Systematic review of the CUP trials characteristics and perspectives for next-generation studies

Cancer of unknown primary (CUP) includes a group of heterogeneous malignancies without a detectable anatomical primary tumor despite thorough diagnostic workup [1]. Furthermore, CUP can comprise multiple occult tissues of origin. The median age of CUP patients is 65 years [2,3] . Three decades ago, CUP constituted 3-5% of all malignancies, ranked seventh in frequency, and was the fourth-highest cause of cancer-related death. Currently, CUP comprises 1-2% of all malignancies, likely due to radiological and molecular diagnostic advancements [3].

Source: Cancer Treatment Reviews - May 6, 2022 Category: Cancer & Oncology Authors: Elie Rassy, Chris Labaki, Roy Chebel, Stergios Boussios, Julie Smith Gagen, F. Anthony Greco, Nicholas Pavlidis Source Type: research