The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of {beta}-amyloid
Cerebral amyloid angiopathy (CAA) and β-amyloid (Aβ) deposition in the brain parenchyma are hallmarks of Alzheimer’s disease (AD). We previously reported that platelets contribute to Aβ aggregation in cerebral vessels by secreting the factor clusterin upon binding of Aβ40 to the fibrinogen receptor integrin αIIbβ3. Here, we investigated the contribution of the collagen receptor GPVI (glycoprotein VI) in platelet-induced amyloid aggregation. Using platelets isolated from GPVI–wild type and GPVI-deficient human donors and mice, we found that Aβ40 bound to GPVI, which induced th...
Source: Signal Transduction Knowledge Environment - August 3, 2020 Category: Science Authors: Donner, L., Toska, L. M., Krüger, I., Gröniger, S., Barroso, R., Burleigh, A., Mezzano, D., Pfeiler, S., Kelm, M., Gerdes, N., Watson, S. P., Sun, Y., Elvers, M. Tags: STKE Research Articles Source Type: news
FDA Slams Torrent Over Losartan Manufacturing Lapses FDA Slams Torrent Over Losartan Manufacturing Lapses
The company was cited for quality-control violations and other issues regarding its manufacture of losartan potassium tablets at one of its facilities in India.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - October 16, 2019 Category: Cardiology Tags: Cardiology News Source Type: news
Torrent Pharma recalls 74k bottles of hypertension drug from US
As per the report, Torrent Pharma Inc is recalling 17,088 bottles of Losartan Potassium /Hydrochlorothiazide tablets, USP 50mg/12.5mg from the same markets. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - October 12, 2019 Category: Pharmaceuticals Source Type: news
Medical News Today: More batches of common hypertension drug taken off the market
Torrent Pharmaceuticals Ltd. is withdrawing more batches of Losartan potassium tablets, USP and Losartan potassium/hydrochlorothiazide tablets, USP. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 27, 2019 Category: Consumer Health News Tags: Hypertension Source Type: news
More Blood Pressure Drugs Recalled
TUESDAY, Sept. 24, 2019 -- The recall of the commonly prescribed blood pressure drug losartan has been expanded once again to include an additional five lots.
The drug, made by Torrent Pharmaceuticals, has been recalled because some lots are... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 24, 2019 Category: Pharmaceuticals Source Type: news
FDA Expands Recall Of Blood Pressure Drugs Again
(CNN) — Torrent Pharmaceuticals Ltd. has expanded its voluntary recall of two blood pressure medications after trace amounts of a potentially cancer-causing impurity were found during testing.
The recall affects Losartan Potassium Tablets USP and Losartan Potassium/hydrochlorothiazide tablets.
Tests of some of those medications revealed amounts of N-methylnitrosobutyric acid (NMBA) that were above the US Food and Drug Administration’s daily acceptable levels.
This recall is related to the valsartan recall that has been expanded multiple times since July, when separate lots of blood pressure medications from dif...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - September 24, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Syndicated CBSN Boston CNN Recall Valsartan Source Type: news
Torrent Recalls More Tainted Losartan Torrent Recalls More Tainted Losartan
It ' s the fifth recall by Torrent of losartan-containing medicines due to detection of unacceptable levels of a potential carcinogen.News Alerts (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - September 23, 2019 Category: Cardiology Tags: Cardiology News Alert Source Type: news
Updated: Torrent Pharmaceuticals Limited Expands Voluntary Nationwide Recall of Losartan Potassium Tablets, USP and Losartan Potassium / Hydrochlorothiazide Tablets, USP
Torrent Pharmaceuticals Limited is expanding its recall for Losartan Potassium Tablets USP and Losartan Potassium/hydrochlorothiazide tablets, USP, to the consumer level due to the detection of trace amounts of an unexpected impurity. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - September 20, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news
Ghana: Time of Administration Ofanti-Hypertensives - Effect of Chronotherapy
[Ghanaian Times] What is the best time to take my B.P. medications (antihypertensives)? It depends on the medication, and the number of medications. If is a water pill (diuretic such as Bendrofluazide) it is better to take it in the morning because you will be passing a lot of urine. There are some that can make you a bit dizzy, especially for first-timers (e.g. Doxazocin, Lisinopril, Losartan) and are therefore better taken at night. There is another aspect, which needs to be considered. It is referred to as Chronotherapy (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - August 28, 2019 Category: African Health Source Type: news
Torrent Pharmaceuticals Limited Expands Voluntary Nationwide Recall of Losartan Potassium Tablets, USP
Torrent Pharmaceuticals Limited is expanding its voluntary recall from 2 lots of Losartan potassium tablets USP to a total of 10 lots, to the consumer level due to the detection of trace amounts of an unexpected impurity found in an active pharmaceutical ingredient (API) manufactured by Hetero Labs (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - July 30, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news
Legacy Pharmaceutical Packaging, LLC Issues Voluntary Nationwide Recall of Losartan Potassium Tablets, USP, 25mg, 50mg, and 100mg Due to the Detection of Trace Amounts of N-Nitroso N-Methyl 4-Amino Butyric Acid (NMBA) Impurity Found in the Active Pharmaceutical Ingredient (API)
Recalling 40 repackaged lots of Losartan Tablets USP 25mg, 50mg, and 100mg to the consumer level. This recall was prompted due to Camber Pharmaceuticals, Inc. issuing a Voluntary Nationwide Recall of Losartan Tablets, USP, due to the detection of trace amounts of N-Nitroso N-Methyl 4-amino butyric (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - July 23, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news
Legacy Pharmaceutical Packaging, LLC Issues Voluntary Nationwide Recall of Losartan Potassium Tablets, USP, 50mg Due to the Detection of Trace Amounts of N-Nitroso N-Methyl 4-amino butyric acid (NMBA) Impurity found in the Active Pharmaceutical Ingredient (API)
Legacy Pharmaceutical Packaging, LLC is recalling 3 repackaged lots of Losartan Tablets USP 50mg to the consumer level. This recall was prompted due to Torrent Pharmaceuticals LTD issuing a Voluntary Nationwide Recall of Losartan Tablets, USP, due to the detection of trace amounts of N-Nitroso N-Met (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - July 23, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news
Teva Pharmaceuticals USA, Inc. Issues Voluntary Nationwide Recall of Losartan Potassium 25 mg and 100 mg Tablets USP, Sold Exclusively to Golden State Medical Supply
Teva Pharmaceuticals USA, Inc. has initiated a voluntary recall in the United States, to the patient level, of 35 lots of bulk Losartan Potassium USP Tablets (6 lots of 25 mg strength and 29 lots of 100 mg strength). (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - July 23, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news
Legacy Pharmaceutical Packaging, LLC Expands Voluntary Nationwide Recall of Losartan Potassium Tablets, USP, 50mg Due to the Detection of Trace Amounts of N-Nitroso N-Methyl 4-amino butyric acid (NMBA) Impurity Found in the Active Pharmaceutical Ingredient (API)
Legacy Pharmaceutical Packaging, LLC is expanding its consumer-level recall of 3 repackaged lots Losartan Tablets USP 50mg to include one additional lot. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - July 23, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news
Updated: Torrent Pharmaceuticals Limited Expands Voluntary Nationwide Recall of Losartan Potassium Tablets, USP and Losartan Potassium/Hydrochlorothiazide Tablets, USP
Torrent Pharmaceuticals Limited is expanding its recall for Losartan Potassium Tablets USP and Losartan Potassium/hydrochlorothiazide tablets, USP, to the consumer level due to the detection of trace amounts of an unexpected impurity (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - July 23, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news
