Whip- and pinworm infections elicit contrasting effector and distinct regulatory responses in wild house mice

Int J Parasitol. 2022 May 6:S0020-7519(22)00080-7. doi: 10.1016/j.ijpara.2022.03.006. Online ahead of print.ABSTRACTInfections with high doses of intestinal nematodes result in protective immunity based on robust type 2 responses in most mouse lines under laboratory conditions. Here, we report on cellular responses of wild house mice from northern Germany. We detected robust Th1 responses in wild house mice naturally infected with the whipworm Trichuris muris. In contrast, mice infected with pinworms (Syphacia, Aspiculuris) reported type-2 activity by elevated IgG1 levels and eosinophil counts, but also harbored high frequencies of Foxp3+ Treg cells, suggesting that natural whip- and pinworm infections induce distinct immunoregulatory as well as effector profiles.PMID:35533731 | DOI:10.1016/j.ijpara.2022.03.006

Source: International Journal for Parasitology - May 9, 2022 Category: Parasitology Authors: Hongwei Zhang Lubom ír Bednář Emanuel Heitlinger Susanne Hartmann Sebastian Rausch Source Type: research