Functionalization of selenium nanoparticles with olive polyphenols - impact on toxicity and antioxidative activity
Acta Pharm. 2023 Dec 26;73(4):617-631. doi: 10.2478/acph-2023-0036. Print 2023 Dec 1.ABSTRACTSelenium nanoparticles (SeNPs) represent novel selenium (Se) formulation characterized by improved biocompatibility and a wider therapeutic range in comparison to inorganic Se. The aim of this work was to investigate the possibilities of functionalization of SeNPs with olive pomace extract (OPE), rich in health-promoting polyphenols, and to obtain innovative forms of nutraceuticals. Cytotoxic and antioxidative activities of four types of SeNPs (polyvinylpyrrolidone stabilized (PVP SeNPs), polysorbate stabilized (PS SeNPs), polyviny...
Source: Acta Pharmaceutica - December 26, 2023 Category: Drugs & Pharmacology Authors: Emerik Gali ć Kristina Radi ć Nikolina Golub Jakov Mlinar Dubravka Vitali Čepo Tomislav Vinkovi ć Source Type: research
Beliefs about medicines' association with endocrine therapy adherence in early breast cancer survivors in Croatia
Acta Pharm. 2023 Dec 26;73(4):673-689. doi: 10.2478/acph-2023-0043. Print 2023 Dec 1.ABSTRACTThis observational, cross-sectional study conducted at the University Hospital Centre Zagreb (UHC Zagreb) aimed to explore patients' beliefs about adjuvant endocrine therapy (AET) as well as their association with non-adherence and sociodemographic and clinical factors. Out of 420 early breast cancer (BC) patients included in the study, 79.5 % perceived AET necessary and important for their health, as measured by the Belief About Medicines Questionnaire (BMQ), with the mean necessity score (20.4 ± 3.68) significantly higher than t...
Source: Acta Pharmaceutica - December 26, 2023 Category: Drugs & Pharmacology Authors: Ana Dugonji ć Okroša Tajana Silovski Natalija Dedi ć Plavetić Hrvoje Silovski Ana Kova čić Iva Mucalo Source Type: research
Preparation of astaxanthin/zeaxanthin-loaded nanostructured lipid carriers for enhanced bioavailability: Characterization-, stability-and permeability study
This study provides useful data about the advantages of using NLC as a delivery system for ASTA and ZEA that might facilitate their applications in the food and pharmaceutical industry.PMID:38147480 | DOI:10.2478/acph-2023-0038 (Source: Acta Pharmaceutica)
Source: Acta Pharmaceutica - December 26, 2023 Category: Drugs & Pharmacology Authors: Kristina Radi ć Ana Isabel Barbosa Salette Reis Marijan Marijan Sofia Antunes Costa Lima Dubravka Vitali Čepo Source Type: research
Exploring adherence in patients with advanced breast cancer: focus on CDK4/6 inhibitors
This study enhances understanding of medication adherence in advanced breast cancer and identifies influential factors.PMID:38147481 | DOI:10.2478/acph-2023-0045 (Source: Acta Pharmaceutica)
Source: Acta Pharmaceutica - December 26, 2023 Category: Drugs & Pharmacology Authors: Matea Bakovi ć Martina Bago Lucija Beni ć Magdalena Krajinovi ć Tajana Silovski Natalija Dedi ć Plavetić Lu Turkovi ć Miranda Serti ć Maja Ortner Had žiabdić Source Type: research
Synthesis, antiproliferative and antiplasmodial evaluation of new chloroquine and mefloquine-based harmiquins
Acta Pharm. 2023 Dec 26;73(4):537-558. doi: 10.2478/acph-2023-0035. Print 2023 Dec 1.ABSTRACTHere we present the synthesis and evaluation of the biological activity of new hybrid compounds, ureido-type (UT) harmiquins, based on chloroquine (CQ) or mefloquine (MQ) scaffolds and β-carboline alkaloid harmine against cancer cell lines and Plasmodium falciparum. The hybrids were prepared from the corresponding amines by 1,1'-carbonyldiimidazole (CDI)-mediated synthesis. In vitro evaluation of the biological activity of the title compounds revealed two hit compounds. Testing of the antiproliferative activity of the new UT harmi...
Source: Acta Pharmaceutica - December 26, 2023 Category: Drugs & Pharmacology Authors: Kristina Pavi ć Goran Poje Lais Pessanha De Carvalho Jana Held Zrinka Raji ć Source Type: research
