144 Investigating the molecular mechanisms of mutant C9orf72 human iPSC- derived astrocyte-mediated motor neuron deficits
Amyotrophic Lateral Sclerosis (ALS) is a progressive, incurable and invariably fatal neurodegenerative condition characterised by loss of motor neurons. Over the last two decades, there are multiple lines of evidence from pathology, genetics and experimental systems that implicate a central role for non- neuronal cells, astrocytes in particular, with ALS pathogenesis. This is not surprising given the intimate structural and functional association of astrocytes with, inter alia, the synapse and vasculature. Yet, the nature of this astrocyte-neuronal crosstalk remains understudied. Harnessing the power of genetic dis- coveri...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Stavrou, M., Selvaraj, B., Bolado, A., James, L., Neil, C., Margaret, F., Hardingham, G., Chandran, S. Tags: Live Poster, 13 May Poster Session 2 Source Type: research
033 GLP-1RAs reduce stroke incidence in patients with type 2 diabetes mellitus: a meta-analysis
Conclusions
This data supports the value of GLP-1RAs in reducing stroke incidence in patients with T2DM. There is potential value in prospective, randomised controlled trials adequately powered to establish the value of GLP-1RAs in stroke prevention in T2DM patients.
mark.maskery@doctors.org.uk|ABN Bursary (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Maskery, M., Wall, J., Holscher, C., Jones, S., Price, C., Strain, D., Watkins, C., Werring, D., Emsley, H. Tags: Live Poster, 6 May SIG4: Movement Disorders Source Type: research
037 New insight into dysautonomia in GFAP astrocytopathy
We describe the first in-depth autonomic testing in GFAP astrocytopathy which shows sympathetic cardio- vascular failure and evidence of sudomotor post-ganglionic dysfunction.
yeeyen.goh@nhs.net|ABN Bursary (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Goh, Y. Y., Koay, S., Goodall, J., Oommens, G., Ingle, G., Parris, V., Iodice, V., Swanton, J., McNamara, P. Tags: Live Poster, 13 May Poster Session 1 Source Type: research
038 Investigatory imaging in autoimmune-paraneoplastic encephalitis
Conclusion
Body CT was the commonest imaging investigation performed at presentation and only a little over half had further investigations if initial CT was negative. No patient that responded to initial treatment had further investigations to look for an underlying malignancy. There is an urgent need for follow up studies that will inform future imaging criteria for AIE-PNE.
arshia
seddigh@nhs.net|ABN Bursary
44 (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Seddigh, A., Arun, T. Tags: Live Poster, 13 May Poster Session 1 Source Type: research
042 Opportunities and challenges of remote neurological outpatient consultations
Croydon University Hospital
Remote consultations were rapidly introduced in the spring of 2020 in the neurology outpatient setting across the UK and worldwide due to the Covid-19 pandemic. Consulting remotely provides new chal- lenges to previously familiar practices. Here we present four different but commonly seen cases in a south London outpatient neurology service. With each case we address a key domain: history taking, examina- tion, the digital divide and changing the consulting environment. History taking is largely unchanged and indeed may improve the patient experience when performed in a familiar environment. The...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Hogan, J., MacDonald, B., Mastrolilli, F., Nitkunan, A. Tags: Live Poster, 13 May Poster Session 2 Source Type: research
046 Preparing new registrars for practice in the age of Zoom
Conclusion
The Covid-19 pandemic brought tumultuous shifts in practice that were uncharted waters for the entire neurological community. As we all tried to stay afloat, we also provided a necessary life-raft to trainees who were negotiating the challenge of the transition to being a neurology registrar.
rnrees@gmail.com|ABN Bursary
48 (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Rees, R., Russell, A. R., Patel, F., Lawrence, J., Jones, M., Warner, T. Tags: Live Poster, 13 May Poster Session 2 Source Type: research
051 Peripheral nerve blocks in combination with onabotulinum toxin A treatment to improve migraine outcomes
There is no evidence base on the efficacy of onabotulinum toxin A treatment and peripheral nerve blocks (PNBs) when used in combination to treat chronic migraine. This retrospective single centre evaluation looked at outcomes from 198 headache service users who had been managed with onabotulinum toxin A treatment alone (n=97), PNBs alone (n=43) or both treatments in combination (n=58). 85% of patients who had PNBs alone considered them effective in reducing their headache burden on follow-up, compared to 71% of patients who had onabotulinum toxin A treatment only. In patients who received both headache treatments, due to i...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Germain, L., Hilton, J., Amores, F., Fernandes, L., Randall, M., Idrovo, L. Tags: Live Poster, 29 April SIG3: Headache Source Type: research
055 Insights into a secondary care headache service
Conclusion
As new treatments such as monoclonal antibodies become available for migraine, ongoing discussion will be vital to ensure headache services can adapt and deliver these therapies effectively.
