Effect of levetiracetam on DNA oxidation and glutathione content in a temporal lobe epilepsy model
Acta Neurobiol Exp (Wars). 2024 Mar 28;84(1):51-58. doi: 10.55782/ane-2024-2537.ABSTRACTLevetiracetam (LEV) is a drug commonly used as an anticonvulsant. However, recent evidence points to a possible role as an antioxidant. We previously demonstrated the antioxidant properties of LEV by significantly increasing catalase and superoxide dismutase activities and decreasing the hydrogen peroxide (H2O2) levels in the hippocampus of rats with temporal lobe epilepsy (TLE) showing scavenging properties against the hydroxyl radical. The aim of the present work was to evaluate, the effect of LEV on DNA oxidation, by determining 8‑...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Itzel Jatziri Contreras-Garc ía Cindy Bandala Iv án Ignacio-Mejía Luz Adriana Pichardo-Mac ías Julieta Griselda Mendoza-Torreblanca Mercedes Edna Garc ía-Cruz Sa úl Gómez-Manzo Noem í Cárdenas-Rodríguez Source Type: research
Abnormal expression of long non ‑coding RNA LINC01270 in glioma and its correlation with X‑ray computed tomography signs
This study focused on the association of LINC01270 and computed tomography (CT) signs with glioma development, to evaluate their potential in the early detection of glioma. Serum LINC01270 was evaluated in glioma patients and healthy individuals using PCR. The involvement of LINC01270 in glioma onset and development was evaluated by ROC and chi‑square test. The association of LINC01270 with the CT signs and their combined effects in the diagnosis in glioma were also estimated. Serum LINC01270 was significantly elevated in glioma patients, which was closely associated with patients' advanced WHO grades and lower KPS. Both...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Ying Liu Yuntao Zhang Yongjun E Xianglin Zhang Heji Ma Furen Dong Source Type: research
Alarin potentiates ongoing epileptiform activity in rat brain slices: an in vitro electrophysiological study
In this study, we investigated if alarin induced any synchronous discharges or epileptiform activity, and if it had any effect on already initiated epileptiform discharges. We used thick acute horizontal hippocampal slices obtained from 30‑ to 35‑day‑old rats. Extracellular field potential recordings were evaluated in the CA1 region of the hippocampus. Our data demonstrated that, alarin application did not result in any epileptiform activity or abnormal discharges. 4‑aminopyridine was applied to induce epileptiform activity in the slices. We found that alarin increased the frequency of interictal‑like events and ...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Ömer Faruk Kalkan Hilal Öztürk Zafer Şahin Harun Ba şoğlu Selcen Aydin Abidin İsmail Abidin Source Type: research
Effects of morphine on conditioned place preference and pain are independent of uptake ‑2
This study was done to assess the effect of uptake‑2 inhibition on morphine‑induced conditioned place preference (CPP) and analgesia. In this study, the effects of morphine and/or D22 on CPP were evaluated following intraperitoneal injection in mice. Afterward, changes in motor activity were evaluated by the open field test. Using the tail‑flick model, the effects of D22 and/or morphine were evaluated on the pain threshold. The results showed that 20 mg/kg of morphine induced a place preference response. D22, at the dose of 0.03 mg/kg, caused place avoidance, while at the dose of 0.3 mg/kg, it produced a notable plac...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Mohammad Saeid Souri Mohaddeseh Sadat Alavi Ali Ahmadian Salami Ali Roohbakhsh Source Type: research
Optical imaging of the intrinsic signal as a tool to characterize orientation sensitivity in the primary visual cortex of the young mouse
Acta Neurobiol Exp (Wars). 2024 Mar 28;84(1):1-25. doi: 10.55782/ane-2024-2397.ABSTRACTWe employed intrinsic signal optical imaging (ISOI) to investigate orientation sensitivity bias in the visual cortex of young mice. Optical signals were recorded in response to the moving light gratings stimulating ipsi‑, contra‑ and binocular eye inputs. ISOI allowed visualization of cortical areas activated by gratings of specific orientation and temporal changes of light scatter during visual stimulation. These results confirmed ISOI as a reliable technique for imaging the activity of large populations of neurons in the mouse visu...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Ida Raciborska Piotr Dzwiniel Katarzyna Kordecka Anna Pos łuszny Wioletta Waleszczyk Andrzej Wr óbel Source Type: research
