Diagnostic and prognostic value of c-MYC gene expression in hematological malignancies
Conclusion: Plasma c-MYC ratio showed promising screening/diagnostic value for hematological malignancies.Keywords: c-MYC; c-MYC screening; prognosis with c-MYC; hematological malignancies; plasma c-MYC; c-MYC in malignancies;c-MYC expression. (Source: African Health Sciences)
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: Ifeyinwa Maryann Okafor, Henshaw Uchechi Okoroiwu, Christopher Ogar Ogar Source Type: research
Mir-21 and Mir-125b as theranostic biomarkers for epithelial ovarian cancer in Tunisian women
Conclusions: Our data suggest that miR-21 and miR-125b in plasma may serve as potential circulating biomarkers for the early detection of EOC. MiR-125b may also be useful for predicting chemosensitivity in EOC patients.Keywords: Epithelial ovarian cancer; miRNAs; biomarkers; resistance to treatment; Tunisia. (Source: African Health Sciences)
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: A Habel, F Nassar, M Itani, H Bouaziz, M Hadj-Ahmed, Z Msheik, M Stayoussef, R Nasr, B Yacoubi-Loueslati Source Type: research
Expression of miR-152 in cervical cancer and its influence on cisplatin resistance
Conclusion: MiR-152 suppresses the proliferation, migration and infiltration of cervical cancer cells and reduces their resistanceto DDP chemotherapy by inhibiting the expressions of proteins in the ERBB3/Akt/c-myc and ERBB3/Akt/Snail pathways.Keywords: miR-152; cervical cancer; cisplatin; drug resistance. (Source: African Health Sciences)
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: Jun Wu, Xiaoping Chi, Qian Yang, Jinxiao Li Source Type: research
Associations of blood glucose, helper T cells and cytokine levels with degree of periodontal lesion in type 2 diabetes mellitus patients accompanied by chronic periodontitis
Conclusion: High levels of FPG, HbA1c, IFN- γ and IL-17 are independent risk factors for T2DM accompanied by CP.Keywords: Type 2 diabetes mellitus; chronic periodontitis; blood glucose; helper T cell; cytokine; periodontal lesion. (Source: African Health Sciences)
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: Cheng Wang, Bing Zhou Source Type: research
Risk factors for pancreatitis occurrence after gallstone treatment using endoscopic retrograde cholangiopancreatography
Conclusion: Patients with gallstones have a higher risk of developing pancreatitis. Young age, long course of disease, gallbladder wall thickness>3 mm, sand-like stones, history of pancreatic disease, pancreatic duct visualization and number of intubation ≥2 are risk factors for post-ERCP pancreatitis.Keywords: risk factor; endoscopic retrograde cholangiopancreatography; pancreatitis; gallstone; pancreatic duct stenting. (Source: African Health Sciences)
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: Feibao Jiang, Jilong Zhang, Zhenghua Hu Source Type: research
Effect of whole course seamless nursing mode on patients with chronic infectious wounds
Conclusion: For patients with chronic infectious wounds, whole course seamless nursing effectively relieves wound pain, facilitateswound healing, improves comfort, psychological state and sleep status, and makes them more satisfied.Keywords: Chronic infectious wound; whole course seamless nursing; quality of life. (Source: African Health Sciences)
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: Yun Peng, Chenlu Gao, Yan Sun Source Type: research
Irrational use of antibiotics without a clinical diagnosis: a short case report
We report a case of a 40-year-old male who was treated intermittently with multiple antibiotics for 3 months without being clinically diagnosed. The patient continued having episodes of fever with brief periods of remission. The occurrence of recurrent episodes of transient ischemic attacks alarmed him, and he was brought to a tertiary hospital, where a diagnosis of culture-negative Infective Endocarditis (IE) was made. He underwent successful high-risk double valve replacement and was discharged from the hospital in satisfactory condition.Key messages: Antibiotics should be started judiciously with a proper clinical indic...
