Synergistic Associations of Depressive Symptoms and Executive Functions With Longitudinal Trajectories of Diabetes Biomarkers Among Urban-Dwelling Adults Without Diabetes

We examined the synergistic associations of depressive symptoms and EFs with longitudinal trajectories of diabetes diagnostic criteria among middle-aged and older adults without diabetes. Methods Participants were 1257 African American and White, urban-dwelling adults from the Healthy Aging in Neighborhoods of Diversity across the Life Span study who were assessed up to three times over a 13-year period (2004–2017). At baseline, participants completed the Center for Epidemiological Studies—Depression scale and measures of EFs—Trail Making Test Part B, verbal fluency, and Digit Span Backward—for a composite EFs score, and provided blood samples at each follow-up for glycated hemoglobin and fasting serum glucose. Results A total of 155 and 220 individuals developed diabetes or prediabetes at wave 3 and wave 4, respectively. Linear mixed-effects regression models adjusting for sociodemographic factors, diabetes risk factors, and antidepressant medications revealed significant three-way interactions of Center for Epidemiological Studies—Depression, EFs, and age on change in glycated hemoglobin (b = −0.0001, p = .005) and in fasting serum glucose (b = −0.0004, p
Source: Psychosomatic Medicine - Category: Psychiatry & Psychology Tags: ORIGINAL ARTICLES Source Type: research