Metabolic engineering of Escherichia coli for efficient production of L-arginine
Appl Microbiol Biotechnol. 2022 Aug 6. doi: 10.1007/s00253-022-12109-4. Online ahead of print.ABSTRACTAs an important semi-essential amino acid, L-arginine (L-Arg) has important application prospects in medicine and health care. However, it remains a challenge to efficiently produce L-Arg by Escherichia coli (E. coli). In the present study, we obtained an E. coli A1 with L-Arg accumulation ability, and carried out a series of metabolic engineering on it, and finally obtained an E. coli strain A7 with high L-Arg production ability. First, genome analysis of strain A1 was performed to explore the related genes affecting L-Ar...
Source: Applied Microbiology and Biotechnology - August 5, 2022 Category: Microbiology Authors: Hai-De Wang Jian-Zhong Xu Wei-Guo Zhang Source Type: research

The COVID-19 pandemic and birth outcomes in 2020: The role of prenatal care and other channels
Econ Hum Biol. 2022 Jul 30;47:101167. doi: 10.1016/j.ehb.2022.101167. Online ahead of print.ABSTRACTWe use national birth data to assess the associations between the COVID-19 pandemic during 2020 and birth outcomes in Uruguay. Employing interrupted time series difference-in-differences techniques, we find mixed results, with some pregnancies showing increases in the likelihood of very preterm or very-low-weight births, and some others showing decreases in the incidence of moderate prematurity and moderate low birth weight. Adverse outcomes are more likely among women with low education, women with previous children, and wi...
Source: Economics and Human Biology - August 5, 2022 Category: Biology Authors: Ana I Balsa Patricia Triunfo Source Type: research

Just a question of time? Explaining non-take-up of a public health insurance program designed for undocumented immigrants living in France
Health Econ Policy Law. 2022 Aug 5:1-17. doi: 10.1017/S1744133122000159. Online ahead of print.ABSTRACTState Medical Aid is a public health insurance program that allows undocumented immigrants with low financial resources to access health care services for free. However, the low take-up rate of this program might threaten its efficiency. The purpose of this study is therefore to provide the determinants of such a low take-up rate. To this end, we rely on the Premier Pas survey. This is an original representative sample of undocumented immigrants attending places of assistance to vulnerable populations in France. Determina...
Source: Health Economics, Policy, and Law - August 5, 2022 Category: Health Management Authors: P Dourgnon F Jusot A Marsaudon J Sarhiri J Wittwer Source Type: research

Epidemiology, diagnostics and outcomes of acute occlusive arterial mesenteric ischaemia - a population-based study
CONCLUSIONS: Significant proportion of patients with AMI are not diagnosed alive, which is reflected in the mortality rates. Post-mortem examinations and autopsy rate data continue to be key factors in epidemiological studies on AMI.PMID:35931276 | DOI:10.1016/j.ejvs.2022.07.006 (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - August 5, 2022 Category: Surgery Authors: Aurora Lemma Matti Tolonen Pirkka Vikatmaa Panu Mentula Ilkka Kantonen Anna But Ari Lepp äniemi Ville Sallinen Source Type: research

Reflections on China's primary care response to COVID-19: roles, limitations and implications
This study focuses on the role of primary care in China's response to COVID-19. A retrospective, reflective approach was taken using data available to one of the authors who led the national community response to COVID-19, first in Wuhan and then multiple cities in ten provinces/municipalities across the country. At the peak of the pandemic, primary care providers shoulder various public health responsibilities and work in close partnerships with other key stakeholders in the local communities. Primary care providers keep playing a 'sentinel'/surveillance role in identifying re-emerging cases after the elimination of commu...
Source: Primary Care - August 5, 2022 Category: Primary Care Authors: Xiao Tan Chaojie Liu Hao Wu Source Type: research