Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
