Clinical trial registration during COVID-19 and beyond in the African context: what have we learned?
AbstractSince the outbreak of COVID-19, many lives have been impacted especially on the African continent which is already fighting the burden of multiple diseases of poverty. However, clinical research has offered hope for treatment and prevention options for this infectious disease. Despite many COVID-19 clinical trials conducted globally, three countries in Africa account for more than 80% of all trials from the continent registered trials in clinical trial registries. This indicates geographic disparity among COVID-19 research in Africa. From the perspective of clinical trial registration, transparency in clinical rese...
Source: Trials - June 6, 2022 Category: Research Source Type: clinical trials
How to embed qualitative research in trials: insights from the feasibility study of the SAFER trial programme
AbstractQualitative research can enhance the design, conduct and interpretation of trials. Despite this, few trials incorporate qualitative methods, and those that do may not realise their full potential. In this commentary, we highlight how qualitative research can contribute to the design, conduct and day-to-day running of a trial, outlining the working arrangements and relationships that facilitate these contributions. In doing so, we draw on (i) existing frameworks on the role of qualitative research alongside trials and (ii) our experience of integrated qualitative research conducted as part of the feasibility study o...
Source: Trials - May 12, 2022 Category: Research Source Type: clinical trials
Caries inhibition with CO2-laser during orthodontic treatment: a study protocol for a randomized split-mouth controlled clinical trial
AbstractIntroductionWhite spot lesions associated with orthodontic treatment are a common problem. Recent studies reported increased resistance to acid demineralization of enamel after sub-ablative CO2-laser irradiation in a combination with fluoride application. The aim of the study is to assess the efficacy of CO2-laser in combination with a fluoride varnish in the prevention, severity, and extent of white spot lesions during orthodontic treatment with fixed appliances.Methods and analysisThis is a protocol for a randomized, split-mouth controlled, clinical trial. The participants will be children aged 12 –18 years a...
Source: Trials - March 12, 2022 Category: Research Source Type: clinical trials
Ground-Breaking Electroporation-based Intervention for PAROXysmal Atrial Fibrillation Treatment (BEAT PAROX-AF)
Condition: Atrial Fibrillation Interventions: Device: PVI using PEF; Device: PVI using CFRF Sponsors: University Hospital, Bordeaux; Funding: European Commission (H2020) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 16, 2021 Category: Research Source Type: clinical trials
