Building Neuroscience Research Infrastructure for Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) in Africa (UG3/UH3 Clinical Trial Not Allowed)
Funding Opportunity RFA-AG-24-027 from the NIH Guide for Grants and Contracts. This notice of funding opportunity (NOFO) promotes collaborative research programs to support the development/enhancement of infrastructure (e.g., tools, surveys, biospecimens, data) for Alzheimer's disease (AD) and AD-related dementias (AD/ADRD) neuroscience research in low- and middle-income countries (LMICs) in Africa. Specifically, the National Institute on Aging (NIA) seeks to support Phase Innovation Awards Cooperative Agreement (UG3/UH3) projects to enable: (1) the formation of transformative collaborations between institutions/scienti...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 25, 2023 Category: Research Source Type: funding
Seamless Early-Stage Clinical Drug Development (Phase 1 to 2a) for Novel therapeutic Agents for the Spectrum of Alzheimer's Disease (AD) and AD-related Dementias (ADRD) (UG3/UH3 Clinical Trial Required)
Funding Opportunity PAR-23-274 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to invite applications that bundle independent protocols for phase 1 clinical trials with phase 1b/phase 2a clinical trials to streamline the early-stage evaluation of promising pharmacological interventions for Alzheimer's disease (AD) and Alzheimer's disease-related Dementias (ADRD). Candidate interventions evaluated through this program, which can include small molecules or biologics for example, must engage non-amyloid/non-tau mechanisms and aim to address cognitive and/or neuropsyc...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 23, 2023 Category: Research Source Type: funding
Chimeric Antigen Receptor (CAR) Approaches to AD/ADRD (R61/R33 Clinical Trial Not Allowed)
Funding Opportunity RFA-AG-24-046 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) aims toprovide a proof-of-principle for a novel strategy for Alzheimer Disease and Alzheimer Related Dementias (AD/ADRD) immunotherapies. Specifically, the goal is to examine if a novel immunotherapeutic approach in cancer immunotherapy with Chimeric Antigen Receptor (CAR) immune cellscould be customized as treatments for AD/ADRD. This NOFO utilizes the R61/R33Exploratory/Developmental Phased Award activity code. The R61 phase provides up to 2 years of support for initial developmental activities. The...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 23, 2023 Category: Research Source Type: funding
Analytical and Clinical Validation of Biomarkers for Alzheimers Disease (AD) and AD-Related Dementias (ADRD) (U01 Clinical Trial Optional)
Funding Opportunity PAR-23-258 from the NIH Guide for Grants and Contracts. The goal of this Notice of Funding Opportunity (NOFO) is to accelerate the establishment ofeffective and reliable biomarkers of Alzheimers disease (AD) and AD-related dementias (ADRD) for usein therapy/medical product discovery and development, clinical trials and/or clinical practice. Specifically, this NOFO willsupport analytical and/or clinical validationof a biomarker, composite biomarker or biomarker signature, withrigor comparable with the expectations described in the Food and Drug Administration (FDA)Biomarker Qualification Program (BQP)...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 16, 2023 Category: Research Source Type: funding
Notice of Special Interest (NOSI): Investigation of Biomolecular Condensates in Aging and Alzheimer's Disease (AD) and AD-related Dementias (ADRD)
Notice NOT-AG-23-037 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 14, 2023 Category: Research Source Type: funding
Neural and Non-Neural Mechanisms Underlying Gait as a Preclinical Marker for Alzheimers Disease and Alzheimers Disease-Related Dementias (R01 Clinical Trial Optional)
Funding Opportunity RFA-AG-24-041 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to invite applications that investigate the neural and/or non-neural mechanisms that underlie the association between gait and cognition in aging and Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD). Elucidating these mechanisms would help inform the potential use of changes gait as an early biomarker of AD/ADRD or inform the design of early interventions for AD/ADRD. To achieve these goals, it will be necessary to facilitate a team science approach by bringing...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 11, 2023 Category: Research Source Type: funding
Behavioral and Social Research on the Role of Immigration on Life Course Health and Aging, including AD/ADRD?(R21 Clinical Trial Not Allowed)
Funding Opportunity RFA-AG-24-029 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites innovative studies that will explore how structural, community, and interpersonal mechanisms operate over the life course among middle aged and older adults to shape health outcomes of Latino/a, Black, Asian, and other first generation immigrant groups in the United States (US) and result in health disparities among these populations. This NOFO also invites innovative studies that will explore data needs and methods when studying the effect of immigration on life course health and Alzheimers d...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 9, 2023 Category: Research Source Type: funding
Behavioral and Social Research on the Role of Immigration on Life Course Health and Aging, including AD/ADRD?(R01 Clinical Trial Not Allowed)
