Differential effects of cholecalciferol and calcitriol on muscle proteolysis and oxidative stress in angiotensin II ‐induced C2C12 myotube atrophy
Cholecalciferol exhibited beneficial roles, whereas calcitriol possessed the negative impact on skeletal muscle proteostasis in angiotensin II-induced muscle atrophy. AbstractRenin –angiotensin system activation contributes to skeletal muscle atrophy in aging individuals with chronic diseases. We aimed to explore the effects of cholecalciferol (VD3) and calcitriol (1,25VD3) on signaling of muscle proteolysis and oxidative stress in myotubes challenged with angiotensin II (AII). The mouse C2C12 myotubes were assigned to vehicle, AII, AII + VD3, AII + 1,25VD3, and AII + losartan groups. The expression levels...
Source: Physiological Reports - April 17, 2024 Category: Physiology Authors: Muthita Hirunsai,
Ratchakrit Srikuea Tags: ORIGINAL ARTICLE Source Type: research
Shen Shuai II recipe improves renal hypoxia to attenuate renal injury in 5/6 renal ablation/infarction rats and effect evaluation using blood oxygenation level-dependent functional magnetic resonance imaging
Conclusion: The degree of renal oxygenation reduction is correlated with the severity of renal injury in CKD. SSR can improve renal hypoxia to attenuate renal injury in 5/6 (A/I) rats of CKD.PMID:38622926 | DOI:10.1080/0886022X.2024.2338565 (Source: Renal Failure)
Source: Renal Failure - April 16, 2024 Category: Urology & Nephrology Authors: Yizeng Xu Fang Lu Meng Wang Lingchen Wang Chaoyang Ye Shuohui Yang Chen Wang Source Type: research
Development of Losartan Orally Disintegrating Tablets by Direct Compression: a Cost-Effective Approach to Improve Paediatric Patient's Compliance
In conclusion, the ODTs were successfully developed and characterised, suggesting a potential means to accomplish a final prototype that enables an improvement in childhood arterial hypertension treatment.PMID:38589718 | DOI:10.1208/s12249-024-02796-9 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - April 8, 2024 Category: Drugs & Pharmacology Authors: Candela Juan Loreana Gallo Noelia Gonzalez Vidal Source Type: research
Development of Losartan Orally Disintegrating Tablets by Direct Compression: a Cost-Effective Approach to Improve Paediatric Patient's Compliance
In conclusion, the ODTs were successfully developed and characterised, suggesting a potential means to accomplish a final prototype that enables an improvement in childhood arterial hypertension treatment.PMID:38589718 | DOI:10.1208/s12249-024-02796-9 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - April 8, 2024 Category: Drugs & Pharmacology Authors: Candela Juan Loreana Gallo Noelia Gonzalez Vidal Source Type: research
Factors Associated with the Development of Chronic Kidney Disease in Patients with Arterial Hypertension
CONCLUSION: Male sex, age over 60 years, and anemia are risk factors for chronic kidney disease. Nephroprotection, controlled diabetes mellitus, and patient follow-up are factors that prevent its development.PMID:38566818 | PMC:PMC10986410 | DOI:10.2147/IJNRD.S448986 (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - April 3, 2024 Category: Urology & Nephrology Authors: Evelyn Del Socorro Goicochea-Rios Ana Mar ía Chian-García Irma Luz Yupari-Azabache N éstor Iván Gómez Goicochea Source Type: research
Two-phase mechanism in the treatment of corneal stromal fibrosis with topical losartan
Exp Eye Res. 2024 Apr 1:109884. doi: 10.1016/j.exer.2024.109884. Online ahead of print.ABSTRACTRecent studies in rabbits and case reports in humans have demonstrated the efficacy of topical losartan in the treatment of corneal scarring fibrosis after a wide range of injuries, including chemical burns, infections, surgical complications, and some diseases. It is hypothesized that the effect of losartan on the fibrotic corneal stroma occurs through a two-phase process in which losartan first triggers the elimination of myofibroblasts by directing their apoptosis via inhibition of extracellular signal-regulated kinase (ERK)-m...
Source: Experimental Eye Research - April 3, 2024 Category: Opthalmology Authors: Steven E Wilson Source Type: research
Factors Associated with the Development of Chronic Kidney Disease in Patients with Arterial Hypertension
CONCLUSION: Male sex, age over 60 years, and anemia are risk factors for chronic kidney disease. Nephroprotection, controlled diabetes mellitus, and patient follow-up are factors that prevent its development.PMID:38566818 | PMC:PMC10986410 | DOI:10.2147/IJNRD.S448986 (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - April 3, 2024 Category: Urology & Nephrology Authors: Evelyn Del Socorro Goicochea-Rios Ana Mar ía Chian-García Irma Luz Yupari-Azabache N éstor Iván Gómez Goicochea Source Type: research
Two-phase mechanism in the treatment of corneal stromal fibrosis with topical losartan
Exp Eye Res. 2024 Apr 1:109884. doi: 10.1016/j.exer.2024.109884. Online ahead of print.ABSTRACTRecent studies in rabbits and case reports in humans have demonstrated the efficacy of topical losartan in the treatment of corneal scarring fibrosis after a wide range of injuries, including chemical burns, infections, surgical complications, and some diseases. It is hypothesized that the effect of losartan on the fibrotic corneal stroma occurs through a two-phase process in which losartan first triggers the elimination of myofibroblasts by directing their apoptosis via inhibition of extracellular signal-regulated kinase (ERK)-m...
Source: Experimental Eye Research - April 3, 2024 Category: Opthalmology Authors: Steven E Wilson Source Type: research
Factors Associated with the Development of Chronic Kidney Disease in Patients with Arterial Hypertension
CONCLUSION: Male sex, age over 60 years, and anemia are risk factors for chronic kidney disease. Nephroprotection, controlled diabetes mellitus, and patient follow-up are factors that prevent its development.PMID:38566818 | PMC:PMC10986410 | DOI:10.2147/IJNRD.S448986 (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - April 3, 2024 Category: Urology & Nephrology Authors: Evelyn Del Socorro Goicochea-Rios Ana Mar ía Chian-García Irma Luz Yupari-Azabache N éstor Iván Gómez Goicochea Source Type: research
