Synthetic vaccines targeting Mincle through conjugation of trehalose dibehenate

Chem Commun (Camb). 2022 May 31. doi: 10.1039/d2cc02100e. Online ahead of print.ABSTRACTThe covalent fusion of immunostimulatory adjuvants to immunogenic antigens is a promising strategy for the development of effective synthetic vaccines for infectious diseases. Herein, we describe the conjugation of a mycobacterial peptide antigen from the 6 kDa early secretory antigenic target (ESAT6) to a suitably functionalised trehalose dibehenate (TDB), a potent glycolipid adjuvant targeting macrophage inducible C-type lectin (Mincle).PMID:35638863 | DOI:10.1039/d2cc02100e

Source: Chemical Communications - May 31, 2022 Category: Chemistry Authors: Cameron C Hanna Joshua W C Maxwell Hendra S Ismanto Anneliese S Ashhurst Lukas M Artner Santosh Rudrawar Warwick J Britton Sho Yamasaki Richard J Payne Source Type: research