SMA-TB: study protocol for the phase 2b randomized double-blind, placebo-controlled trial to estimate the potential efficacy and safety of two repurposed drugs, acetylsalicylic acid and ibuprofen, for use as adjunct therapy added to, and compared with, the standard WHO recommended TB regimen
DiscussionSMA-TB will provide proof of concept of the HDT as a co-adjuvant treatment and identify the suitability of the intervention for different population groups (different epidemiological settings and drug susceptibility) in the reduction of tissue damage and risk of bad outcomes for TB patients. This regimen potentially will be more effective and targeted: organ saving, reducing tissue damage and thereby decreasing the length of treatment and sequelae, increasing cure rates and pathogen clearance and decreasing transmission rates. It will result in better clinical practice, care management and increased well-being of...
Source: Trials - June 28, 2023 Category: Research Source Type: clinical trials
CAR T-cell Therapy in Patients With Renal Dysfunction
Conditions: Non-hodgkin Lymphoma,B Cell; Multiple Myeloma; Acute Lymphoblastic Leukemia, Adult Interventions: Drug: Fludarabine; Drug: Cyclophosphamide Sponsors: Northside Hospital, Inc.; Blood and Marrow Transplant Group of Georgia Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - June 19, 2023 Category: Research Source Type: clinical trials
