Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway
In conclusion, deguelin treatment, when applied in vitro, induced apoptotic cell death and resulted in mitotic cessation at the G2/M phase through modulation of cell cycle regulatory mRNAs in multiple myeloma cells.PMID:38554386 | DOI:10.2478/acph-2024-0003 (Source: Acta Pharmaceutica)
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Kening Sun Ping Chen Liang Zhang Zhidong Lu Qunhua Jin Source Type: research
Medicarpin suppresses lung cancer cell growth < em > in vitro < /em > and < em > in vivo < /em > by inducing cell apoptosis
This study was de sig ned to evaluate the anti-LC effect and reveal the underlying mechanisms of MED in vivo and in vitro. We found that MED could significantly inhibit proliferation, induce apoptosis, and cell cycle arrest of A549 and H157 cell lines. Basically, MED induced cell apoptosis of LC cells by upregu lating the expression of pro-apoptotic proteins BAX and Bak1, leading to the cleavage of caspase-3 (Casp3). Moreover, MED inhibited the proliferation of LC cells via downregulating the expression of proliferative protein Bid. Overall, MED inhibited LC cell growth in vitro and in vivo via suppressing cell proliferati...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Zongyi Shen Liqi Yin Manxia Chang Haifeng Wang Mingxuan Hao Youfeng Liang Rui Guo Ying Bi Jiansong Wang Changyuan Yu Jinmei Li Qiongli Zhai Runfen Cheng Jinku Zhang Jirui Sun Zhao Yang Source Type: research
Chemical composition and potential antioxidant, anti-inflammatory, and analgesic efficacy of < em > Cistus albidus < /em > L
This study aims to assess the chemical composition of the aqueous extract of Cistus albidus L. leaves, as well as the potential of aqueous and hydroethanol extracts of the leaves and seeds as analgesic, anti--inflammatory, and antioxidant agents. The contents of phenolics and inorganic constituents were determined in C. albidus seeds and leaves; antioxidant capacity was assessed by 3 complementary and diverse tests. The carrageenan-induced paw edema technique was used to investigate the anti-inflammatory effect in vivo, and albumin denaturation to evaluate the anti-inflammatory effect in vitro. The acetic acid-induced cont...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Aziz Zouhri Toufik Bouddine Naoual El Menyiy Yahya El-Mernissi Hassan Laaroussi Mohamed Chebaibi Hassan Amhamdi Abdelhay Elharrak Hiba-Allah Nafidi Baye Sitotaw Yousef A Bin Jardan Mohammed Bourhia Lhoussain Hajji Source Type: research
Characterization of mineral composition of leaves and flowers of wild-growing < em > Sambucus nigra < /em >
The objective of this study was to determine the mineral content in the leaves and flowers of wild-grown Sambucus nigra collected from eleven different locations in Kosovo. The samples were digested in a microwave system using the wet digestion method. The minerals were determined by the application of inductively coupled plasma-atomic emission spectrometry (ICP-AES) and inductively coupled plasma-mass spectrometry (ICP-MS). A total of 31 elements were determined, 15 elements by the ICP-AES method (Al, B, Ba, Ca, Cr, Cu, Fe, K, Mg, Mn, Na, P, Sr, V, and Zn) and 16 elements by the ICP-MS method (Ag, As, Be, Bi, Cd, Co, Cs, ...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Bujar Qazimi Traj če Stafilov Katerina Ba čeva Andonovska Krste Ta šev Nikola Geskovski Shpend Dragusha Hyrije Koraqi Valon Ejupi Source Type: research
Furanocoumarin compounds isolated from < em > Dorstenia foetida < /em > potentiate irinotecan anticancer activity against colorectal cancer cells
In conclusion, our results identified compound 2 as a plant-derived compound exhibiting anticancer properties that can act synergistically with Iri and warranted further research to assess the potential of this synergism for colorectal cancer treatment.PMID:38554381 | DOI:10.2478/acph-2024-0004 (Source: Acta Pharmaceutica)
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Supusson Pengnam Watcharapa Jitkaroon Roongtiwa Srisuphan Pawaris Wongprayoon Kanok-On Rayanil Purin Charoensuksai Source Type: research
Novel ( ±)- < em > trans < /em > - < em > β < /em > -lactam ureas: Synthesis, < em > in silico < /em > and < em > in vitro < /em > biological profiling
