Hormonal contraceptives for contraception in overweight or obese women.
CONCLUSIONS: The evidence generally did not indicate an association between higher BMI or weight and effectiveness of hormonal contraceptives. However, we found few studies for most contraceptive methods. Studies using BMI, rather than weight alone, can provide information about whether body composition is related to contraceptive effectiveness. The contraceptive methods examined here are among the most effective when used according to the recommended regimen.We considered the overall quality of evidence to be low for the objectives of this review. More recent reports provided evidence of varying quality, while the quality...
Source: Cochrane Database of Systematic Reviews - August 17, 2016 Category: Journals (General) Authors: Lopez LM, Bernholc A, Chen M, Grey TW, Otterness C, Westhoff C, Edelman A, Helmerhorst FM Tags: Cochrane Database Syst Rev Source Type: research
Hepatic Adenomas in Adolescents with Endometriosis Treated with Norethindrone Acetate
Endometriosis—the implantation of endometrial-like tissue outside of the uterus— affects approximately 10% of female adolescents and adults, who often experience pain and infertility. First-line medical treatment includes treatment with progesterone-only or combined oral contraceptive pills. Estrogen-containing contraceptives are associated with increased risk of hepatic adenomas (3-4 per 100,000), which can cause life-threatening hemorrhage1. Association of progesterone-only medications with hepatic adenomas has not been reported, though peripheral conversion of norethindrone acetate (NET-A) to ethinyl estradiol—at ...
Source: Journal of Pediatric and Adolescent Gynecology - February 19, 2016 Category: OBGYN Authors: P.C. Brady, S.A. Missmer, M.R. Laufer Source Type: research
Hypertriglyceridemic Pancreatitis Caused by the Oral Contraceptive Agent Estrostep
We report a case of severe hypertriglyceridemia-induced acute pancreatitis in a 24-year-old woman caused by Estrostep, occurring nearly 10 years after she began using the drug. The patient was admitted to the medical intensive care unit (ICU) for aggressive volume resuscitation and management of severe electrolyte abnormalities. Laboratory studies obtained on admission indicated severe hypertriglyceridemia (2,200 mg/dL), hyponatremia (120 mEq/L), and hypocalcemia (0.78 mmol/L). Amylase and lipase levels were also elevated (193 and 200 U/L, respectively). Ranson score calculated after 48 hours of admission was 4, and her Ac...
Source: Journal of Intensive Care Medicine - June 4, 2015 Category: Intensive Care Authors: Abraham, M., Mitchell, J., Simsovits, D., Gasperino, J. Tags: Case Report Source Type: research
Norethindrone Acetate 1.0 Milligram and Ethinyl Estradiol 10 Micrograms as an Ultra Low-Dose Oral Contraceptive.
CONCLUSION:: The findings of this study demonstrate that this ultra low-dose OCP regimen is effective in preventing pregnancy with a safety and tolerability profile that is comparable with that reported for other low-dose OCPs.
CLINICAL TRIAL REGISTRATION:: ClinicalTrials.gov, www.clinicaltrials.gov, NCT00391807. LEVEL OF EVIDENCE:: III.
PMID: 23921878 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - August 5, 2013 Category: OBGYN Authors: Archer DF, Nakajima ST, Sawyer AT, Wentworth J, Trupin S, Koltun WD, Gilbert RD, Ellman H Tags: Obstet Gynecol Source Type: research
