Clindamycin phosphate 1.2%/benzoyl peroxide 3% fixed ‐dose combination gel versus topical combination therapy of adapalene 0.1% gel and clindamycin phosphate 1.2% gel in the treatment of acne vulgaris in Japanese patients: A multicenter, randomized, investigator‐blind, parallel‐group study
The Journal of Dermatology, EarlyView. (Source: The Journal of Dermatology)
Source: The Journal of Dermatology - June 15, 2018 Category: Dermatology Authors: Nobukazu Hayashi , Ichiro Kurokawa , Obukohwo Siakpere , Akira Endo , Toshiki Hatanaka , Masahiro Yamada , Makoto Kawashima Source Type: research

Management of Severe Acne Vulgaris With Topical Therapy.
Authors: Stein Gold L, Baldwin HE, Lin T Abstract Acne vulgaris (acne) is the most common skin disease we see in dermatology practice. Although rare in childhood, severe acne can affect up to 12% of the adolescent population. A chronic disease, it requires both aggressive management and effective maintenance strategies. Oral antibiotics, in combination with topical agents are recommended for treatment, with topical agents being continued as maintenance therapy to minimize resistance and recurrence. However, concerns with systemic side effects have recently resulted in a greater focus on the potential of fixed combi...
Source: Journal of Drugs in Dermatology - November 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Fixed Combination of Clindamycin Phosphate 1.2% and Benzoyl Peroxide 3.75% Aqueous Gel: Long-Term Use in Adult Females With Moderate Acne Vulgaris.
CONCLUSIONS: Clindamycin-BP 3.75% gel demonstrates continued improvement in symptoms of moderate acne over 24 weeks, with good tolerability, demonstrating a clinical benefit of continued clindamycin-BP 3.75% gel as a maintenance therapy for acne in adult female patients. J Drugs Dermatol. 2017;16(6):543-546.. PMID: 28686771 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - July 9, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Benzoyl peroxide and clindamycin topical skin preparation decreases Propionibacterium acnes deep colonization in shoulder arthroscopy
The objective of this study was to investigate whether a benzoyl peroxide and clindamycin preoperative surgical skin preparation reduces the incidence of P. (Source: Journal of Shoulder and Elbow Surgery)
Source: Journal of Shoulder and Elbow Surgery - April 11, 2017 Category: Orthopaedics Authors: Hailey Dizay, Diana Lau, Wesley M. Nottage Source Type: research

Efficacy, tolerability and impact on quality of life of clindamycin phosphate and benzoyl peroxide for the treatment of cetuximab-associated acneiform eruption in patients with metastatic colorectal cancer.
CONCLUSION: A clindamycin phosphate-benzoyl peroxide gel may be an effective and safe option in the treatment of cetuximab-associated acneiform eruptions. PMID: 26313697 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 16, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Profile of clindamycin phosphate 1.2%/benzoyl peroxide 3.75% aqueous gel for the treatment of acne vulgaris.
Authors: Nguyen TA, Eichenfield LF Abstract Acne vulgaris is a common and chronic skin disease, and is a frequent source of morbidity for affected patients. Treatment of acne vulgaris is often difficult due to the multifactorial nature of this disease. Combination therapy, such as that containing clindamycin and benzoyl peroxide, has become the standard of care. Several fixed formulations of clindamycin 1% and benzoyl peroxide of varying concentrations are available and have been used with considerable success. The major limitation is irritation and dryness from higher concentrations of benzoyl peroxide, and a comb...
Source: Clinical, Cosmetic and Investigational Dermatology - November 30, 2015 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Efficacy and Tolerability of a Fixed Combination of Clindamycin Phosphate (1.2%) and Benzoyl Peroxide (3.75%) Aqueous Gel in Moderate and Severe Acne Vulgaris Subpopulations.
CONCLUSIONS: Clindamycin-BP 3.75% aqueous gel is an effective and well-tolerated once-daily topical treatment for both moderate and severe acne J Drugs Dermatol. 2015;14(9):969-974. PMID: 26355615 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - September 12, 2015 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Efficacy of clindamycin phosphate and benzoyl peroxide gel (DUAC®) in the treatment of EGFR inhibitors‐associated acneiform eruption
(Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - August 20, 2015 Category: Dermatology Authors: M. Vaccaro, F. Guarneri, F. Borgia, A. Pollicino, G. Altavilla, S. P. Cannavò Tags: Letter to the Editor Source Type: research

Efficacy of clindamycin phosphate and benzoyl peroxide gel (DUAC ®) in the treatment of EGFR inhibitors‐associated acneiform eruption
(Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - August 19, 2015 Category: Dermatology Authors: M. Vaccaro, F. Guarneri, F. Borgia, A. Pollicino, G. Altavilla, S. P. Cannav ò Tags: Letter to the Editor Source Type: research

