A protocol update for the Selenium Treatment and Chagasic Cardiomyopathy (STCC) trial
AbstractSeveral studies evaluating clinical forms of chronic Chagas disease show that about one-third of patients present cardiac involvement. Heart failure, sudden death and cardioembolic stroke are the main mechanisms of death in Chagas heart disease. The impact of specific etiologic treatment on the prognosis of patients with chronic Chagas heart disease is very limited regardless of the presence or absence of heart failure. Patients with symptomatic Chagas heart disease present serum selenium (Se) levels lower than patients without Chagas heart disease. Moreover, Se supplementation in animal models showed promising res...
Source: Trials - September 19, 2018 Category: Research Source Type: clinical trials
Oral Fexinidazole Dosing Regimens for the Treatment of Adults With Chronic Indeterminate Chagas Disease
Condition: Chagas' Disease (Chronic) Nos Interventions: Drug: Fexinidazole; Drug: Placebo Oral Tablet Sponsor: Drugs for Neglected Diseases Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 16, 2018 Category: Research Source Type: clinical trials