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: Rajat Agarwal, Mohd Mubeen, Harpreet Singh Source Type: research
Genotypic characterization of extended spectrum beta-lactamase in gram negative bacterial contaminants of some door handles in Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun state
Conclusion: This study revealed that door handles of different sections in hospital environment were contaminated by multidrug resistant Gram-negative bacteria encoding ESBL genes.Keywords: Bacterial contamination; drug resistance; extended spectrum beta-lactamase. (Source: African Health Sciences)
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: Oluwatoyin Bola Famojuro, Ifeoluwa Omolola Adesanya, Jerome Olu Ajewole, Tayo Ibukun Famojuro Source Type: research
Predictive value of platelet-related parameters combined with pneumonia severity index score for mortality rate of patients with severe pneumonia
Conclusion: PLT, PDW, MPV and P-LCR are significantly abnormal in patients with severe pneumonia, and the combination of platelet-related parameters with PSI score has the highest predictive value for 28-day mortality.Keywords: Platelet-related parameter; pneumonia severity index score; prediction; severe pneumonia. (Source: African Health Sciences)
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: Jing Wang, Lei Cui, Zhengliang Guo Source Type: research
Challenges and recommendations for addressing under-five pneumonia morbidity and mortality in Nigeria
Conclusions: The results from this study highlight contextual issues playing major roles in pneumonia mortality among childrenin Nigeria, which will need approaches on several levels to address them.Keywords: Pneumonia; children; under five mortality; Nigeria; vaccinations; barriers. (Source: African Health Sciences)
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: Chidi Okafor, Abimbola Olaniran, Elisabeth Darj Source Type: research
Antibody response to pneumococcal conjugate vaccine 10 among Nigerian children under 5 years
Conclusion: All the children under the age of five years who had received PCV 10 at 6, 10 and 14 weeks of age, who participated in this study formed protective levels of antibodies to the vaccine. Antibody levels increased slightly with age. The PCV 10 currently used in the Nigerian programme is sufficiently antigenic and a downward trend in pneumococcal diseases should soon be noticeable.Keywords: Pneumococcal conjugate vaccine; antibody; children; Nigeria. (Source: African Health Sciences)
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: Chidinma A Udah, Francis U Iregbu, Emmanuel E Ekanem Source Type: research
Correlation between vaginal flora and cervical immune function of human papilloma virus-infected patients with cervical cancer
Conclusion: High-risk HPV infection in patients with cervical cancer was associated with vaginal flora and immune function.C. trachomatis and U. urealyticum were independent risk factors for high-risk HPV infection.Keywords: Cervical cancer; human papilloma virus; immune function; vaginal flora. (Source: African Health Sciences)
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: Qiang Wang, Wenmin Qin, Wei Gao, Kai Zhao, Xiaohong Pan, Xiaofei Jiang, Juan Zhao Source Type: research
Antiviral use among hepatitis B infected patients in a low resource setting in Africa: a case study of West Nile, Uganda
Failure to access antiviral medications is a leading cause of hepatitis B (HBV)-associated morbidity and mortality in sub-Saharan Africa (SSA). Despite guideline availability, SSA is not on course to meet its elimination targets. We characterized factors associated with antiviral medication use and challenges to offering chronic care in a large Ugandan institution. We abstracted HBV care data. 2,175/2,209 (98.5%) had HBV-infection. Most participants were men [1,197 (55%)]; median (IQR) age 27 years (19-35); 388/1689 (23.0%) had cirrhosis by sonography and 141/2175 (6.5%) by the aspartate aminotransferase to platelet ratio ...
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: Emmanuel Seremba, Claude Wandera, Richard Ssekitoleko, Joan Nankya-Mutyoba, Filbert Nyeko, Jacinto Amandua, David Ejalu, William Omale, Ponsiano Ocama Source Type: research
Prevalence of hepatitis B and C, and syphilis among aspirant migrant workers of Bangladesh
Conclusion: Diagnosis of diseases of workers is obligatory before going abroad to safeguard the health of the workers and residents of destination country. Consequently, it will contribute to reducing the global burden of infectious diseases.Keywords: Aspirant migrant workers; Hepatitis B and C; syphilis. (Source: African Health Sciences)
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: Jinia Afroz, Fatema Tuz Jubyda, Sanzida Sharmin, Masud Rana, Amit Kumar Dey, Tasmia Farzana, Murshed Hasan Sarkar Source Type: research
Bibliometric structured review of tuberculosis in Nigeria
This study builds on the existing study that examined academic involvement in tuberculosis research. The study in question focused on global medical literature related to tuberculosis, but the non-visibility of some low and middle-income countries in the bigger global picture motivated this present study. Every year, over 245,000 Nigerians succumb to tuberculosis (TB), with approximately 590,000 new cases reported (of these, around 140,000 are also HIV-positive). This study carried out an academic publication evaluation with the VOS viewer tool to map bibliometric data for scholarly articles published between 1991 and 2021...
Source: African Health Sciences - July 13, 2023 Category: African Health Authors: Sunday Adewale Olaleye, Oluwafemi Samson Balogun, Frank Adusei-Mensah Source Type: research