Glymphatic system and aquaporin ‑4 in epilepsy
Acta Neurobiol Exp (Wars). 2023 Dec 29;83(4):447-458. doi: 10.55782/ane-2023-2498.ABSTRACTOver the past decade glymphatic concept has gained more and more interest. Despite some lacking data regarding structural and functional aspects, glymphatic system is widely considered the main mechanism of water and solutes transport in brain parenchyma, as well as waste clearance from the brain. Glymphatic system modulates the extracellular space volume and is involved in spatial K+ buffering (via influencing Kir4.1 channel functioning), two factors crucial for neuronal excitability and seizure susceptibility, and is itself strongly...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Dorota Nowicka Source Type: research
Molecular mechanisms and treatment strategies for methamphetamine ‑induced neurodegeneration, inflammation and neurotoxicity
Acta Neurobiol Exp (Wars). 2023 Dec 28;83(4):414-431. doi: 10.55782/ane-2023-2488.ABSTRACTMethamphetamine (METH) is a highly addictive psychostimulant known for its profound impact on the nervous system. Chronic METH use leads to neurotoxicity characterized by various molecular and structural alterations in the brain. This review article primarily aims to elucidate the mechanisms underlying METH‑induced neurotoxicity. METH's mechanism of action involves the inhibition of dopamine, serotonin, and norepinephrine reuptake, resulting in altered synaptic function. Prolonged METH exposure triggers oxidative stress, endoplasmic...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Samareh Omidvari Zahra Azimzadeh Fariborz Rashnoo Foozhan Tahmasebinia Aliasghar Keramatinia Navid Ahmady Roozbahany Hojjat Allah Abbaszadeh Shahram Darabi Source Type: research
Early development of the Tsc1 Purkinje cell specific mouse knockouts
Acta Neurobiol Exp (Wars). 2023 Dec 12;83(4):404-413. doi: 10.55782/ane-2023-2472.ABSTRACTTsc1 is a gene which expression results in hamartin, a protein involved in regulation of the mTOR1 pathway. Inactivation of Tsc1 gives rise to hyperactivation of the mTOR1 machinery, increased proliferation and growth of cells with subsequent cell degeneration and cell death. In humans, mutations of Tsc1 result in an inherited disorder ‑ tuberous sclerosis complex (TSC) with the concomitant multiorgan non‑malignant tumors (tubers), epileptic seizures and autistic‑like manifestations. General mouse knock‑outs, homozygous for th...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Anna S ługocka Marta Anna Przyby ła Jaros ław Jerzy Barski Source Type: research
Effect of low ‑frequency repetitive transcranial magnetic stimulation on cognitive function in rats with medial temporal lobe epilepsy
Acta Neurobiol Exp (Wars). 2023 Dec 11;83(4):395-403. doi: 10.55782/ane-2023-2471.ABSTRACTEpilepsy, especially the medial temporal lobe epilepsy (TLE), can result in cognitive impairment. Low‑frequency repetitive magnetic stimulation (rTMS) has been verified to suppress neural excitability and reduce seizures. Given its potential in modifying cortical activity, we aimed to investigate its impact on cognitive function in the context of epilepsy, a condition where the use of rTMS has not been extensively explored. However, the influence on cognitive function has not yet been investigated. Therefore, this study aimed to inv...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Li-Qin Che Zhen-Zhen Qu Tao Xie Yan-Ge Zhang Dong-Juan Yuan Qing Li Li-Jing Jia Wei-Ping Wang Source Type: research
Systematic review and meta ‑analysis of observational studies to check the protective role of non‑steroidal anti‑inflammatory drugs in Alzheimer's disease
Acta Neurobiol Exp (Wars). 2023 Dec 4;83(4):386-394. doi: 10.55782/ane-2023-2467.ABSTRACTAlzheimer's disease (AD) is a major neurodegenerative disease, affecting more than two third cases of dementia in the world. Non‑steroidal anti‑inflammatory drugs (NSAIDs) are widely used anti‑inflammatory analgesic agents representing 7.7% of worldwide prescriptions of which 90% are in patients over 65 years old. Based on mixed findings a systematic review and meta‑analysis were conducted to develop a better understanding of the protective role of NSAIDs in AD. We used three database PubMed, Web of Science, and Embase to ident...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Akash Asthana Shashank Tripathi Rachna Agarwal Source Type: research
