HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells
Cell Rep Med. 2023 Oct 17;4(10):101201. doi: 10.1016/j.xcrm.2023.101201. Epub 2023 Oct 6.ABSTRACTNeutralizing antibodies targeting HIV-1 Env have been shown to protect from systemic infection. To explore whether these antibodies can inhibit infection of the first cells, challenge viruses based on simian immunodeficiency virus (SIV) were developed that use HIV-1 Env for entry into target cells during the first replication cycle, but then switch to SIV Env usage. Antibodies binding to Env of HIV-1, but not SIV, block HIV-1 Env-mediated infection events after rectal exposure of non-human primates to the switching challenge vi...
Source: IAVI Rep - October 7, 2023 Category: Infectious Diseases Authors: Viktoria Stab Christiane Stahl-Hennig Armin Ensser Elie Richel Kirsten Fraedrich Ulrike Sauermann Bettina Tippler Florian Klein Dennis R Burton Matthias Tenbusch Klaus Überla Source Type: research
HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells
Cell Rep Med. 2023 Oct 17;4(10):101201. doi: 10.1016/j.xcrm.2023.101201. Epub 2023 Oct 6.ABSTRACTNeutralizing antibodies targeting HIV-1 Env have been shown to protect from systemic infection. To explore whether these antibodies can inhibit infection of the first cells, challenge viruses based on simian immunodeficiency virus (SIV) were developed that use HIV-1 Env for entry into target cells during the first replication cycle, but then switch to SIV Env usage. Antibodies binding to Env of HIV-1, but not SIV, block HIV-1 Env-mediated infection events after rectal exposure of non-human primates to the switching challenge vi...
Source: IAVI Rep - October 7, 2023 Category: Infectious Diseases Authors: Viktoria Stab Christiane Stahl-Hennig Armin Ensser Elie Richel Kirsten Fraedrich Ulrike Sauermann Bettina Tippler Florian Klein Dennis R Burton Matthias Tenbusch Klaus Überla Source Type: research
HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells
Cell Rep Med. 2023 Oct 17;4(10):101201. doi: 10.1016/j.xcrm.2023.101201. Epub 2023 Oct 6.ABSTRACTNeutralizing antibodies targeting HIV-1 Env have been shown to protect from systemic infection. To explore whether these antibodies can inhibit infection of the first cells, challenge viruses based on simian immunodeficiency virus (SIV) were developed that use HIV-1 Env for entry into target cells during the first replication cycle, but then switch to SIV Env usage. Antibodies binding to Env of HIV-1, but not SIV, block HIV-1 Env-mediated infection events after rectal exposure of non-human primates to the switching challenge vi...
Source: IAVI Rep - October 7, 2023 Category: Infectious Diseases Authors: Viktoria Stab Christiane Stahl-Hennig Armin Ensser Elie Richel Kirsten Fraedrich Ulrike Sauermann Bettina Tippler Florian Klein Dennis R Burton Matthias Tenbusch Klaus Überla Source Type: research
HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells
Cell Rep Med. 2023 Oct 17;4(10):101201. doi: 10.1016/j.xcrm.2023.101201. Epub 2023 Oct 6.ABSTRACTNeutralizing antibodies targeting HIV-1 Env have been shown to protect from systemic infection. To explore whether these antibodies can inhibit infection of the first cells, challenge viruses based on simian immunodeficiency virus (SIV) were developed that use HIV-1 Env for entry into target cells during the first replication cycle, but then switch to SIV Env usage. Antibodies binding to Env of HIV-1, but not SIV, block HIV-1 Env-mediated infection events after rectal exposure of non-human primates to the switching challenge vi...
Source: IAVI Rep - October 7, 2023 Category: Infectious Diseases Authors: Viktoria Stab Christiane Stahl-Hennig Armin Ensser Elie Richel Kirsten Fraedrich Ulrike Sauermann Bettina Tippler Florian Klein Dennis R Burton Matthias Tenbusch Klaus Überla Source Type: research
HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells
Cell Rep Med. 2023 Oct 17;4(10):101201. doi: 10.1016/j.xcrm.2023.101201. Epub 2023 Oct 6.ABSTRACTNeutralizing antibodies targeting HIV-1 Env have been shown to protect from systemic infection. To explore whether these antibodies can inhibit infection of the first cells, challenge viruses based on simian immunodeficiency virus (SIV) were developed that use HIV-1 Env for entry into target cells during the first replication cycle, but then switch to SIV Env usage. Antibodies binding to Env of HIV-1, but not SIV, block HIV-1 Env-mediated infection events after rectal exposure of non-human primates to the switching challenge vi...