Funding Opportunity RFA-AG-24-028 from the NIH Guide for Grants and Contracts. This notice of funding opportunity (NOFO) invites innovative studies that will explore how structural, community, and interpersonal mechanisms operate over the life course among middle aged and older adults to shape health outcomes of Latino/a, Black, Asian, and other first generation immigrant groups in the United States (US) and result in health disparities among these populations. This NOFO also invites innovative studies that will explore data needs and methods when studying the effect of immigration on life course health and Alzheimers d...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 9, 2023 Category: Research Source Type: funding
Feasibility Trials of the NIH Music-based Interventions Toolkit for Brain Disorders of Aging (R34 Clinical Trial Required)
Funding Opportunity PAR-23-256 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support proof-of-concept feasibility trials guided by the NIH Music-based Interventions (MBI) Toolkit for research on brain disorders of aging. These early phase clinical trials will generate evidence supporting the validity of the NIH MBI Toolkits guiding principles as well as the necessary pilot data to design a subsequent clinical efficacy or effectiveness study (or pragmatic clinical trial) using music-based interventions in the context of brain disorders of aging, including but ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 7, 2023 Category: Research Source Type: funding
Role of Environmental Stress in the Health Inequities of Alzheimer's Disease-Related Dementias (ADRD) (R01 - Clinical Trial Not Allowed)
Funding Opportunity RFA-NS-24-024 from the NIH Guide for Grants and Contracts. The goal of this initiative is to increase our knowledge of how environmental stressors such as heat, crowding, air quality, noise, violence, and adverse childhood experiences in lower resourced communities affect Alzheimers Disease Related Dementias (ADRD). These and other noninheritable factors are collectively known as the exposome and includes environmental stress which is a major factor in racial and ethnic health inequities. ADRD is more prevalent and severe in people who live in lower resourced environments, and there is a need to iden...
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 25, 2023 Category: Research Source Type: funding
Health Equity and the Cost of Novel Treatments for Alzheimers Disease (AD) and AD-Related Dementias (ADRD) (R61/R33 Clinical Trial Not Allowed)
Funding Opportunity RFA-AG-24-050 from the NIH Guide for Grants and Contracts. This NOFO invites R61/R33 applications that address health equity, drug costs, and access to new therapeutics or repurposed drugs for Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD). Successful applications will seek to identify preferences for pharmacological treatment among racial and ethnic minority people living with AD/ADRD, assess whether cost barriers to pharmacological care exist for racial and ethnic minority people living with AD/ADRD, and quantify expenditures and health- related quality of life (HRQoL) amon...
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 19, 2023 Category: Research Source Type: funding
Primary Care-Based Screening Tool and Intervention Development for the Detection and Prevention of Abuse and Neglect in Older and Vulnerable Adults With, or at Risk for, Mild Cognitive Impairment and AD/ADRD (R61/R33 Clinical Trial Required)
Funding Opportunity RFA-AG-24-048 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support research that can lead to the development of evidence-based primary care screening tools and behavioral interventions to prevent abuse in at-risk older and vulnerable adults with mild cognitive impairment (MCI) and Alzheimers disease (AD) and Alzheimer's disease-related dementias (ADRD) and their families. (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 5, 2023 Category: Research Source Type: funding
Notice of Change to Key Dates for RFA-NS-24-009: Optimization of Genome Editing Therapeutics for Alzheimer's Disease-Related Dementias (ADRD) (U01 - Clinical Trials Not Allowed)
Notice NOT-NS-24-007 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 5, 2023 Category: Research Source Type: funding
Notice of Upcoming NIH Early Prediction of Alzheimer's Disease and Alzheimers Disease Related Dementias (AD/ADRD) Open Innovation Challenge
Notice NOT-AG-23-040 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - June 28, 2023 Category: Research Source Type: funding
Optimization of Genome Editing Therapeutics for Alzheimer's Disease-Related Dementias (ADRD) (U01 - Clinical Trials Not Allowed)
Funding Opportunity RFA-NS-24-009 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) supports the optimization of promising genome editing-based therapeutic leads for Alzheimer's Disease-Related Dementias (ADRD), towards IND-enabling studies. Specifically, it supports the characterization and optimization of therapeutic lead(s) that show promise as potential genome editing therapeutics, as evidenced by convincing proof-of-concept studies in appropriate models. At the end of the funding period, successful projects will have optimized a genome editing therapeutic candidate with demonstr...
Source: NIH Funding Opportunities (Notices, PA, RFA) - June 26, 2023 Category: Research Source Type: funding