The protective role of circ_0016760 downregulation against sevoflurane ‑induced neurological impairment via modulating miR‑145 expression in aged rats
This study focused on the effect of circ_0016760 on sevoflurane‑induced neurological impairment. The GEO database (GSE147277) and RT‑qPCR were used to predict and measure the circ_0016760 expression. The interaction of circ_0016760 and miR‑145 was verified by dual‑luciferase reporter assay. The CCK‑8 assay, flow cytometry, ELISA, ROS kit, MWM test were carried out to measure the cell viability, apoptosis, inflammation indicators, ROS level, and cognitive and memory function of the rats. Sevoflurane exacerbated neurotoxicity by restraining cell viability, inducing cell apoptosis, neuroinflammation, and ROS generat...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Peiyu Shuai Zhihong Hu Wei Li Guoliang You Zhiye Liu Niandong Zheng Source Type: research
The less complex temporal patterns of resting ‑state EEG activity, the lower the visual temporal order threshold
Acta Neurobiol Exp (Wars). 2023 Nov 30;83(4):359-376. doi: 10.55782/ane-2023-2463.ABSTRACTSpeech understanding, watching a movie, listening to music etc., requires perception of the temporal order of at least two incoming events. A history of performing these tasks may be reflected in spontaneous brain activity. Here, we examined the relationship between the complexity (temporal dynamics) of resting‑state EEG (rsEEG) signal, assessed using the multivariate MultiScale Entropy (mMSE) algorithm, and the perception of event ordering, indexed by a visual temporal order threshold (TOT), i.e., the minimum duration necessary to ...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Monika Lewandowska Krzysztof To łpa Marcin Hajnowski Tomasz Piotrowski Joanna Dreszer Source Type: research
Dendritic arbor dynamics and stability in health and disease
We describe the dynamic changes during development and adulthood and in different pathologies. Whenever possible, we also provide details on the molecular mechanisms behind dendritic dynamics and stability.PMID:38224286 | DOI:10.55782/ane-2023-2456 (Source: Acta Neurobiologiae Experimentalis)
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Magdalena Mlostek Juan Zeng Malgorzata Urbanska Jacek Jaworski Source Type: research
Pylabianca: comprehensive and user ‑friendly Python package for single‑neuron data analysis
Acta Neurobiol Exp (Wars). 2023 Dec 28;83(4):432-446. doi: 10.55782/ane-2023-2440.ABSTRACTIn the area of electrophysiology, the availability of comprehensive and user‑friendly tools for single-neuron data processing, statistical analysis, and fast, intuitive data visualization is limited. To address this gap, we introduce pylabianca, a Python library tailored for robust single and multi‑unit data processing. Pylabianca leverages the power of standard Python packages and adopts the application programming interface of MNE‑Python, one of the most widely used electrophysiology packages. One of pylabianca's primary objec...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Miko łaj Magnuski W ładysław Średniawa Katarzyna Paluch Davor Ivanovski Harish Babu Jan Kaminski Source Type: research
Glymphatic system and aquaporin ‑4 in epilepsy
Acta Neurobiol Exp (Wars). 2023 Dec 29;83(4):447-458. doi: 10.55782/ane-2023-2498.ABSTRACTOver the past decade glymphatic concept has gained more and more interest. Despite some lacking data regarding structural and functional aspects, glymphatic system is widely considered the main mechanism of water and solutes transport in brain parenchyma, as well as waste clearance from the brain. Glymphatic system modulates the extracellular space volume and is involved in spatial K+ buffering (via influencing Kir4.1 channel functioning), two factors crucial for neuronal excitability and seizure susceptibility, and is itself strongly...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Dorota Nowicka Source Type: research
