Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for moderate-to-severe acne: Efficacy and safety results from two randomized phase 3 trials
A three-pronged acne treatment approach —combining an antibiotic, antibacterial agent, and retinoid—may provide greater efficacy than single/double treatments. Topical clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide (BPO) 3.1% gel (IDP-126) is the first fixed-dose triple-combination in development for acne. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - September 1, 2023 Category: Dermatology Authors: Linda Stein Gold, Edward Lain, James Q. Del Rosso, Michael Gold, Zoe D. Draelos, Lawrence F. Eichenfield, Neil Sadick, William P. Werschler, Melinda J. Gooderham, Mary Lupo Tags: Original article Source Type: research
Dermal sensitization, safety, and tolerability of triple-combination clindamycin phosphate 1.2%/benzoyl peroxide 3.1%/adapalene 0.15% gel from three clinical trials
CONCLUSIONS: The results from these three studies show that the triple-combination IDP-126 had a positive safety profile and was well tolerated in healthy participants and those with moderate-to-severe acne.PMID:37341243 | DOI:10.1080/09546634.2023.2220446 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 21, 2023 Category: Dermatology Authors: Zoe D Draelos Emil A Tanghetti Leon H Kircik Neal Bhatia Joshua A Zeichner Jeffrey L Sugarman Linda Stein Gold Source Type: research
Efficacy and tolerability of three topical acne treatments by body mass index: post hoc analysis including overweight and obese patients
CONCLUSIONS: CP/BPO 1.2%/3.75% gel, tretinoin 0.05% lotion, and tazarotene 0.045% lotion were all effective in reducing acne lesions by ≥45% in overweight/obese patients with moderate-to-severe acne, comparable to the underweight-to-normal group. Efficacy of these topical acne treatments is not greatly impacted by BMI and may be affected more by the formulation.PMID:35833564 | DOI:10.1080/09546634.2022.2071823 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - July 14, 2022 Category: Dermatology Authors: Jonette Keri Fran E Cook-Bolden Lawrence Green Leon H Kircik Hilary Baldwin William Philip Werschler Eric Guenin Radhakrishnan Pillai Varsha Bhatt Source Type: research
