Evaluating Diuretics in Normal Care (EVIDENCE): protocol of a cluster randomised controlled equivalence trial of prescribing policy to compare the effectiveness of thiazide-type diuretics in hypertension
We describe an approach to rapidly generate externally valid evidence of comparative safety and effectiveness using the example of two widely used diuretics for the management of hypertension.Methods and analysisThe EVIDENCE (Evaluating Diuretics in Normal Care) study has a prospective, cluster-randomised, open-label, blinded end-point design. By randomising prescribing policy in primary care practices, the study compares the safety and effectiveness of commonly used diuretics in treating hypertension. Participating practices are randomised 1:1 to a policy of prescribing either indapamide or bendroflumethiazide when clinic...
Source: Trials - November 17, 2021 Category: Research Source Type: clinical trials
Efficacy and Safety Study of the Fixed-dose Combination of Olmesartan + Indapamide When Compared to the Isolated Drugs in the Treatment of Hypertension.
Conditions: Hypertension; Hypertension,Essential Interventions: Drug: fixed-dose of olmesartan 20mg/40 mg + indapamide 1,5 mg; Drug: Isolated drugs Olmesartan (20 mg or 40 mg) and Indapamide (1,5 mg) Sponsor: Brainfarma Industria Química e Farmacêutica S/A Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 8, 2021 Category: Research Source Type: clinical trials
Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)
Condition: Hypertension Interventions: Drug: Olmesartan; Drug: Amlodipine; Drug: Indapamide; Drug: Placebo; Drug: Zilebesiran Sponsor: Alnylam Pharmaceuticals Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 2, 2021 Category: Research Source Type: clinical trials