Source: IAVI Rep - October 7, 2023 Category: Infectious Diseases Authors: Viktoria Stab Christiane Stahl-Hennig Armin Ensser Elie Richel Kirsten Fraedrich Ulrike Sauermann Bettina Tippler Florian Klein Dennis R Burton Matthias Tenbusch Klaus Überla Source Type: research
HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells
Cell Rep Med. 2023 Oct 17;4(10):101201. doi: 10.1016/j.xcrm.2023.101201. Epub 2023 Oct 6.ABSTRACTNeutralizing antibodies targeting HIV-1 Env have been shown to protect from systemic infection. To explore whether these antibodies can inhibit infection of the first cells, challenge viruses based on simian immunodeficiency virus (SIV) were developed that use HIV-1 Env for entry into target cells during the first replication cycle, but then switch to SIV Env usage. Antibodies binding to Env of HIV-1, but not SIV, block HIV-1 Env-mediated infection events after rectal exposure of non-human primates to the switching challenge vi...
Source: IAVI Rep - October 7, 2023 Category: Infectious Diseases Authors: Viktoria Stab Christiane Stahl-Hennig Armin Ensser Elie Richel Kirsten Fraedrich Ulrike Sauermann Bettina Tippler Florian Klein Dennis R Burton Matthias Tenbusch Klaus Überla Source Type: research
HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells
Cell Rep Med. 2023 Oct 17;4(10):101201. doi: 10.1016/j.xcrm.2023.101201. Epub 2023 Oct 6.ABSTRACTNeutralizing antibodies targeting HIV-1 Env have been shown to protect from systemic infection. To explore whether these antibodies can inhibit infection of the first cells, challenge viruses based on simian immunodeficiency virus (SIV) were developed that use HIV-1 Env for entry into target cells during the first replication cycle, but then switch to SIV Env usage. Antibodies binding to Env of HIV-1, but not SIV, block HIV-1 Env-mediated infection events after rectal exposure of non-human primates to the switching challenge vi...
Source: IAVI Rep - October 7, 2023 Category: Infectious Diseases Authors: Viktoria Stab Christiane Stahl-Hennig Armin Ensser Elie Richel Kirsten Fraedrich Ulrike Sauermann Bettina Tippler Florian Klein Dennis R Burton Matthias Tenbusch Klaus Überla Source Type: research
HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells
Cell Rep Med. 2023 Oct 17;4(10):101201. doi: 10.1016/j.xcrm.2023.101201. Epub 2023 Oct 6.ABSTRACTNeutralizing antibodies targeting HIV-1 Env have been shown to protect from systemic infection. To explore whether these antibodies can inhibit infection of the first cells, challenge viruses based on simian immunodeficiency virus (SIV) were developed that use HIV-1 Env for entry into target cells during the first replication cycle, but then switch to SIV Env usage. Antibodies binding to Env of HIV-1, but not SIV, block HIV-1 Env-mediated infection events after rectal exposure of non-human primates to the switching challenge vi...
Source: IAVI Rep - October 7, 2023 Category: Infectious Diseases Authors: Viktoria Stab Christiane Stahl-Hennig Armin Ensser Elie Richel Kirsten Fraedrich Ulrike Sauermann Bettina Tippler Florian Klein Dennis R Burton Matthias Tenbusch Klaus Überla Source Type: research
HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells
Cell Rep Med. 2023 Oct 17;4(10):101201. doi: 10.1016/j.xcrm.2023.101201. Epub 2023 Oct 6.ABSTRACTNeutralizing antibodies targeting HIV-1 Env have been shown to protect from systemic infection. To explore whether these antibodies can inhibit infection of the first cells, challenge viruses based on simian immunodeficiency virus (SIV) were developed that use HIV-1 Env for entry into target cells during the first replication cycle, but then switch to SIV Env usage. Antibodies binding to Env of HIV-1, but not SIV, block HIV-1 Env-mediated infection events after rectal exposure of non-human primates to the switching challenge vi...
Source: IAVI Rep - October 7, 2023 Category: Infectious Diseases Authors: Viktoria Stab Christiane Stahl-Hennig Armin Ensser Elie Richel Kirsten Fraedrich Ulrike Sauermann Bettina Tippler Florian Klein Dennis R Burton Matthias Tenbusch Klaus Überla Source Type: research
HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells
Cell Rep Med. 2023 Oct 17;4(10):101201. doi: 10.1016/j.xcrm.2023.101201. Epub 2023 Oct 6.ABSTRACTNeutralizing antibodies targeting HIV-1 Env have been shown to protect from systemic infection. To explore whether these antibodies can inhibit infection of the first cells, challenge viruses based on simian immunodeficiency virus (SIV) were developed that use HIV-1 Env for entry into target cells during the first replication cycle, but then switch to SIV Env usage. Antibodies binding to Env of HIV-1, but not SIV, block HIV-1 Env-mediated infection events after rectal exposure of non-human primates to the switching challenge vi...
