Civan Çavuşoğlu I şil Acar Gamze G üçlü Source Type: research
Taxonomic study of Hymenochaetaceae species (Agaricomycetes, Basidiomycota) in the municipalities of Tom é-Açu and Bujaru, Pará, Brazil
An Acad Bras Cienc. 2024 Apr 5;96(suppl 1):e20230338. doi: 10.1590/0001-3765202420230338. eCollection 2024.ABSTRACTThe family Hymenochaetaceae includes a diversity of 893 species described around the world. Its representatives are known by their usually rusty colored basidiomes with a poroid hymenial surface, hydnoid or smooth, woody consistency, and wide morphological variation regarding the arrangement on the substrate. They behave as saprophytic, parasitic, ectomycorrhizal and play a fundamental role in the decomposition of wood in forest ecosystems. In the Brazilian Amazonia region, approximately 40 species of Hymenoch...
Source: An Acad Bras Cienc - April 10, 2024 Category: Science Authors: Richard Bruno M Freire Adriene Mayra S Soares Source Type: research
Development of benzaldehyde-pyrazoline hybrids for functionalization of polymers with fluorescent pendant moieties
An Acad Bras Cienc. 2024 Mar 18;96(1):e20220875. doi: 10.1590/0001-3765202420220875. eCollection 2024.ABSTRACTCompounds with a pyrazoline scaffold are useful as sensors for fluorescence detection of different types of analytes. Recovery of a pyrazoline-based sensor with a view to use it recurrently would be more facile when the sensing molecule is attached to a solid support. A reaction sequence has been designed to synthesize two benzaldehyde-pyrazoline hybrids as examples of a hitherto unknown type of compounds to be employed for the potential derivatization of polymers containing primary amino groups through azomethine ...
Source: An Acad Bras Cienc - March 21, 2024 Category: Science Authors: Gheorghe Roman Mihaela Balan-Porc ăraşu Liviu S ăcărescu Source Type: research
Distribution of gamma-ray elements in Cerro do Jarau impact structure and a proposal of geothermal modeling
This study collected ground gamma-ray data over the structure and produced K, eTh and eU concentrations, eTh/K ratio and F-factor maps to characterize it in terms of its radiometric signatures and their respective spatial distribution. A general decrease in the concentration of the three elements was observed from the outer-rim towards the center of the crater. The central area is defined by very low radiometric values, with relatively high K values, thus indicating the occurrence of K-bearing rocks. Numerical simulations using the HYDROTHERM 3 code showed the fluid circulation pattern over the impact structure. Data inter...
Source: An Acad Bras Cienc - March 21, 2024 Category: Science Authors: Diego D Garcia Emilson P Leite Marcos Alberto R Vasconcelos Evangelos Christou Alvaro P Cr ósta Source Type: research
Influence of Chemical Nature of Citric and Tartaric Acids on Reaction Time of the Crosslinking of Polyvinyl Alcohol Hydrogels
In this study, PVOH hydrogels were synthesized by a solution under stirring and heating techniques with citric (AC) and tartaric acids (AT) crosslinker agents, with different time reactions of 20 min.; 1; 2, and 3 h were investigated. These samples were characterized by the kinetics of water uptake, gel fraction, thermal analysis, and physical-chemical analysis, and their structure was elucidated. The results obtained have shown chemical modification by organic acids and improved the properties to good thermal stability and swelling to AT hydrogels up to 900% water uptake. In the gel fraction, the samples' esterification w...
Source: An Acad Bras Cienc - March 21, 2024 Category: Science Authors: Dione P DE Castro Ruth Marlene C Santana Source Type: research
Sequential extraction of anthocyanins and pectin from jabuticaba (Plinia cauliflora) peel: Peel pretreatment effect and ultrasound-assisted extraction
The objective was to evaluate the effect of pretreatment and fresh use of jabuticaba peels in the extraction of total phenolic compound (TPC) and total anthocyanin (TA) contents with and without ultrasound assistance and in the sequential extraction of pectin from the residue. In the TPC and TA extraction, a 3x2 factorial design was used. For conventional anthocyanin extraction (CAE), occurred in an incubator under agitation. For ultrasound-assisted anthocyanin extraction (UAE) was utilized an ultrasonic homogenizer with probe (20 kHz, 160 W). The extracts were quantified (TPC, TA, antioxidant activity and color). The resi...
Source: An Acad Bras Cienc - March 21, 2024 Category: Science Authors: Tainah M Bueno Fabiana Queiroz Jhenifer Cristina C Dos Santos Maria Luiza B Furtado Maria Cec ília E V Schiassi Soraia V Borges Jayne A Figueiredo Source Type: research
