DETERMINE Trial Treatment Arm 2: Atezolizumab in Adult, Teenage/Young Adults and Paediatric Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition
Conditions:   Malignancy;   Malignant Neoplasm;   Lymphoproliferative Disorders;   Neoplasms by Histologic Type;   Neoplasms by Site;   Cancer;   Colorectal Neoplasms;   Endometrial Neoplasms;   Melanoma Intervention:   Drug: Atezolizumab Sponsors:   Cancer Research UK;   University of Manchester;   University of Birmingham;   Royal Marsden NHS Foundation Trust;   Hoffmann-La Roche Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2023 Category: Research Source Type: clinical trials

DETERMINE Trial Treatment Arm 1: Alectinib in Adult, Teenage/Young Adults (TYA) and Paediatric Patients With ALK Positive Cancers
Conditions:   Solid Tumor;   Haematological Malignancy;   Malignant Neoplasm;   Lymphoproliferative Disorders;   Neoplasms by Histologic Type;   Neoplasms by Site;   Cancer;   Anaplastic Large Cell Lymphoma;   Lymphoma;   Renal Cell Carcinoma;   Neuroblastoma Intervention:   Drug: Alectinib Sponsors:   Cancer Research UK;   University of Manchester;   University of Birmingham;   Royal Marsden NHS Foundation Trust;   Hoffmann-La Roche Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2023 Category: Research Source Type: clinical trials

DETERMINE Trial Treatment Arm 3: Entrectinib in Adult, Teenage/Young Adults and Paediatric Patients With ROS1 Gene Fusion-positive Cancers.
Conditions:   Solid Tumor;   Haematological Malignancy;   Malignancy;   Malignant Neoplasm;   Lymphoproliferative Disorders;   Neoplasms by Histologic Type;   Neoplasms by Site;   Cancer;   Brain Neoplasms;   Melanoma;   Glioma Intervention:   Drug: Entrectinib Sponsors:   Cancer Research UK;   University of Manchester;   University of Birmingham;   Royal Marsden NHS Foundation Trust;   Hoffmann-La Roche Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2023 Category: Research Source Type: clinical trials

DETERMINE Trial Treatment Arm 2: Atezolizumab in Adult, Teenage/Young Adults and Paediatric Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition
Conditions:   Malignancy;   Malignant Neoplasm;   Lymphoproliferative Disorders;   Neoplasms by Histologic Type;   Neoplasms by Site;   Cancer;   Colorectal Neoplasms;   Endometrial Neoplasms;   Melanoma Intervention:   Drug: Atezolizumab Sponsors:   Cancer Research UK;   University of Manchester;   University of Birmingham;   Royal Marsden NHS Foundation Trust;   Hoffmann-La Roche Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2023 Category: Research Source Type: clinical trials

DETERMINE Trial Treatment Arm 1: Alectinib in Adult, Teenage/Young Adults (TYA) and Paediatric Patients With ALK Positive Cancers
Conditions:   Solid Tumor;   Haematological Malignancy;   Malignant Neoplasm;   Lymphoproliferative Disorders;   Neoplasms by Histologic Type;   Neoplasms by Site;   Cancer;   Anaplastic Large Cell Lymphoma;   Lymphoma;   Renal Cell Carcinoma;   Neuroblastoma Intervention:   Drug: Alectinib Sponsors:   Cancer Research UK;   University of Manchester;   University of Birmingham;   Royal Marsden NHS Foundation Trust;   Hoffmann-La Roche Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2023 Category: Research Source Type: clinical trials

DETERMINE Trial Treatment Arm 3: Entrectinib in Adult, Teenage/Young Adults and Paediatric Patients With ROS1 Gene Fusion-positive Cancers.
Conditions:   Solid Tumor;   Haematological Malignancy;   Malignancy;   Malignant Neoplasm;   Lymphoproliferative Disorders;   Neoplasms by Histologic Type;   Neoplasms by Site;   Cancer;   Brain Neoplasms;   Melanoma;   Glioma Intervention:   Drug: Entrectinib Sponsors:   Cancer Research UK;   University of Manchester;   University of Birmingham;   Royal Marsden NHS Foundation Trust;   Hoffmann-La Roche Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2023 Category: Research Source Type: clinical trials

DETERMINE Trial Treatment Arm 2: Atezolizumab in Adult, Teenage/Young Adults and Paediatric Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition
Conditions:   Malignancy;   Malignant Neoplasm;   Lymphoproliferative Disorders;   Neoplasms by Histologic Type;   Neoplasms by Site;   Cancer;   Colorectal Neoplasms;   Endometrial Neoplasms;   Melanoma Intervention:   Drug: Atezolizumab Sponsors:   Cancer Research UK;   University of Manchester;   University of Birmingham;   Royal Marsden NHS Foundation Trust;   Hoffmann-La Roche Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2023 Category: Research Source Type: clinical trials

DETERMINE Trial Treatment Arm 1: Alectinib in Adult, Teenage/Young Adults (TYA) and Paediatric Patients With ALK Positive Cancers
Conditions:   Solid Tumor;   Haematological Malignancy;   Malignant Neoplasm;   Lymphoproliferative Disorders;   Neoplasms by Histologic Type;   Neoplasms by Site;   Cancer;   Anaplastic Large Cell Lymphoma;   Lymphoma;   Renal Cell Carcinoma;   Neuroblastoma Intervention:   Drug: Alectinib Sponsors:   Cancer Research UK;   University of Manchester;   University of Birmingham;   Royal Marsden NHS Foundation Trust;   Hoffmann-La Roche Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2023 Category: Research Source Type: clinical trials

