A Phase 1 Study to Assess an Escalating Dose, Multi-prime Vaccination Schedule of R21/Matrix-M ™
Conditions: Malaria,Falciparum Interventions: Biological: R21/Matrix M ™ (Group 1); Biological: R21/Matrix M™ (Group 2); Biological: R21/Matrix M™ (Group 3); Procedure: Fine needle aspiration (FNA) Sponsors: University of Oxford; Bill and Melinda Gates Foundation; University Hospitals Bristol and Weston NHS Foundation Trust Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 20, 2024 Category: Research Source Type: clinical trials
The Role of tHyroid cAncer Specific Patient Concerns iNventory (PCI-TC) in Enhancing Shared decisiOn Making
Conditions: Thyroid Cancer Interventions: Other: Interview Sponsors: Royal Marsden NHS Foundation Trust; ENTUK Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 20, 2024 Category: Research Source Type: clinical trials
Occupational Therapy for Children and Young People Who Self-harm: A Qualitative Study
Conditions: Self Harm Interventions: Other: Occupational therapy Sponsors: Bournemouth University; Dorset HealthCare University NHS Foundation Trust Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 19, 2024 Category: Research Source Type: clinical trials
Exercise to Boost Immunity in Advanced Cancer
Conditions: Mesothelioma; Lung; Pancreatic Cancer Interventions: Other: Exercise Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; University of Sheffield; Sheffield Hallam University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2024 Category: Research Source Type: clinical trials
Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
Conditions: Arrhythmogenic Right Ventricular Cardiomyopathy Sponsors: Tenaya Therapeutics; University of California, San Francisco; Brigham and Women ' s Hospital; New York University; University of Colorado, Denver; Johns Hopkins University; The Cleveland Clinic; Mayo Clinic; Medical University of South Carolina; Hopital Louis Pradel; Istituti Clinici Scientifici Maugeri SpA; The Queen Elizabeth Hospital; St George ' s University Hospitals NHS Foundation Trust; Royal Brompton& Harefield NHS Foundation Trust; Barts& The London NHS Trust Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2024 Category: Research Source Type: clinical trials
Validation of Innovative Scheimpflug Topography Derived RGP Contact Lens Designs In Optometry Network
Conditions: Keratoconus Interventions: Device: The contact lens to be investigated in this study (Scheimpflug topography derived corneal RGP contact lens design). A CE (UKCA) marked class 2 medical devices. Sponsors: Moorfields Eye Hospital NHS Foundation Trust Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2024 Category: Research Source Type: clinical trials
Development of a Drill Guidance System to Aid Intra-operative Surgical Drilling
Conditions: Orthopaedic Surgery Interventions: Procedure: Drill Guidance System (DGS) Sponsors: Royal United Hospitals Bath NHS Foundation Trust; University of Bath; Great Western Hospitals NHS Foundation Trust Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 13, 2024 Category: Research Source Type: clinical trials
Trial of Mirtazapine for Depression in IBD
Conditions: Major Depressive Disorder; Inflammatory Bowel Diseases Interventions: Drug: Mirtazapine; Drug: Placebo Sponsors: King ' s College London; King ' s College Hospital NHS Trust; Imperial College London; London North West Healthcare NHS Trust; Imperial College Healthcare NHS Trust; Guy ' s and St Thomas ' NHS Foundation Trust Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 13, 2024 Category: Research Source Type: clinical trials
Computational Assessment of Bioprosthetic Aortic Valve Function
Conditions: CFD; Valve Heart Disease Interventions: Diagnostic Test: Computed Tomography, Magnetic Resonance Imaging Sponsors: Royal Brompton& Harefield NHS Foundation Trust; Edwards Lifesciences; Imperial College London Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 12, 2024 Category: Research Source Type: clinical trials
Feasibility of Measuring Vertical Perception in Acute Stroke
Conditions: Stroke Interventions: Diagnostic Test: Scale for Contraversive Pushing; Diagnostic Test: Catherine Bergego Scale; Diagnostic Test: Bucket Test Sponsors: University of Winchester; Hampshire Hospitals NHS Foundation Trust; University Hospitals Dorset NHS Foundation Trust Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 8, 2024 Category: Research Source Type: clinical trials
ADAPT-AST (Adaptive Antimicrobial Susceptibility Testing)
Conditions: Urinary Tract Infections Sponsors: Liverpool University Hospitals NHS Foundation Trust Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 7, 2024 Category: Research Source Type: clinical trials
Acceptability/Tolerance of Protein Substitutes in Tablet Form for the Dietary Management of Rare Aminoacidopathies
Conditions: Tyrosinemia, Type I; Tyrosinemia, Type II; Tyrosinemia, Type III; Alkaptonuria; Homocystine; Metabolic Disorder; MSUD (Maple Syrup Urine Disease) Interventions: Dietary Supplement: Zero minis (range of protein substitutes in tablet form) Sponsors: metaX Institut fuer Diatetik GmbH; Birmingham Women ' s and Children ' s NHS Foundation Trust; Great Ormond Street Hospital for Children NHS Foundation Trust Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 7, 2024 Category: Research Source Type: clinical trials
Red Light Ptosis Proof-of-Concept
Conditions: Mitochondrial Diseases; Blepharoptosis Interventions: Device: Near-infrared light Sponsors: University College, London; Moorfields Eye Hospital NHS Foundation Trust Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 5, 2024 Category: Research Source Type: clinical trials
Early Diagnosis of SSc in the General Rheumatology Clinic - Pilot
Conditions: Systemic Sclerosis; Raynaud Phenomenon Interventions: Device: Observation - Nailfold capillaroscopy Sponsors: University of Manchester; National Institute for Health Research, United Kingdom; Royal Bolton Hospital NHS Foundation Trust; Alder Hey Children ' s NHS Foundation Trust; University Hospitals of Morecambe Bay NHS Trust; Stockport NHS Foundation Trust; Medway NHS Foundation Trust; Northern Care Alliance NHS Foundation Trust; Royal Free Hospital NHS Foundation Trust Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 4, 2024 Category: Research Source Type: clinical trials
Solutions Trial: Solution Focused Brief Therapy (SFBT) in 10 –17-year-olds presenting at police custody: a randomised controlled trial
DiscussionThis two-arm individually RCT will evaluate the effectiveness of SFBT in reducing offending behaviours in CYP presenting at police custody suites within the area served by LSCFT. Our process evaluation will assess the fidelity of delivery of SFBT, the factors affecting implementation, the acceptability of SFBT in CYP aged 10 –17 years and recruitment and reach. We will also examine systems and structures for future delivery, therefore assessing overall scalability.Trial registrationClinicalTrials.gov ISRCTN14195235. Registered on June 16, 2023. (Source: Trials)
Source: Trials - March 2, 2024 Category: Research Source Type: clinical trials
