Empirical treatment against cytomegalovirus and tuberculosis in HIV-infected infants with severe pneumonia: study protocol for a multicenter, open-label randomized controlled clinical trial
DiscussionGiven the challenges in diagnosing CMV and TB in children and results from previous autopsy studies that show high rates of poly-infection in HIV-infected infants with respiratory disease, this study aims to evaluate a new approach including empirical treatment of CMV and TB for this patient population. The potential downsides of empirical treatment of these conditions include toxicity and medication interactions, which will be evaluated with pharmacokinetics sub-studies.Trial registrationClinicalTrials.gov, NCT03915366, Universal Trial Number U111-1231-4736, Pan African Clinical Trial Registry PACTR201994797961340. (Source: Trials)
Source: Trials - June 27, 2022 Category: Research Source Type: clinical trials
The Relationship Between CMV* Reactivation and Anti-cytokine Treatment in Critical COVID-19 Patients
Condition: COVID-19, Cytomegalovirus (CMV), Tocilizumab, Anakinra, Mortality Intervention: Diagnostic Test: CMV DNA analysis Sponsor: Ramazan Gozukucuk Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - June 15, 2022 Category: Research Source Type: clinical trials
