Late ‐Stage Peptide Diversification through Cobalt‐Catalyzed C−H Activation: Sequential Multicatalysis for Stapled Peptides
AngewchemLate ‐Stage Peptide Diversification through Cobalt‐Catalyzed C−H Activation: Sequential Multicatalysis for Stapled PeptidesDr. M élanie M. Lorion, Nikolaos Kaplaneris, Dr. Jongwoo Son, Dr. Rositha Kuniyil, Prof. Dr. Lutz Ackermann C −H activation meets metathesis: Bioorthogonal C −H activation of peptides was accomplished by using air‐and moisture‐stable catalysts based on Earth‐abundant cobalt. This reaction set the stage for the combination of C−H functionalization and olefin metathesis to construct complex cyclic peptides. (Source: Organometallic Current)
Source: Organometallic Current - January 10, 2019 Category: Chemistry Tags: C-H Activation Co catalyzed Late Stage Functionalization Pd Catalyzed Peptide Modification Ru catalyzed Source Type: blogs
How Could We Reconcile Health Technologies and Environmental Sustainability?
The growth of the digital health market entails the appearance of newer and newer fitness trackers, wearables, health sensors – leaving the older models to the sock drawer or worse, the dustbin. What happens to health tech’s waste and what options do people have who don’t want their gadgets to end up in the trash towns of developing countries?
More plastic than fish in the oceans soon
“If the present trends continue, by 2050 our oceans will have more plastic than fish”, said Antonio Guterres, Secretary-General of the United Nations to mark World Environment Day in June 2018. Not only the oceans started to be fil...
Source: The Medical Futurist - November 24, 2018 Category: Information Technology Authors: nora Tags: Bioethics Business Healthcare Design Healthcare Policy Policy Makers Researchers digital health digital health tech e-waste electronic environment green health technology Innovation planet recycling sustainability Source Type: blogs
A patient waits. And waits.
I sit before you and others like you, in silence, anxious about what I might be told. You deliver a litany of questions to my countenance as I sit in a chair beside you. Your attention is diverted to the cold and detached computer screen where my responses are entered without you ever noticing the fear in my eyes. There is no acknowledgment to indicate a level of understanding of my plight. How can I place my trust, which is sacred to me, to someone who doesn’t know me? How I wish to share my story because to know my story is to truly know me. But there seems to be no time for that. No time for empathy. No time for u...
Source: Kevin, M.D. - Medical Weblog - September 21, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/michele-luckenbaugh" rel="tag" > Michele Luckenbaugh < /a > Tags: Patient Patients Primary Care Source Type: blogs
LITFL Review 344
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
Welcome to the 344th LITFL Review! Your regular and reliable source for the highest highlights, sneakiest sneak peeks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the blogosphere’s best and brightest and deliver a bite-sized chunk of FOAM.
The Most Fair Dinkum Ripper Beauts of the Week
Catch up with the Curbsiders and hear Renee Dversdal talk about her passion for IMPOCUS...
Source: Life in the Fast Lane - August 20, 2018 Category: Emergency Medicine Authors: Marjorie Lazoff, MD Tags: LITFL review LITFL R/V Source Type: blogs
First Blood Flow Diverting Stent for Large and Giant Brain Aneurysms Approved in U.S.
Stryker won FDA pre-market approval for its Surpass Streamline Flow Diverter, a device indicated for treatment of large and even giant unruptured intracranial aneurysms. This is only the second flow diverting stent to be approved in the U.S., the first being from Medtronic.
“Surpass Streamline is the first flow diverter indicated for large and giant posterior communicating artery aneurysms. These unruptured aneurysms are more challenging due to their location and surrounding anatomy. Having Surpass approved for this and other locations is an important advantage for physicians and patients,” in a published ...
Source: Medgadget - July 16, 2018 Category: Medical Devices Authors: Editors Tags: Neurology Neurosurgery Radiology Source Type: blogs
Stryker ’s Blood Flow Diverting Stent for Large and Giant Brain Aneurysms Approved in U.S.
Stryker won FDA pre-market approval for its Surpass Streamline Flow Diverter, a device indicated for treatment of large and even giant unruptured intracranial aneurysms. This is only the second flow diverting stent to be approved in the U.S., the first being from Medtronic.
“Surpass Streamline is the first flow diverter indicated for large and giant posterior communicating artery aneurysms. These unruptured aneurysms are more challenging due to their location and surrounding anatomy. Having Surpass approved for this and other locations is an important advantage for physicians and patients,” in a published ...
