Association between coronary artery calcium score and in-stent restenosis after drug-eluting stent implantation

Background Coronary artery calcium (CAC) is a modifiable contributor of in-stent restenosis (ISR), but quantitative analyses using a noninvasive approach are limited. We aimed to investigate the associations between CAC score derived from ECG-gated coronary computed tomography angiography (CCTA) or non-gated non-contrast chest computed tomography (NCCT) and ISR. Methods We included 368 lesions in 194 patients with coronary drug-eluting stent implantations in final analyses. CAC was quantified using the Agatston score. Primary endpoint was ISR, defined as lumen diameter stenosis over 50% at the stent segment or its proximal or distal edges (5-mm segments adjacent to the stent), at angiographic follow-up. Results The CAC scores in either CCTA/2.5 mm group (r = 0.7702; P 209 in NCCT/5 mm group independently associated with an 8.46- and 21.89-fold increase in ISR, respectively (all P 245 in CCTA/2.5 mm or>209 in NCCT/5 mm was significantly associated with increased risk in ISR.
Source: Coronary Artery Disease - Category: Cardiology Tags: Original Research in CAD Source Type: research