Fight Aging! Newsletter, March 11th 2024
In conclusion, this Mendelian randomization study found that Streptococcus was causally associated with Bioage acceleration. Further randomized controlled trials are needed to investigate its role in the aging process.
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Considering the Mechanisms of Vascular Calcification
https://www.fightaging.org/archives/2024/03/considering-the-mechanisms-of-vascular-calcification/
Harmful calcification of structures in the cardiovascular system proceeds alongside the development of the fatty lesions of atherosclerosis. Both disease processes are accelerated by chronic inflammation, but d...
Source: Fight Aging! - March 10, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Request for Startups in the Rejuvenation Biotechnology Space, 2024 Edition
Investors focused on funding biotechnology startups tend to exhibit herd behavior, much like investors everywhere these days. Funding is primarily deployed towards fads and popular trends, not necessarily towards what makes the most sense, even if sometimes the sensible manages to align with the popular. These days that means drug discovery platforms with a strong computational component and partial epigenetic reprogramming. But even in this environment, the path to true success is to work on important projects that few other people are touching. Be the champion for a potential solution to a tough, high-value, comparativel...
Source: Fight Aging! - March 8, 2024 Category: Research Authors: Reason Tags: Investment Source Type: blogs
Title 42 Failed. It Should Not Be Extended in Any Form
David J. BierWith thesunsetting of the public health emergency this week, Border Patrol will lose its ability to expel some immigrants at the border under Title 42. Under Title 42, Border Patrol could quickly remove someone from the United States, sending them back to Mexico or, in some cases, their home country without allowing them the ability to request asylum in the United States. President Biden ’s plan to replace Title 42 involves more legal immigration andan asylum ban for those who cross illegally paired with deportations to Mexico for eight nationalities.Title 42 has failed on its own terms. Crossings have incre...
Source: Cato-at-liberty - May 10, 2023 Category: American Health Authors: David J. Bier Source Type: blogs
Title 42 Failed. It Should Not Be Extended in Any Form.
David J. BierWith thesunsetting of the public health emergency this week, Border Patrol will lose its ability to expel some immigrants at the border under Title 42. Under Title 42, Border Patrol could quickly remove someone from the United States, sending them back to Mexico or, in some cases, their home country without allowing them the ability to request asylum in the United States. President Biden ’s plan to replace Title 42 involves more legal immigration andan asylum ban for those who cross illegally paired with deportations to Mexico for eight nationalities.Title 42 has failed on its own terms. Crossings have incre...
Source: Cato-at-liberty - May 10, 2023 Category: American Health Authors: David J. Bier Source Type: blogs
Biden ’s Border Immigration Policy Is Still Reducing Border Crossings and Illegal Immigration
Alex NowrastehFrom December 2022 to February 2023, encounters of migrants crossing the southwest (SW) border with Mexico are down 39 percent. President Biden ’s immigration and borderplan that expanded legal migration to the United States through humanitarian parole should take credit for this decline. Under Biden ’s plan, up to 30,000 migrants from Venezuela, Cuba, Nicaragua, and Haiti (VCNH migrants) are allowed to enter the United States legally each month through humanitarian parole. As a result, more of them are waiting to come legally rather than attempting to cross illegally.In February 2023, the number of VCNH...
Source: Cato-at-liberty - March 29, 2023 Category: American Health Authors: Alex Nowrasteh Source Type: blogs
Immigrating to the U.S. Is The Main Way To Escape Poverty in Dozens of Countries
David J. BierImmigrating to the United States is the main way to escape poverty in many countries. For about 3 dozen countries, most of their not‐in‐poverty population lives in the United States. Indeed, under the developed world poverty standard of $30 per day, immigration is just about the only way to escape poverty for several nationalities. Since poverty is practically assured in their home c ountries, it should not surprise lawmakers that millions of people would risk everything to immigrate to the United States.In 2019, only about 16 percent of people in the United Stateslived below the $30‐per‐...
Source: Cato-at-liberty - February 21, 2023 Category: American Health Authors: David J. Bier Source Type: blogs
Fight Aging! Newsletter, February 20th 2023
In this study, researchers stimulate the ghrelin receptor using a suitable small molecule for much of the lifespan of mice, and observe the results. The overall extension of life span is a quarter of that produced by calorie restriction, and so we might draw some conclusions from that as to the relative importance of hunger in the benefits resulting from the practice of calorie restriction or fasting. Interestingly, the short term weight gains observed in mice given this ghrelin receptor agonist in the past don't appear in this long term study, in which the controls are the heaver animals. This is possibly because the rese...
Source: Fight Aging! - February 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Shabby Pop-Sci Article on the Minicircle Trial of Follistatin Gene Therapy
Minicircle is working towards the upregulation of follistatin, an inhibitor of myostatin and thus an interesting target for improved muscle growth and treatment of sarcopenia. Follistatin and myostatin are well studied genes in this context, and there are any number of animal studies, as well as human trials of various approaches to myostatin inhibition. As I have long said, follistatin and myostatin are probably the most compelling, least risky genes to start working on if interested in gene therapy development. There is a great deal of animal and human data to support this work.