Acta Pharm. 2024 Mar 30;74(1):37-59. doi: 10.2478/acph-2024-0008. Print 2024 Mar 1.ABSTRACTA diastereomeric mixture of racemic 3-phthalimido-b-lactam 2a/2b was synthesized by the Staudinger reaction of carboxylic acid activated with 2-chloro-1-methylpyridinium iodide and imine 1. The amino group at the C3 position of the b-lactam ring was used for further structural upgrade. trans-b-lactam ureas 4a-t were prepared by the condensation reaction of the amino group of b-lactam ring with various aromatic and aliphatic isocyanates. Antimicrobial activity of compounds 4a-t was evaluated in vitro and neither antibacterial nor anti...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Mladenka Jurin Vi šnja Stepanić Krunoslav Bojani ć Denis Vadlja Darko Kontrec Tonko Dra žić Marin Roje Source Type: research
Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model
Acta Pharm. 2024 Mar 30;74(1):117-130. doi: 10.2478/acph-2024-0001. Print 2024 Mar 1.ABSTRACTStatin treatment may increase the risk of diabetes; there is insufficient data on how statins affect glucose regulation and glycemic control and the effects of statins on liver enzymes related to carbohydrate metabolism have not been fully studied. Therefore, we aimed to compare the effects of the statin derivatives, pravastatin, and rosuvastatin, on carbohydrate metabolism in an experimental diabetic rat model. Female Wistar albino rats were used and diabetes was induced by intraperitoneal injection of streptozotocin. Thereafter, ...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Hacer Kayhan Kaya Berjan Demirtas Beran Yokus Dilek Ayg ün Kesim Ezel Tasdemir Abdurrahman Sermet Source Type: research
Long non-coding RNA < em > TINCR < /em > suppresses growth and epithelial-mesenchymal transition by inhibiting Wnt/ < em > β < /em > -catenin signaling pathway in human pancreatic cancer PANC-1 cells: Insights from < em > in vitro < /em > and < em > in vivo < /em > studies
This study sheds light on the tumour-suppressive role of TINCR in PANC-1 cells and suggests its potential as a therapeutic target. These results shed light on the molecular mechanisms underlying the impact of TINCR on pancreatic cancer and offer promising opportunities for innovative therapeutic strategies to improve outcomes in this serious malignancy.PMID:38554384 | DOI:10.2478/acph-2024-0009 (Source: Acta Pharmaceutica)
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Yuan Wei Ping Zhu Source Type: research
A comprehensive overview of selective and novel fibroblast growth factor receptor inhibitors as a potential anticancer modality
Acta Pharm. 2024 Mar 30;74(1):1-36. doi: 10.2478/acph-2024-0005. Print 2024 Mar 1.ABSTRACTThe arrival of comprehensive genome sequencing has accelerated the understanding of genetically aberrant advanced cancers and target identification for possible cancer treatment. Fibroblast growth factor receptor (FGFR) gene alterations are frequent findings in various rare and advanced cancers refractive to mainstay chemo-therapy or surgical interventions. Several FGFR inhibitors have been developed for addressing these genetically altered FGFR-harboring malignancies, and some have performed well in clinical trials. In contrast, othe...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Nem Kumar Jain Mukul Tailang Neelaveni Thangavel Hafiz A Makeen Mohammed Albratty Asim Najmi Hassan Ahmad Alhazmi Khalid Zoghebi Muthumanickam Alagusundaram Hemant Kumar Jain Balakumar Chandrasekaran Source Type: research
Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway
In conclusion, deguelin treatment, when applied in vitro, induced apoptotic cell death and resulted in mitotic cessation at the G2/M phase through modulation of cell cycle regulatory mRNAs in multiple myeloma cells.PMID:38554386 | DOI:10.2478/acph-2024-0003 (Source: Acta Pharmaceutica)
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Kening Sun Ping Chen Liang Zhang Zhidong Lu Qunhua Jin Source Type: research
Medicarpin suppresses lung cancer cell growth < em > in vitro < /em > and < em > in vivo < /em > by inducing cell apoptosis
This study was de sig ned to evaluate the anti-LC effect and reveal the underlying mechanisms of MED in vivo and in vitro. We found that MED could significantly inhibit proliferation, induce apoptosis, and cell cycle arrest of A549 and H157 cell lines. Basically, MED induced cell apoptosis of LC cells by upregu lating the expression of pro-apoptotic proteins BAX and Bak1, leading to the cleavage of caspase-3 (Casp3). Moreover, MED inhibited the proliferation of LC cells via downregulating the expression of proliferative protein Bid. Overall, MED inhibited LC cell growth in vitro and in vivo via suppressing cell proliferati...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Zongyi Shen Liqi Yin Manxia Chang Haifeng Wang Mingxuan Hao Youfeng Liang Rui Guo Ying Bi Jiansong Wang Changyuan Yu Jinmei Li Qiongli Zhai Runfen Cheng Jinku Zhang Jirui Sun Zhao Yang Source Type: research