DETERMINE Trial Treatment Arm 3: Entrectinib in Adult, Teenage/Young Adults and Paediatric Patients With ROS1 Gene Fusion-positive Cancers.
Conditions:   Solid Tumor;   Haematological Malignancy;   Malignancy;   Malignant Neoplasm;   Lymphoproliferative Disorders;   Neoplasms by Histologic Type;   Neoplasms by Site;   Cancer;   Brain Neoplasms;   Melanoma;   Glioma Intervention:   Drug: Entrectinib Sponsors:   Cancer Research UK;   University of Manchester;   University of Birmingham;   Royal Marsden NHS Foundation Trust;   Hoffmann-La Roche Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2023 Category: Research Source Type: clinical trials

DETERMINE Trial Treatment Arm 2: Atezolizumab in Adult, Teenage/Young Adults and Paediatric Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition
Conditions:   Malignancy;   Malignant Neoplasm;   Lymphoproliferative Disorders;   Neoplasms by Histologic Type;   Neoplasms by Site;   Cancer;   Colorectal Neoplasms;   Endometrial Neoplasms;   Melanoma Intervention:   Drug: Atezolizumab Sponsors:   Cancer Research UK;   University of Manchester;   University of Birmingham;   Royal Marsden NHS Foundation Trust;   Hoffmann-La Roche Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2023 Category: Research Source Type: clinical trials

DETERMINE Trial Treatment Arm 1: Alectinib in Adult, Teenage/Young Adults (TYA) and Paediatric Patients With ALK Positive Cancers
Conditions:   Solid Tumor;   Haematological Malignancy;   Malignant Neoplasm;   Lymphoproliferative Disorders;   Neoplasms by Histologic Type;   Neoplasms by Site;   Cancer;   Anaplastic Large Cell Lymphoma;   Lymphoma;   Renal Cell Carcinoma;   Neuroblastoma Intervention:   Drug: Alectinib Sponsors:   Cancer Research UK;   University of Manchester;   University of Birmingham;   Royal Marsden NHS Foundation Trust;   Hoffmann-La Roche Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2023 Category: Research Source Type: clinical trials

DETERMINE Trial Treatment Arm 3: Entrectinib in Adult, Teenage/Young Adults and Paediatric Patients With ROS1 Gene Fusion-positive Cancers.
Conditions:   Solid Tumor;   Haematological Malignancy;   Malignancy;   Malignant Neoplasm;   Lymphoproliferative Disorders;   Neoplasms by Histologic Type;   Neoplasms by Site;   Cancer;   Brain Neoplasms;   Melanoma;   Glioma Intervention:   Drug: Entrectinib Sponsors:   Cancer Research UK;   University of Manchester;   University of Birmingham;   Royal Marsden NHS Foundation Trust;   Hoffmann-La Roche Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2023 Category: Research Source Type: clinical trials

DETERMINE Trial Treatment Arm 2: Atezolizumab in Adult, Teenage/Young Adults and Paediatric Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition
Conditions:   Malignancy;   Malignant Neoplasm;   Lymphoproliferative Disorders;   Neoplasms by Histologic Type;   Neoplasms by Site;   Cancer;   Colorectal Neoplasms;   Endometrial Neoplasms;   Melanoma Intervention:   Drug: Atezolizumab Sponsors:   Cancer Research UK;   University of Manchester;   University of Birmingham;   Royal Marsden NHS Foundation Trust;   Hoffmann-La Roche Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2023 Category: Research Source Type: clinical trials

DETERMINE Trial Treatment Arm 1: Alectinib in Adult, Teenage/Young Adults (TYA) and Paediatric Patients With ALK Positive Cancers
Conditions:   Solid Tumor;   Haematological Malignancy;   Malignant Neoplasm;   Lymphoproliferative Disorders;   Neoplasms by Histologic Type;   Neoplasms by Site;   Cancer;   Anaplastic Large Cell Lymphoma;   Lymphoma;   Renal Cell Carcinoma;   Neuroblastoma Intervention:   Drug: Alectinib Sponsors:   Cancer Research UK;   University of Manchester;   University of Birmingham;   Royal Marsden NHS Foundation Trust;   Hoffmann-La Roche Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2023 Category: Research Source Type: clinical trials

DETERMINE Trial Treatment Arm 3: Entrectinib in Adult, Teenage/Young Adults and Paediatric Patients With ROS1 Gene Fusion-positive Cancers.
Conditions:   Solid Tumor;   Haematological Malignancy;   Malignancy;   Malignant Neoplasm;   Lymphoproliferative Disorders;   Neoplasms by Histologic Type;   Neoplasms by Site;   Cancer;   Brain Neoplasms;   Melanoma;   Glioma Intervention:   Drug: Entrectinib Sponsors:   Cancer Research UK;   University of Manchester;   University of Birmingham;   Royal Marsden NHS Foundation Trust;   Hoffmann-La Roche Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2023 Category: Research Source Type: clinical trials