Source: IAVI Rep - October 7, 2023 Category: Infectious Diseases Authors: Viktoria Stab Christiane Stahl-Hennig Armin Ensser Elie Richel Kirsten Fraedrich Ulrike Sauermann Bettina Tippler Florian Klein Dennis R Burton Matthias Tenbusch Klaus Überla Source Type: research
HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells
Cell Rep Med. 2023 Oct 17;4(10):101201. doi: 10.1016/j.xcrm.2023.101201. Epub 2023 Oct 6.ABSTRACTNeutralizing antibodies targeting HIV-1 Env have been shown to protect from systemic infection. To explore whether these antibodies can inhibit infection of the first cells, challenge viruses based on simian immunodeficiency virus (SIV) were developed that use HIV-1 Env for entry into target cells during the first replication cycle, but then switch to SIV Env usage. Antibodies binding to Env of HIV-1, but not SIV, block HIV-1 Env-mediated infection events after rectal exposure of non-human primates to the switching challenge vi...
Source: IAVI Rep - October 7, 2023 Category: Infectious Diseases Authors: Viktoria Stab Christiane Stahl-Hennig Armin Ensser Elie Richel Kirsten Fraedrich Ulrike Sauermann Bettina Tippler Florian Klein Dennis R Burton Matthias Tenbusch Klaus Überla Source Type: research
HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells
Cell Rep Med. 2023 Oct 17;4(10):101201. doi: 10.1016/j.xcrm.2023.101201. Epub 2023 Oct 6.ABSTRACTNeutralizing antibodies targeting HIV-1 Env have been shown to protect from systemic infection. To explore whether these antibodies can inhibit infection of the first cells, challenge viruses based on simian immunodeficiency virus (SIV) were developed that use HIV-1 Env for entry into target cells during the first replication cycle, but then switch to SIV Env usage. Antibodies binding to Env of HIV-1, but not SIV, block HIV-1 Env-mediated infection events after rectal exposure of non-human primates to the switching challenge vi...
Source: IAVI Rep - October 7, 2023 Category: Infectious Diseases Authors: Viktoria Stab Christiane Stahl-Hennig Armin Ensser Elie Richel Kirsten Fraedrich Ulrike Sauermann Bettina Tippler Florian Klein Dennis R Burton Matthias Tenbusch Klaus Überla Source Type: research
HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells
Cell Rep Med. 2023 Oct 17;4(10):101201. doi: 10.1016/j.xcrm.2023.101201. Epub 2023 Oct 6.ABSTRACTNeutralizing antibodies targeting HIV-1 Env have been shown to protect from systemic infection. To explore whether these antibodies can inhibit infection of the first cells, challenge viruses based on simian immunodeficiency virus (SIV) were developed that use HIV-1 Env for entry into target cells during the first replication cycle, but then switch to SIV Env usage. Antibodies binding to Env of HIV-1, but not SIV, block HIV-1 Env-mediated infection events after rectal exposure of non-human primates to the switching challenge vi...
Source: IAVI Rep - October 7, 2023 Category: Infectious Diseases Authors: Viktoria Stab Christiane Stahl-Hennig Armin Ensser Elie Richel Kirsten Fraedrich Ulrike Sauermann Bettina Tippler Florian Klein Dennis R Burton Matthias Tenbusch Klaus Überla Source Type: research
HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells
Cell Rep Med. 2023 Oct 17;4(10):101201. doi: 10.1016/j.xcrm.2023.101201. Epub 2023 Oct 6.ABSTRACTNeutralizing antibodies targeting HIV-1 Env have been shown to protect from systemic infection. To explore whether these antibodies can inhibit infection of the first cells, challenge viruses based on simian immunodeficiency virus (SIV) were developed that use HIV-1 Env for entry into target cells during the first replication cycle, but then switch to SIV Env usage. Antibodies binding to Env of HIV-1, but not SIV, block HIV-1 Env-mediated infection events after rectal exposure of non-human primates to the switching challenge vi...
Source: IAVI Rep - October 7, 2023 Category: Infectious Diseases Authors: Viktoria Stab Christiane Stahl-Hennig Armin Ensser Elie Richel Kirsten Fraedrich Ulrike Sauermann Bettina Tippler Florian Klein Dennis R Burton Matthias Tenbusch Klaus Überla Source Type: research
HIV-1 neutralizing antibodies provide sterilizing immunity by blocking infection of the first cells
Cell Rep Med. 2023 Oct 17;4(10):101201. doi: 10.1016/j.xcrm.2023.101201. Epub 2023 Oct 6.ABSTRACTNeutralizing antibodies targeting HIV-1 Env have been shown to protect from systemic infection. To explore whether these antibodies can inhibit infection of the first cells, challenge viruses based on simian immunodeficiency virus (SIV) were developed that use HIV-1 Env for entry into target cells during the first replication cycle, but then switch to SIV Env usage. Antibodies binding to Env of HIV-1, but not SIV, block HIV-1 Env-mediated infection events after rectal exposure of non-human primates to the switching challenge vi...
Source: IAVI Rep - October 7, 2023 Category: Infectious Diseases Authors: Viktoria Stab Christiane Stahl-Hennig Armin Ensser Elie Richel Kirsten Fraedrich Ulrike Sauermann Bettina Tippler Florian Klein Dennis R Burton Matthias Tenbusch Klaus Überla Source Type: research