It is always annoying to see shabbi...
Source: Fight Aging! - February 14, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Title 42 ’s End Won’t Affect Most Border Crossers
David J. BierThe U.S. Border Patrolcould soon lose its novel authority to expel border crossers back into Mexico under Title 42 of the U.S. code, a 19th century public health law never previously used to remove people from the United States. Since March 2020, the agency has used Title 42 to ignore the normal process to which crossers are entitled under Title 8 of the U.S. immigration code and force them back into Mexico often within a few minutes of their arrests. The government is also flying some migrants directly back to their home countries under the rule.Figure 1 shows the number of border arrests by processing type: ...
Source: Cato-at-liberty - December 20, 2022 Category: American Health Authors: David J. Bier Source Type: blogs
CBP Is Expelling Thousands of Infants and Toddlers to Mexico After Midnight
David J. BierAt 1 a.m. they left us at the bridge in Juárez. I asked them why they would throw us to the streets at night with children, and an agent said, ‘That’s your problem, that is not my problem.’-35 ‐year‐old man from Honduras (interviewed by Physicians for Human Rights)In the dead of night, Customs and Border Protection (CBP) is expelling thousands of immigrant infants and toddlers into Mexican border cities that the U.S. State Department saysare too dangerous for American tourists. New statistics obtained via a Cato Freedom of Information Act request show that as of May 31, CBP had used its T...
Source: Cato-at-liberty - August 1, 2022 Category: American Health Authors: David J. Bier Source Type: blogs
Congress Should Require TPS for Immigrants from Nations With Armed Conflicts
David J. BierSince 1990, the executive branch has had the authority from Congress to provide Temporary Protected Status (TPS) to people already in the United States who are from countries in which an “ongoing armed conflict within the state" exists. A bipartisan group in Congress wrote a letter to the Biden administration requesting that it designate Ukraine for TPS, and then they also proposed legislation torequire it to use its authority.Finally, the administrationhas relented (with the full details still to be filled in). But Congress should still recognize the procedural problem with giving total discretion to th...
Source: Cato-at-liberty - March 4, 2022 Category: American Health Authors: David J. Bier Source Type: blogs
Biden ’s Border Policy Is Not “Open Borders”
David J. BierPractically since his first week in office, President Joe Biden has faced repeated criticisms from Republicans and someDemocrats that his border policy amounts to “open borders.” This criticism is not simply inaccurate: it isunhingedfrom reality in a way that distinguishes itself from normal political hyperbole. Indeed, U.S. immigration policy is effectivelyclosed borders, and Biden ’s immigration policies and goals are largely the same as those of President Donald Trump.Under U.S. immigration law, it is illegal for anyone in the world to travel or immigrate to the United States unless they fall into ver...
Source: Cato-at-liberty - September 23, 2021 Category: American Health Authors: David J. Bier Source Type: blogs
House 2022 National Defense Authorization Act Amendments on Arms Sales and Security Assistance
Jordan CohenThe House is set to vote on theNational Defense Authorization Act (NDAA) for fiscal year 2022. Prior to the structured Rule for the act, there were a total of fifty amendments that, if passed, would directly impact weapons sales legislation. Overall, these bills are divided into five broad themes: congressional power, increased monitoring and reporting surrounding human rights violators, weapons sales to the Middle East, weapons sales to counter Russia, and weapons sales to counter China.Readers should examine the2020 Arms Sales Risk Index for our latest data on risks associated with the weapons sales proc...
Source: Cato-at-liberty - September 21, 2021 Category: American Health Authors: Jordan Cohen Source Type: blogs
Central American Illegal Migration Tracks US Job Openings, Mexican Illegal Migration Tracks Visas
David J. BierThe U.S. Border Patrol could arrest as many immigrants from Central America ’s Northern Triangle of El Salvador, Guatemala, and Honduras this year than any year in its history. Several causes have combined to create this historic migration, but one that has received little attention so far is the state of the U.S. economy. Contrary to the perception that the labor market is doing poorly, U.S. employers actuallyhad more unfilled positions in February of 2021 (seasonally adjusted) than in February of 2020 before the pandemic.U.S. employers need workers, and Central Americans are helping fill those positions. I...
Source: Cato-at-liberty - May 3, 2021 Category: American Health Authors: David J. Bier Source Type: blogs
DHS Should Release Supplemental H-2B Visas Immediately
David J. BierLast year, Congressauthorized the Department of Homeland Security (DHS) to effectively double this year ’s H-2B visa cap fornonagricultural seasonal employers in landscaping, forestry, seafood, and other industries. Employer requests exceed the initial cap onFebruary 12, but in over two weeks, DHS has announced no plans to release any additional visas. This failure compounds President Biden ’s ongoing error of not rescindingDonald Trump ’s H-2B visa ban on some types of H-2B workers.Employers will need their workers by April 1, so the administration has barely one month to notify employers of the new pro...
Source: Cato-at-liberty - March 1, 2021 Category: American Health Authors: David J. Bier Source Type: blogs