Chemical composition and potential antioxidant, anti-inflammatory, and analgesic efficacy of < em > Cistus albidus < /em > L
This study aims to assess the chemical composition of the aqueous extract of Cistus albidus L. leaves, as well as the potential of aqueous and hydroethanol extracts of the leaves and seeds as analgesic, anti--inflammatory, and antioxidant agents. The contents of phenolics and inorganic constituents were determined in C. albidus seeds and leaves; antioxidant capacity was assessed by 3 complementary and diverse tests. The carrageenan-induced paw edema technique was used to investigate the anti-inflammatory effect in vivo, and albumin denaturation to evaluate the anti-inflammatory effect in vitro. The acetic acid-induced cont...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Aziz Zouhri Toufik Bouddine Naoual El Menyiy Yahya El-Mernissi Hassan Laaroussi Mohamed Chebaibi Hassan Amhamdi Abdelhay Elharrak Hiba-Allah Nafidi Baye Sitotaw Yousef A Bin Jardan Mohammed Bourhia Lhoussain Hajji Source Type: research
Effects of epidurally administered dexmedetomidine and dexamethasone on postoperative pain, analgesic requirements, inflammation, and oxidative stress in thoracic surgery
Acta Pharm. 2023 Dec 26;73(4):691-708. doi: 10.2478/acph-2023-0040. Print 2023 Dec 1.ABSTRACTThe aim of this study was to compare the effects of dexmedetomidine and dexamethasone as adjuvants to preoperative epidural administration of local anesthetic (ropivacaine) in thoracic surgery on the postoperative level of pain, use of analgesics, inflammation, and oxidative stress. The study enrolled 42 patients who underwent elective thoracic surgery in a one-year period at the University Hospital Dubrava (Zagreb, Croatia). Based on a computer-generated randomization list the patients were assigned to the dexmedetomidine (n = 18)...
Source: Acta Pharmaceutica - December 26, 2023 Category: Drugs & Pharmacology Authors: Jasminka Per šec Andrej Šribar Monika Ili ć Ivan Mami ć Domagoj Kifer Ana-Marija Domijan Željan Maleš Petra Tur čić Source Type: research
Azithromycin-loaded liposomal hydrogel: a step forward for enhanced treatment of MRSA-related skin infections
Acta Pharm. 2023 Dec 26;73(4):559-579. doi: 10.2478/acph-2023-0042. Print 2023 Dec 1.ABSTRACTAzithromycin (AZT) encapsulated into various types of liposomes (AZT-liposomes) displayed pronounced in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA) (1). The present study represents a follow-up to this previous work, attempting to further explore the anti-MRSA potential of AZT-liposomes when incorporated into chitosan hydrogel (CHG). Incorporation of AZT-liposomes into CHG (liposomal CHGs) was intended to ensure proper viscosity and texture properties of the formulation, modification of antibiotic rele...
Source: Acta Pharmaceutica - December 26, 2023 Category: Drugs & Pharmacology Authors: Zora Rukavina May Wenche J øraholmen Dunja Bo žić Ivana Frankol Petra Golja Ga šparović Nata ša Škalko-Basnet Maja Šegvić Klarić Željka Vanić Source Type: research
Simultaneous determination of macrolides in water samples by solid-phase extraction and capillary electrophoresis
Acta Pharm. 2023 Dec 26;73(4):515-535. doi: 10.2478/acph-2023-0041. Print 2023 Dec 1.ABSTRACTSolid-phase extraction (SPE) coupled with capillary electrophoresis (CE) for the determination of macrolide antibiotics (azithromycin, clarithromycin, roxithromycin, tylosin) and tiamulin in water samples was described in this article. These compounds were extracted with different types of sorbents ( Oasis HLB, C18, C8, SDB, and Strata-X) and different masses of sorbents (60 mg, 200 mg, and 500 mg) using different organic solvents (methanol, ethanol, and acetonitrile) and different pH values of water samples (pH 7.00, 8.00, and 9.0...
Source: Acta Pharmaceutica - December 26, 2023 Category: Drugs & Pharmacology Authors: Dragana Mutavd žić Pavlović Sandra Babi ć Mirta Čizmić Miranda Serti ć Tea Pinu šić Source Type: research