Source: Medgadget - July 16, 2018 Category: Medical Devices Authors: Editors Tags: Neurology Neurosurgery Radiology Source Type: blogs
Catalytic Dibenzocyclooctene Synthesis via Cobalt(III) –Carbene Radical and ortho‐Quinodimethane Intermediates
AngewchemCatalytic Dibenzocyclooctene Synthesis via Cobalt(III) –Carbene Radical and ortho‐Quinodimethane Intermediates: The metalloradical activation of ortho ‐benzallylaryl N‐tosyl hydrazones with [Co(TPP)] (TPP=tetraphenylporphyrin) as the catalyst enabled the controlled exploitation of the single‐electron reactivity of... (Source: Organometallic Current)
Source: Organometallic Current - December 8, 2017 Category: Chemistry Tags: Co catalyzed Radical Reactions Source Type: blogs
Thioamide ‐Directed Cobalt(III)‐Catalyzed Selective Amidation of C(sp3)−H Bonds
AngewchemThioamide ‐Directed Cobalt(III)‐Catalyzed Selective Amidation of C(sp3)−H Bonds: A mild, oxidant ‐free, and selective Cp*CoIII‐catalyzed amidation of thioamides with robust dioxazolone amidating agents via C(sp3)−H bond activation to generate the desired amidated products is reported.... (Source: Organometallic Current)
Source: Organometallic Current - December 1, 2017 Category: Chemistry Tags: Amidation Co catalyzed Sp3 Functionalization Source Type: blogs
Electrochemical Cobalt-Catalyzed C –H Oxygenation at Room Temperature
JacsElectrochemical Cobalt-Catalyzed C –H Oxygenation at Room Temperature: Electrochemical cobalt-catalyzed C –H functionalizations were achieved in terms of C–H oxygenation under mild conditions at 23 °C. The robust electrochemical C–H functionalization was characterized by ample substrate scope, whereas mechanistic studies provided support for a facile C–H cleavage. (Source: Organometallic Current)
Source: Organometallic Current - November 29, 2017 Category: Chemistry Tags: C-H Oxygenation Co catalyzed Electrochemical Source Type: blogs
Cobalt ‐Catalyzed Suzuki Biaryl Coupling of Aryl Halides
AngewchemCobalt ‐Catalyzed Suzuki Biaryl Coupling of Aryl Halides: Readily accessed cobalt pre ‐catalysts with N‐heterocyclic carbene ligands catalyze the Suzuki cross‐coupling of aryl chlorides and bromides with alkyllithium‐activated arylboronic pinacolate esters. Preliminary... (Source: Organometallic Current)
Source: Organometallic Current - November 29, 2017 Category: Chemistry Tags: Arylation C-C Bond Forming Co catalyzed Source Type: blogs
Catalytic Enantioselective Hetero-dimerization of Acrylates and 1,3-Dienes
JacsCatalytic Enantioselective Hetero-dimerization of Acrylates and 1,3-Dienes: 1,3-Dienes are ubiquitous and easily synthesized starting materials for organic synthesis, and alkyl acrylates are among the most abundant and cheapest feedstock carbon sources. A practical, highly enantioselective union of these two readily available precursors giving valuable, enantio-pure skipped 1,4-diene esters (with two configurationally defined double bonds) is reported. The process uses commercially available cobalt salts and chiral ligands. (Source: Organometallic Current)
Source: Organometallic Current - November 28, 2017 Category: Chemistry Tags: Co catalyzed Dimerization Source Type: blogs
Electrochemical Cobalt-Catalyzed C –H Oxygenation at Room Temperature
JacsElectrochemical Cobalt-Catalyzed C –H Oxygenation at Room Temperature: Electrochemical cobalt-catalyzed C –H functionalizations were achieved in terms of C–H oxygenation under mild conditions at 23 °C. The robust electrochemical C–H functionalization was characterized by ample substrate scope, whereas mechanistic studies provided support for a facile C–H cleavage. The electrochemical cobalt -catalyzed C–H oxygenation proved viable on arenes and alkenes with excellent levels of positional and diastereo-selectivity, avoiding the use of stoichiometric silver(I) oxidants under ambient conditions. (Source: Organometallic Current)
Source: Organometallic Current - November 28, 2017 Category: Chemistry Tags: C-H Oxygenation Co catalyzed Electrochemical Room Temp Rxn Source Type: blogs
DynamX, a Novel Stent That Turns from Rigid to Flexible While Inside Vessel
With every heart beat, our blood vessels expand and contract, something known as pulsatile motion. When commonly used metal stents are placed within vessels, they prevent those vessels from exhibiting pulsatile motion. This may be a cause of or a compounding factor for restenosis and may even lead to a cardiovascular disease to develop faster.
Elixir Medical, a Milpitas, California firm, has developed a drug eluting stent that structurally behaves the same as a traditional metal stent, but after a few months becomes more flexible, allowing pulsatile motion to take over the vessel. The so-called bioadaptive DynamX cobalt ...
Source: Medgadget - November 8, 2017 Category: Medical Devices Authors: Editors Tags: Cardiology Radiology Vascular Surgery Source Type: blogs