j.scott3@uni.bsms.ac.uk|ABN Bursary (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Scott, J., Bateman, K., Cottam, R., Muddle, L., Young, E., Ridha, B., Ganesalingam, J. Tags: Live Poster, 29 April SIG3: Headache Source Type: research
060 Calcitonin gene-related peptide monoclonal antibody treats headache in patients with active idiopathic intracranial hypertension
Conclusions
Those with prior IIH who have their headaches successfully treated with CGRP therapy, should remain under close ocular surveillance (particularly when weight gain is evident) as papilloedema can re-occur in the absence of headache. These cases may suggest that CGRP could be a mechanistic driver for headache in patients with active IIH.
a.yiangou@bham.ac.uk|NIHR Bursary
55 (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Yiangou, A., Mitchell, J., Vijay, V., Grech, O., Bilton, E., Lavery, G., Fisher, C., Edwards, J., Mollan, S., Sinclair, A. Tags: Live Poster, 29 April SIG3: Headache Source Type: research
032 Improving access to inpatient ambulatory cardiac monitoring for acute stroke patients during the Covid-19 pandemic
Discussion
There was a significant shift in clinical practice and diagnostic access to inpatient ACM during the pandemic, resulting in a greater proportion of tests, increased identification of AF and early anticoagulation, leading to improved patient care and potentially preventing further ischaemic events.
harriet
jeffery@nhs.net|ABN Bursary
41 (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Jeffery, H., Sanz, E. R., Turner, D. Tags: Live Poster, 6 May SIG4: Movement Disorders Source Type: research
030 Emerging parkinsonism in the PREDICT-PD cohort after 5-year follow-up
Conclusions
This study identifies early motor features and their evolution during PD pre-diagnostic phase. Remotely administered tools may be capable of detecting subtle motor dysfunction at early stages of PD.
c.simonet@qmul.ac.uk|NIHR Bursary
40 (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Simonet, C., Bestwick, J., Schrag, A., Lees, A., Noyce, A. Tags: Live Poster, 6 May SIG4: Movement Disorders Source Type: research
029 Postural instability in DYT-TOR1A dystonia dynamically dependent on sensory feedback
Dystonia is clinically defined as a disorder of posture yet there has been little systematic exploration of postural control in the laboratory. Patients with DYT-TOR1A dystonia held the handle of a planar robotic arm to make point-to-point reaching movements with their symptomatic right arm. Reaches were made from a central start box to eccentric targets (15°, 135°, 225° or 315°). Position was then held within the target box for 10s. Estimation of arm position was dependent on proprioceptive and visual feedback (experimentally manipulated with balanced pseudo-randomization: cursor visible or not visible). D...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Sadnicka, A., Dennis, E., Bhatia, K., Rothwell, J., Chen, X., Galea, J. Tags: Live Poster, 6 May SIG4: Movement Disorders Source Type: research
When the rhythm moves you
We present a rare case of GAD-Ab mediated MRS. MRS are well described, with 9% mediated by GAD-Ab. This mechanistically accounts for the limbic MRS semiology. We highlight the importance of GAD-Ab screening for refractory new onset TLE in an adult, with high serum GAD-Ab titre (≥2000 U/mL) and evidence of intrathecal synthesis. Unlike other immune-mediated epilepsies, GAD-Ab-mediated epilepsy responds poorly to AEDs and may require immunosuppression with rituximab or cyclophosphamide.
References
1. Kaplan, 2003; Falip et al., 2018, 2019; Tseng et al., 2018; Dade et al., 2020; Jesus-Ribeiro et al., 2020
anishadoshi@doct...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Doshi, A., Midgley, L., Kyaw, K. M., Tsarouchas, N., Redmond, I., Harikhrishnan, S., Memon, S. Tags: Case Presentation: 01 Source Type: research
002 A review of the performance of referring centres in diagnosing sCJD on MRI
Conclusions
MRI reporting of sCJD by referring centres has improved, but further improvement seems possible. We re-emphasize the importance of analysing scans thoroughly for characteristic MRI patterns of sCJD to enable earlier identification of these patients.
danielle
sequeira@nhs.net|ABN Bursary
26 (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Sequeira, D., Jesuthasan, A., Hyare, H., Odd, H., Rudge, P., Mok, T. H., Nihat, A., Collinge, J., Mead, S. Tags: Live Poster, 6 May SIG5: Cognitive Disorders Source Type: research
003 Neuroanatomical signatures of genetic risk for Alzheimers disease in healthy adults
Conclusion
Genetic liability to AD is associated with preclinical neurodegeneration in grey and white matter components of the limbic system. Integrity of this network could serve as a marker of preclinical AD and an outcome measure in prevention trials.
cameron.watson@qmul.ac.uk|ABN Bursary (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Watson, C., Waters, S., Jacobs, B., Foote, I., Dey, S., Noyce, A., Marshall, C., equal contribution Tags: Live Poster, 6 May SIG5: Cognitive Disorders Source Type: research
