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Relative impact of THPO mutation causing hereditary thrombocythemia
Essential thrombocythemia (ET) is a chronic myeloproliferative neoplasm that is characterized by sustained proliferation of megakaryocytes and thrombocytosis. An elevated platelet count results in thrombotic or hemorrhagic episodes. ET occasionally causes leukemic transformation or myelofibrosis. Somatic mutations of JAK2, MPL, and CALR are frequently observed in cases of ET. Hereditary thrombocythemia (HT) is an autosomal-dominant disorder and its clinical features resemble those of sporadic ET. (Source: Experimental Hematology)
Source: Experimental Hematology - March 26, 2024 Category: Hematology Authors: Hiroyuki Kimura, Masahiro Onozawa, Toshihiro Matsukawa, Hideki Goto, Takeshi Kondo, Takanori Teshima Tags: Brief Communication Source Type: research

The impact of statin use on disease-related symptoms in patients with chronic myeloproliferative neoplasms
(Source: Annals of Hematology)
Source: Annals of Hematology - March 13, 2024 Category: Hematology Source Type: research

Recombinant interferon alfa in BCR/ABL-negative chronic myeloproliferative neoplasms
This article reviews the clinical research and recent advances that led to the first regulatory approval of IFN-α in a BCR/ABL-negative MPN and its future promise as a disease-modifying therapeutic agent.PMID:38446475 (Source: Clinical Advances in Hematology and Oncology)
Source: Clinical Advances in Hematology and Oncology - March 6, 2024 Category: Cancer & Oncology Authors: Sandy El Bitar Murat O Arcasoy Source Type: research