Osteoclast-Cancer Cell Metabolic Crosstalk Confers PARP Inhibitor Resistance in Bone Metastatic Breast Cancer
Cancer Res. 2023 Dec 1. doi: 10.1158/0008-5472.CAN-23-1443. Online ahead of print.ABSTRACTThe majority of patients with late-stage breast cancer develop distal bone metastases. The bone microenvironment can affect response to therapy, and uncovering the underlying mechanisms could help identify improved strategies for treating bone metastatic breast cancer. Here, we observed that osteoclasts reduced the sensitivity of breast cancer cells to DNA damaging agents, including cisplatin and the PARP inhibitor (PARPi) olaparib. Metabolic profiling identified elevated glutamine production by osteoclasts. Glutamine supplementation ...
Source: Cell Research - December 1, 2023 Category: Cytology Authors: Huijuan Fan Zhanao Xu Ke Yao Bingxin Zheng Yuan Zhang Xuxiang Wang Tengjiang Zhang Xuan Li Haitian Hu Bin Yue Zeping Hu Hanqiu Zheng Source Type: research
Determinants of mental illness and care seeking behaviours in Northern Haiti: an assessment of demographic, social, and religio-cultural factors among patients at the first mental health clinic in the region
Ment Health Relig Cult. 2023;26(3):238-260. doi: 10.1080/13674676.2023.2202901. Epub 2023 Jul 24.ABSTRACTPopulations in countries such as Haiti demonstrate a high level of need for mental health care despite a lack of services and trained professionals. In addition to the dearth of biomedical services, local belief systems and explanatory models contribute to a majority of the population relying on traditional medicine as their first option for care. Using a mixed-methods approach, we aim to characterise mental illness at the first mental health clinic in the region - Sant Sante Mantal Mòn Pele (SSMMP) - by interviewing 9...
Source: Mental Health, Religion and Culture - December 1, 2023 Category: Psychiatry & Psychology Authors: Michael Galvin Guesly Michel Edny Pierre Eurine Manguira Carolyn Lesorogol Jean-Fran çois Trani Lora Iannotti Source Type: research
Osteoclast-Cancer Cell Metabolic Crosstalk Confers PARP Inhibitor Resistance in Bone Metastatic Breast Cancer
Cancer Res. 2023 Dec 1. doi: 10.1158/0008-5472.CAN-23-1443. Online ahead of print.ABSTRACTThe majority of patients with late-stage breast cancer develop distal bone metastases. The bone microenvironment can affect response to therapy, and uncovering the underlying mechanisms could help identify improved strategies for treating bone metastatic breast cancer. Here, we observed that osteoclasts reduced the sensitivity of breast cancer cells to DNA damaging agents, including cisplatin and the PARP inhibitor (PARPi) olaparib. Metabolic profiling identified elevated glutamine production by osteoclasts. Glutamine supplementation ...
Source: Cell Research - December 1, 2023 Category: Cytology Authors: Huijuan Fan Zhanao Xu Ke Yao Bingxin Zheng Yuan Zhang Xuxiang Wang Tengjiang Zhang Xuan Li Haitian Hu Bin Yue Zeping Hu Hanqiu Zheng Source Type: research
Determinants of mental illness and care seeking behaviours in Northern Haiti: an assessment of demographic, social, and religio-cultural factors among patients at the first mental health clinic in the region
Ment Health Relig Cult. 2023;26(3):238-260. doi: 10.1080/13674676.2023.2202901. Epub 2023 Jul 24.ABSTRACTPopulations in countries such as Haiti demonstrate a high level of need for mental health care despite a lack of services and trained professionals. In addition to the dearth of biomedical services, local belief systems and explanatory models contribute to a majority of the population relying on traditional medicine as their first option for care. Using a mixed-methods approach, we aim to characterise mental illness at the first mental health clinic in the region - Sant Sante Mantal Mòn Pele (SSMMP) - by interviewing 9...
Source: Mental Health, Religion and Culture - December 1, 2023 Category: Psychiatry & Psychology Authors: Michael Galvin Guesly Michel Edny Pierre Eurine Manguira Carolyn Lesorogol Jean-Fran çois Trani Lora Iannotti Source Type: research