The Efficacy and Tolerability of a Fixed Combination Clindamycin (1.2%) and Benzoyl Peroxide (3.75%) Aqueous Gel in Patients With Facial Acne Vulgaris: Gender as a Clinically Relevant Outcome Variable.
CONCLUSIONS: Clindamycin phosphate 1.2%/BP 3.75% gel provides statistically significant greater efficacy than vehicle with a favorable safety and tolerability profile. It appears to be more effective in female patients. J Drugs Dermatol. 2015;14(4):381-384. PMID: 25844612 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - April 7, 2015 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Clindamycin phosphate 1·2%–benzoyl peroxide 3·0% fixed‐dose combination gel has an effective and acceptable safety and tolerability profile for the treatment of acne vulgaris in Japanese patients: a phase 3, multicentre, randomized, single‐blinded, active‐controlled, parallel group study
Summary BackgroundA topical fixed‐dose clindamycin phosphate 1·2% and benzoyl peroxide 3·0% combination gel (CLNP/BPO 3%) is known to be effective and safe in white people with acne. ObjectivesTo evaluate the efficacy and safety of CLNP/BPO 3·0% topically applied once or twice daily vs. CLNP twice daily in Japanese patients with acne. MethodsEight hundred patients were randomized to receive CLNP/BPO 3·0% once daily, CLNP/BPO 3·0% twice daily or CLNP twice daily for 12 weeks. Primary endpoints were absolute change in number of total lesions (TLs) from baseline to week 12 to demonstr...
Source: British Journal of Dermatology - January 7, 2015 Category: Dermatology Authors: M. Kawashima, H. Hashimoto, A.B. Alió Sáenz, M. Ono, M. Yamada Tags: Therapeutics Source Type: research

An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 3.75% for the once-daily treatment of moderate to severe acne vulgaris.
CONCLUSIONS: Clindamycin-BP 3.75% provides statistically significant greater efficacy than vehicle with a favorable safety and tolerability profile. PMID: 25226009 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 2, 2014 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Clindamycin phosphate 1.2%–benzoyl peroxide 3% fixed‐dose combination gel has an effective and acceptable safety and tolerability profile for the treatment of acne vulgaris in Japanese patients: a phase III, multicentre, randomised, single‐blinded, active‐controlled, parallel‐group study
Summary BackgroundA topical fixed‐dose clindamycin phosphate 1.2% and benzoyl peroxide 3% combination gel (CLNP/BPO 3%) is known to be effective and safe in Caucasians with acne. ObjectivesTo evaluate the efficacy and safety of CLNP/BPO 3% topically applied once (‐QD) or twice (‐BID) daily versus CLNP‐BID in Japanese acne patients. MethodsEight hundred patients were randomised to receive CLNP/BPO 3%‐QD, CLNP/BPO 3%‐BID or CLNP‐BID for 12 weeks. Primary endpoints were absolute change in number of total lesions (TLs) from baseline to Week 12 to demonstrate the superiority of CLNP/BPO 3%‐BID and non‐inferior...
Source: British Journal of Dermatology - July 12, 2014 Category: Dermatology Authors: M. Kawashima, H. Hashimoto, A.B. Alió Sáenz, M. Ono, M. Yamada Tags: Therapeutics Source Type: research

Clindamycin phosphate 1.2%-benzoyl peroxide 3% fixed-dose combination gel has an effective and acceptable safety and tolerability profile for the treatment of acne vulgaris in Japanese patients: a phase III, multicentre, randomised, single-blinded, active-controlled, parallel-group study.
M, Yamada M Abstract BACKGROUND: A topical fixed-dose clindamycin phosphate 1.2% and benzoyl peroxide 3% combination gel (CLNP/BPO 3%) is known to be effective and safe in Caucasians with acne. OBJECTIVES: To evaluate the efficacy and safety of CLNP/BPO 3% topically applied once (-QD) or twice (-BID) daily versus CLNP-BID in Japanese acne patients. METHODS: Eight hundred patients were randomised to receive CLNP/BPO 3%-QD, CLNP/BPO 3%-BID or CLNP-BID for 12 weeks. Primary endpoints were absolute change in number of total lesions (TLs) from baseline to Week 12 to demonstrate the superiority of CLNP/BPO 3%-...
Source: The British Journal of Dermatology - July 12, 2014 Category: Dermatology Authors: Kawashima M, Hashimoto H, Alió Sáenz AB, Ono M, Yamada M Tags: Br J Dermatol Source Type: research