Translating from Chemistry to Clinic with Deep Learning
NLM Informatics and Data Science Lecture Series
Many medicines become toxic only after bioactivation by metabolizing enzymes. Often, metabolic enzymes transformed them into chemically reactive species, which subsequently conjugate to proteins and cause adverse events. For example, carbamazepine is epoxidized by P450 enzymes in the liver, but then conjugates to proteins, causing Stevens Johnson Syndrome in some patients. The most difficult to predict drug reactions, idiosyncratic adverse drug reactions, often depend on bioactivation. Our group has been using deep learning to model the metabolism of diverse chemicals, and th...
Source: Videocast - All Events - February 12, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
