Biocatalytic asymmetric synthesis of secondary allylic alcohols using Burkholderia cepacia lipase immobilized on multiwalled carbon nanotubes

Chirality. 2022 May 4. doi: 10.1002/chir.23454. Online ahead of print.ABSTRACTThe lipase from Burkholderia cepacia (BCL) was immobilized through physical adsorption on pristine and functionalized multiwalled carbon nanotubes (MWCNTs) with carboxyl or amine groups and used in the stereoselective acylation of (R,S)-1-octen-3-ol (1) and (R,S)-(E)-4-phenyl-3-buten-2-ol (4) with vinyl acetate. All immobilized preparations produced better results than free BCL. For (R,S)-4, 50% conversion and E > 200 were obtained in n-hexane or in solvent-free medium. For (R,S)-1, in solvent-free medium, the conversion was 38% with a slight increase in the E-value (E = 10).PMID:35506895 | DOI:10.1002/chir.23454

Source: Chirality - May 4, 2022 Category: Molecular Biology Authors: Michele do Rocio Gon çalves Dias Gesieli Prado Cardoso da Silva Alysson de Pauloveloso Nadia Krieger Cristiane Piliss ão Source Type: research