Dendritic arbor dynamics and stability in health and disease
We describe the dynamic changes during development and adulthood and in different pathologies. Whenever possible, we also provide details on the molecular mechanisms behind dendritic dynamics and stability.PMID:38224286 | DOI:10.55782/ane-2023-2456 (Source: Acta Neurobiologiae Experimentalis)
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Magdalena Mlostek Juan Zeng Malgorzata Urbanska Jacek Jaworski Source Type: research
Pylabianca: comprehensive and user ‑friendly Python package for single‑neuron data analysis
Acta Neurobiol Exp (Wars). 2023 Dec 28;83(4):432-446. doi: 10.55782/ane-2023-2440.ABSTRACTIn the area of electrophysiology, the availability of comprehensive and user‑friendly tools for single-neuron data processing, statistical analysis, and fast, intuitive data visualization is limited. To address this gap, we introduce pylabianca, a Python library tailored for robust single and multi‑unit data processing. Pylabianca leverages the power of standard Python packages and adopts the application programming interface of MNE‑Python, one of the most widely used electrophysiology packages. One of pylabianca's primary objec...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Miko łaj Magnuski W ładysław Średniawa Katarzyna Paluch Davor Ivanovski Harish Babu Jan Kaminski Source Type: research
Glymphatic system and aquaporin ‑4 in epilepsy
Acta Neurobiol Exp (Wars). 2023 Dec 29;83(4):447-458. doi: 10.55782/ane-2023-2498.ABSTRACTOver the past decade glymphatic concept has gained more and more interest. Despite some lacking data regarding structural and functional aspects, glymphatic system is widely considered the main mechanism of water and solutes transport in brain parenchyma, as well as waste clearance from the brain. Glymphatic system modulates the extracellular space volume and is involved in spatial K+ buffering (via influencing Kir4.1 channel functioning), two factors crucial for neuronal excitability and seizure susceptibility, and is itself strongly...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Dorota Nowicka Source Type: research
Molecular mechanisms and treatment strategies for methamphetamine ‑induced neurodegeneration, inflammation and neurotoxicity
Acta Neurobiol Exp (Wars). 2023 Dec 28;83(4):414-431. doi: 10.55782/ane-2023-2488.ABSTRACTMethamphetamine (METH) is a highly addictive psychostimulant known for its profound impact on the nervous system. Chronic METH use leads to neurotoxicity characterized by various molecular and structural alterations in the brain. This review article primarily aims to elucidate the mechanisms underlying METH‑induced neurotoxicity. METH's mechanism of action involves the inhibition of dopamine, serotonin, and norepinephrine reuptake, resulting in altered synaptic function. Prolonged METH exposure triggers oxidative stress, endoplasmic...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Samareh Omidvari Zahra Azimzadeh Fariborz Rashnoo Foozhan Tahmasebinia Aliasghar Keramatinia Navid Ahmady Roozbahany Hojjat Allah Abbaszadeh Shahram Darabi Source Type: research
Early development of the Tsc1 Purkinje cell specific mouse knockouts
Acta Neurobiol Exp (Wars). 2023 Dec 12;83(4):404-413. doi: 10.55782/ane-2023-2472.ABSTRACTTsc1 is a gene which expression results in hamartin, a protein involved in regulation of the mTOR1 pathway. Inactivation of Tsc1 gives rise to hyperactivation of the mTOR1 machinery, increased proliferation and growth of cells with subsequent cell degeneration and cell death. In humans, mutations of Tsc1 result in an inherited disorder ‑ tuberous sclerosis complex (TSC) with the concomitant multiorgan non‑malignant tumors (tubers), epileptic seizures and autistic‑like manifestations. General mouse knock‑outs, homozygous for th...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Anna S ługocka Marta Anna Przyby ła Jaros ław Jerzy Barski Source Type: research
